189,641 research outputs found
Recenzja pracy grupowej_Krzeczkowska_F_Dabrowska,Krawczyk,Kuduk,Micherda_Mierzchała
No full text<p>This paper is a review of work Fri. "Financial management in the enterprise on the example of Polish institutions" by students of the University of Economics in Wroclaw - A. Dabrowska, K. Krawczyk, Y. Kuduk, A. Micherdy, A. Mierzchały.<br>Review aims to examine the adequacy made by the author of evaluating the financial management of Polish companies using the so-called. 10 steps to create the company in 2013 and assess the regularity formulated by them on the basis of applications.</p>
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How to use Rosen's normalised equilibrium to enforce a socially desirable Pareto efficient solution
No full textWe consider a situation, in which a regulator believes that constraining a complex good created jointly by competitive agents, is socially desirable. Individual levels of outputs that generate the constrained amount of the externality can be computed as a Pareto efficient solution of the agents' joint utility maximisation problem. However, generically, a Pareto efficient solution is not an equilibrium. We suggest the regulator calculates a Nash-Rosen coupled-constraint equilibrium (or a “generalised” Nash equilibrium) and uses the coupled-constraint Lagrange multiplier to formulate a threat, under which the agents will play a decoupled Nash game. An equilibrium of this game will possibly coincide with the Pareto efficient solution. We focus on situations when the constraints are saturated and examine, under which conditions a match between an equilibrium and a Pareto solution is possible. We illustrate our findings using a model for a coordination problem, in which firms' outputs depend on each other and where the output levels are important for the regulator.
Refleksje na temat pracy : ,,Analiza ekonomicznej kondycji na przykładzie przedsiębiorstwa zajmującego się przetwórstwem owoców” autorstwa K. Krawczyk
No full text<p>The aim of this paper is to review the work entitled. ,,Analysis of economic health – enterprise engaged in the processing of friut case ". The work was done by a student of the University of Economics in Wroclaw – Karolina Krawczyk.<br>The Relevant work was aimed to analyze the economic condition of one of the Polish food processing sector enterprises in 2010-2013. To assess its efficiency and financial level, the author calculated and interpreted John Zietlow’s PHI model which consists of 15 indicators divided according to time horizon. Additionally she calculated such indices as: the risk of liquidation, profitability ROA and ROE, growth in enterprise value and the residual value EVA.</p
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Yunnan (China), P-40 aircraft
No full textYunnan Province, China 1943 - 1945P-40 fighter, the famous 'Flying Tiger'. This photo was taken at Kunming, China. Kunming was the headquarters for the 14th Air Force. It shows a close-up of the air scoop and of course the 'shark mouth'. The reason the shark mouths were painted on the noses was because the Japanese had a deathly fear of sharks. This tactic was used to demoralize sailors as the P-40's would strafe some of the ships in the bays, harbors, and on the rivers. The P-40 was an adequate plane, but no real match against the Japanese Zero. The P-40's fought in pairs against the Zeros since they could not compete against the Zero on a one to one basis below 18,000 feet.GrayscaleBox
Dataset for "Reconfigurable spin-wave platform based on interplay between nanodots and waveguide in hybrid magnonic crystal"
No full text<p>The dataset consist of the data used to prepare the figures for the manuscript: </p>
<p>Krzysztof Szulc, Mateusz Zelent, Maciej Krawczyk<br><em>Reconfigurable spin-wave platform based on interplay between nanodots and waveguide in hybrid magnonic crystal.</em></p>
<p>Please read README.txt file to see the description of the data in the files</p><p>K.S. and M.K. acknowledge the financial support from National Science Centre, Poland, grants no. UMO-2020/39/I/ST3/02413 and UMO-2021/41/N/ST3/04478. K.S. acknowledges the financial support from the Foundation for Polish Science.</p>
krawczyk
