216 research outputs found
From Barrett's Esophagus towards Adenocarcinoma: Genetic and Clinical studies
No full textEsophageal adenocarcinoma is a highly aggressive disease from which more than 80% of
patients die within 5 years after diagnosis. Worldwide almost 400,000 new patients are diagnosed
annually. Herewith esophageal cancer ranks eighth on the list of most common
cancers, and sixth on the list of cancer mortality causes 1. More than 90% of esophageal
cancers are either squamous cell carcinomas or adenocarcinomas 2. Esophageal cancer incidence
has been rapidly increasing in Western Europe and the USA 3-5. This could be mainly
ascribed to an increase in the rate of esophageal adenocarcinoma, which by now equals or
even exceeds the rate of esophageal squamous cell carcinomas. Esophageal cancer incidence
in the Netherlands is 10.2/100,000 for men and 3.2/100,000 for women with around
900 newly diagnosed patients annually 6. Adenocarcinomas of the gastric cardia and of the
esophagus, commonly located in the distal esophagus, have several similarities. They show a
parallel increase in incidence. Moreover, they show similarities in epidemiological and histomorphological
features as well as in patterns of comorbidity 7-9. This thesis mainly deals with
molecular biological aspects of adenocarcinomas of the distal esophagus and its precursor
lesion, Barrett’s esophagus, but also includes work on adenocarcinomas of the gastric cardia.
Adenocarcinomas from the distal third of the esophagus plus adenocarcinomas of the gastric
cardia are in this thesis altogether mentioned by the description “gastro-esophageal junction
(GEJ) adenocarcinomas”
Towards de-escalation of axillary management after neoadjuvant chemotherapy in breast cancer
No full textPatient-Reported Outcome Measures in Clinical Care: Methodological Aspects and Practical Applications
No full textRegarding “3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors reduce the risk of perioperative stroke and mortality after carotid endarterectomy”
No full text'Reply to: Moving forward with value-based healthcare: The need for a scientific approach'
No full textThe State of Patient-Centered Breast Cancer Care: An Academic Center’s Experience and Perspective
No full textOncological safety of prohylactic breast surgery; skin-sparing and nipple-sparing versus total mastectomy
No full text
- …
