5,608 research outputs found
Two transcription activation functions in the amino terminus of the mouse estrogen receptor that are affected by the carboxy terminus
No full textTo determine the characteristics of the N-terminal transactivation domain (AF-1) of the mouse estrogen receptor (ER), we constructed a number of deletion mutants. Wild-type and mutant receptors were expressed in yeast cells and assayed for their ability to transactivate an estrogen-responsive reporter plasmid (ERE-CYCl-LacZ) that contained a single estrogen response element of the vitellogenin A2 gene promoter. Deletion of the N-terminal 121 animo acids from the mouse ER resulted in a 50% reduction in transaction activity compared with the full-length wild-type ER. Deletion of the first 150 amino acids resulted in loss of 90% transactivation activity. An ER deletion mutant lacking residues 121-154 retained full transcriptional activity, suggesting that this region plays a significant transacting role only when the first portion is deleted. A point mutation was introduced in the C-terminal region at Met-521 in order to study the possible interaction between the C-terminal ligand-binding domain and the N-terminal AF-1 region. This mutant ER, M521G, exhibited 150% of the transcriptional activity of the wild-type ER. An M521G mutant lacking the N-terminal 121 amino acids retained full transactivation activity, whereas, M521G lacking 150 amino acids resulted in only 10% of wild-type activity. These results suggest that residues 121-154 might interact with the C terminus to affect transcription. In summary, multiple N-terminal regions in the ER were identified that function in transactivation. Furthermore, a point mutation in the C-terminal portion of the ER may change the conformation of the ER ligand-binding domain, producing a more stable receptor/ligand complex that increases transcriptional activity. These data suggest that the N- and C-terminal portions of the ER interact in a cooperative manner to activate transcription from target genes. Published by Elsevier Science Inc
Interview with Kenneth Sprunt
No full textKenneth Sprunt was born in Wilmington in 1920, the third son of James Lawrence Sprunt. The Sprunts have a long history in and around Wilimington. His grandfather was a cotton merchant in the area and his great-great Uncle is the man for whom James Sprunt Community College is named for as well as the author of Chronicles of the Lower Cape Fear. Mr. Kenneth Sprunt relates his family history both before his birth and after. He spent three years in the Coast Guard during WWII primarily working on anti-submarine warfare in small boats
Memorandum from Kenneth Iyeko
No full textMemorandum from Kenneth Iyeko regarding establishment and support of the Japanese American Citizens' League at incarceration camps operated by War Relocation Authority.Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R. Goodman documenting the forced removal and incarceration of Japanese Americans during World War II, as well as organized resistance to incarceration. Included in the collection are records of the Japanese Young Men's Christian Association and the Japanese American Citizens' League in San Francisco, including papers of the Japanese YMCA's executive secretary Lincoln Kanai; Sakai family papers; Goodman's correspondence to and from Japanese American incarcerees, organizations opposing forced removal and incarceration of Japanese Americans, the War Relocation Authority, and others; publications, photographs, and ephemera from the Topaz Relocation Center, where Goodman taught high school; War Relocation Authority records and publications; and newspaper clippings, pamphlets, and reports about forced removal and incarceration created by various government, religious, and civic organizations, in California and nationwide
A Review by Kenneth Atkinson of Alexandria and Qumran: Back to the Beginning, by Kenneth Silver
No full textKenneth Silver (a.k.a. Kenneth A. K. Lönnqvist), is a historian and professional archaeologist, who has lived and worked for decades in the Near East. With extensive publications on Hellenistic and Roman archaeology, history, and numismatics, Silver is the director of a survey and mapping project in Northern Mesopotamia studying the border zone between the late Roman/ Byzantine Empires and Persia. Author of numerous publications on Qumran and related topics, Silver’s lengthy monograph proposes that the documents and type of library found at Qumran were based on models derived from Egypt. The main thesis of the volume is that Pythagorean philosophy is the core and basis for the beliefs reflected in the non-Biblical texts found at Qumran
Patterning of chorion proteins in the drosophila eggshell
No full textM.S.Includes bibliographical referencesby Kenneth Ki
The implications for ministry of the teachings of Kenneth Cracknell with special reference to former students
No full textTo be effective in ministry in the contemporary religious milieu, today's seminarians, tomorrow's church leaders, must receive more than a mere academic experience; they need practical experience as to how to function effectively within a socially diverse climate of faith. The author documents the long term impact of Kenneth Cracknell's attempts to nurture cross cultural understanding and cooperation within the seminary context. The intent of this exposition is to demonstrate that Kenneth Cracknell has purposefully created a tranformative environment using interfaith dialogue as an effective paradigm for informing today's diverse seminary population. To that end, opinions, reactions and musings of a dozen former students are documented and presented herein as models of appropriate conversation for interfaith dialogue
Cwbr Author Interview: Reluctant Rebels: The Confederates Who Joined The Army After 1861
No full textInterview with Dr. Kenneth W. Noe, Professor of History at Auburn University Interviewed by Nathan Buman Civil War Book Review (CWBR): I\u27m here today with Kenneth Noe, author of Reluctant Rebels: The Confederates Who Joined the Army after 1861. Professor Noe, thank you for joining me. Kenneth Noe (KN): I\u27m happy to be here Nathan
R. Kenneth Coleman and family.
No full textclient file of R. Kenneth Coleman; Corresponding Negative, folder 45https://egrove.olemiss.edu/miles/1173/thumbnail.jp
Food fraud and the Partnership for a ‘Healthier’ America: a case study in state-corporate crime
No full textAt a moment of heightened public concern over food-related health issues, major corporations in the food industry have found their products and practices under scrutiny. Needing to be understood as socially responsible, these corporations have established partnerships with the state to construct a positive, proactive, and cooperative public image. One major public-private partnership that evolved from former First Lady Michelle Obama’s Let’s Move initiative—the Partnership for a Healthier America (PHA)—serves as a case study in this paper, which analyzes the opportunity costs and social harms perpetuated by a public health campaign bound by the imperative to maximize profit. By using trusted state actors to deliver accurate but deceptive claims about food companies’ commitment to public health, this public-private partnership actively misleads the public and potentially exacerbates public health challenges, warranting a skeptical revision of how we understand corporate social responsibility and neoliberal governance on issues of health and nutrition. As a form of fraud, these attempts to mislead the public go beyond the actions of public sector individuals or members of corporate boards, but are structurally incentivized by the legal rights, regulatory privileges, and profit-related incentives central to the modern corporate form. While conventional criminological research tends to underemphasize state and corporate harms, we make use of a critical criminological perspective to analyze state-corporate partnerships in the space between food industry practices and public health policy.Peer reviewe
Marijuana legalization: comparing recent ballot initiatives
No full textMedical marijuana is now available in 23 states, and its growing acceptance has paved the way for the legalization of recreational marijuana. This article examines four recent campaigns to legalize recreational marijuana–two failures and two successes. Using data from newspaper sources, interviews with key players, and some other sources, we examine the factors that influence whether a ballot initiative succeeds or fails. We identify similarities and differences between the four measures, the social forces shaping the debate, their claims and counterclaims, and a set of factors that appear to increase the odds that a recreational marijuana ballot measure will be successful.Peer reviewe
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