No full textRecently the common adiponutrin (PNPLA3) polymorphism p.I148M has been identified as a genetic determinant of severe forms of non-alcoholic fatty liver disease and alcoholic liver disease. Additionally, insulin resistance -linked to the development of non-alcoholic steatohepatitis -increases the risk of developing gallstones. Here we assessed whether the PNPLA3 p.I148M (c.444 C>G) polymorphism affects glucose and lipid levels and increases gallstone risk. We analysed 229 individuals with gallstones from 108 families (age 24-80 years, BMI 17-55 kg/m 2 ) and 258 gallstone-free controls (age 20-70 years, BMI 14-43 kg/m 2 ). Fasting glucose, triglyceride and cholesterol serum levels were determined. The p.I148M polymorphism was genotyped using a PCR-based assay with 5'-nuclease and fluorescence detection. Case-control association tests and nonparametric linkage (NPL) analysis in sib-pairs were performed. Individuals carrying the [GG] genotype had significantly (P<0.0001) higher median fasting glucose levels as compared to [GC] and [CC] carriers. After adjustment for multiple testing, we detected a trend for an association between triglyceride levels and variant adiponutrin in gallstone patients (P=0.032), and gallstone cases carrying the genotype [CC] presented with significantly higher triglyceride levels than the corresponding controls (P<0.003). No significant effects on cholesterol metabolism were detected. Neither genotype distributions nor NPL scores provided evidence for association or linkage between the PNPLA3 variant and gallstones. In conclusion, homozygous carriers of the PNPLA3 risk allele display higher fasting glucose. Although this adiponutrin variant may affect triglyceride homeostasis, it does not increase the risk of cholelithiasis. K e y w o r d s : adiponutrin, insulin resistance, metabolic syndrome, PNPLA3, single nucleotide polymorphism, triglyceride 25) and hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus infection Taking into account the previously reported association between the adiponutrin variant and non-genetic risk factors for gallstones (e.g. hepatic fat accumulation, liver injury, distorted glucose metabolism), we now aimed to dissect the possible role of the PNPLA3 SNP in gallstone formation. In this respect we genotyped a cohort of sibs with gallstones and unrelated gallstone-free controls. To investigate the role of variant adiponutrin in other metabolic traits, we related PNPLA3 genotypes to serum lipid and glucose levels. MATERIAL AND METHODS Patients Only individuals with documented Caucasian ethnicity were included in the study. As shown in In all study participants glucose, TG and cholesterol levels in serum (mg/dL) were determined by standard assays after an overnight fasting period. The study was conducted according to a study design approved by the local ethical committee, and all participants signed an informed consent form. Genotyping Genomic DNA was isolated from EDTA anticoagulated blood according to the membrane-based QIAamp DNA extraction protocol (Qiagen, Hilden, Germany). The PNPLA3 coding SNP p.I148M (rs738409) was genotyped using solutionphase hybridization reactions with 5'-nuclease and fluorescence detection (TaqMan assays) in a 7300 real-time PCR system (Applera, Norwalk, CT). Primer and probe sequences were: forward primer 5'-AACTTCTCTCTCCTTTGCTTTCACA-3'; reverse primer 5'-TCTACAGTGGCCTTATCCCTCC-3'; VIC 5'-TTCCTGCTTCATGCC-3'; FAM 5'-CCTGCTTCATCCC-3'. To ensure genotyping quality, we included negative controls and DNA samples with known PNPLA3 genotypes as internal controls. PCR reactions contained 20 ng DNA, 900 nM of each primer, 1× TaqMan Universal Master Mix, and 200 nM of VIClabelled and FAM-labelled probes in 25 µL-reactions. Amplification conditions were 95°C for 10 min, 40 cycles of 92°C for 15 s, and 60°C for 1 min. Statistics Unless stated otherwise, statistical analysis was performed with SPSS 18.0 (SPSS, Munich, Germany). All phenotypic quantitative data were expressed as medians and ranges, unless stated specifically. Because we performed multiple tests (n=17), the significance threshold was corrected for multiple testing and two-sided P values <0.003 were considered as significant. The effects of the adiponutrin SNP and of other potential lithogenic factors (age, BMI, gender, serum glucose and lipid levels) Exact tests were performed to check the consistency of genotyping results with Hardy-Weinberg equilibrium (HWE) (http://ihg2.helmholtz-muenchen.de/cgi-bin/hw/hwa1.pl). We performed power calculations using PS: Power and Sample Size Calculation v.3.0 (http://biostat. mc.vanderbilt.edu/wiki/ Main/PowerSampleSize) (35). Association case-control analysis and non-parametric linkage (NPL) tests were performed to investigate the role of the PNPLA3 p.I148M variant in the development of gallstones. For the association analysis, all gallstone-free controls and a single randomly selected member (these individuals are denoted cases throughout this report) of each sib-pair family were included. The association between the adiponutrin variant and cholelithiasis was tested in contingency tables (genotypes: Armitrage's trend test; alleles: chi 2 test). NPL scores were calculated using GENEHUNTER-MODSCORE v2.0.1 (www.staff.uni-marburg.de/_strauch/software.html) (36) both for the risk (minor) allele frequencies (MAF) in our ASP cohort and for alleles frequencies provided in the Entrez SNP database (http://www.ncbi.nlm.nih.gov/snp). In short, the NPL score allows estimation of the significance of a given allele shared among the family members in the development of the disease; for this the allele frequencies at the analysed genetic locus are compared with the null hypothesis of no linkage (4). Thus, if gallstone disease is linked to the PNPLA3 polymorphism, affected sibs are more likely to share the same allele. RESULTS Obesity enhances gallstone risk PNPLA3 p.I148M variant and gallstone risk: case-control association and sib-pairs analyses The adiponutrin p.I148M variant was successfully genotyped in all individuals with gallstones (n=229, Association between variant adiponutrin and metabolic traits For this analysis we included only unrelated cases (n=108) and all controls (n=258). DISCUSSION This study demonstrates that the adiponutrin p.I148M variant influences glucose and triglyceride levels in our study population. On the other hand, although it has been previously shown that fatty liver disease and enhanced liver fibrosis are both risk factors for cholelithiasis, the variant does not increase gallstone risk per se. Since our case-control study investigating the effect of the adiponutrin variant on gallstone formation is underpowered, we also performed a non-parametric linkage analysis. Indeed, the study cohort let us previously identify the ABCG8 p.D19H variant as the first genetic risk factor for gallstone formation in humans (4). In this study the analysis of sib-pairs showed that this variant was strongly associated with cholelithiasis (NPL score =7.1, P=4.6 x 10 -13 ), which was in line with results of a large GWAS in gallstone patients (3). Hence, the cohort of sib-pairs can be regarded as robust framework for identifying genes associated with gallstone formation. Additionally, sib-pair analysis omits the bias that is encountered in case-control analysis as controls could develop gallbladder stones later in life. Hence, the present analysis of sib-pairs, which did not reveal an association between gallstones and the PNPLA3 variant p.I148M, excludes this SNP as a major risk factor for cholelithiasis. BMI and serum glucose levels are known risk factors for gallstone formation (11). Our results show that each of these factors increases the disease risk, which is in line with the notion that cholelithiasis is a complex multifactorial disorder. Interestingly, we observed that increased serum cholesterol levels lowered the chance of developing gallstones. In contrast, previous studies have demonstrated that patients carrying the ABCG8 (35) and SLC10A2 (7) cholelithiasis risk variants present with lower total serum cholesterol concentrations. It can be hypothesised that the lower risk of developing gallstones in patients with increased serum cholesterol levels might be primarily due to decreased transport of cholesterol into bile. This might lead to increased serum cholesterol but lower biliary cholesterol concentrations. On the other hand, the use of cholesterol lowering drugs (e.g. statins) may significantly lower the risk of developing gallstones (37-39). Hence a functional link between cholesterol levels, hepatobiliary transporters and gallstone formation has not yet been thoroughly investigated and future studies are warranted. It has been previously shown that the PNPLA3 risk allele is associated with severe forms of hepatic fat accumulation In summary, our current study underscores the possible metabolic role of the adiponutrin p.I148M polymorphism. Nevertheless, given the negative results from the previous large studies this effect might be apparent only in selected individuals, for example in those who have gallstones as an additional phenotype. Although the variant does not increase the risk of developing gallstones per se, additional functional studies are warranted to define the molecular link between adiponutrin and metabolic traits
Frezarka do modeli plastycznych opis patentowy nr 108222 /
No full textZgłoszono 23 grudnia 1976 r.Zgłoszenie ogłoszono 3 lipca 1978 r.Opublikowano 15 stycznia 1981 r.Nr zgłosz. P 194728.Tyt. z ekranu tyt.Pozostali współtwórcy wynalazku: Edward Cholewa, Eugeniusz Krawczyk, Stanisław Twardosz.Dostępny także w wersji drukowanej.Tryb dostępu: Internet
Automatyczny układ śledzący do wykreślania krzywej natężenia oświetlenia opis patentowy nr 49084 /
No full textTyt. z ekranu tyt.Zgłoszono 23 listopada 1963 r.Numer zgłosz. P.103374.Opublikowano 5 lutego 1965 r.Pozostali współtwórcy wynalazku: Tadeusz Kochmański, Eugeniusz Krawczyk, Jerzy Ogorzałek.Dostępny także w wersji drukowanej.Tryb dostępu: Internet
Urządzenie do pokrywania płyt szklanych cienkimi warstwami metali oraz ich związkami opis patentowy patentu tymczasowego nr 86062 /
No full textTyt. z ekranu tyt.Zgłoszono 19 lipca 1974 r.Numer zgłosz. P.172894.Zgłoszenie ogłoszono 2 maja 1975 r.Opublikowano 30 lipca 1976 r.Pozostali twórcy wynalazku: Eugeniusz Krawczyk, Edward Leja, Jerzy Ogorzałek.Dostępny także w wersji drukowanej.Tryb dostępu: Internet
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