3 research outputs found
Pharmacognostic evaluation of Vasa Ghrita
No full text550-559Justicia adhtoda L. is a well-known plant in India traditionally used for treatment of cough and cold. Vasa ghrita
formulation is prescribed in treatment of bronchial asthma. The main aim was to develop standardization protocol for the
Vasa ghrita formulation and to establish the standard limits range by considering another two marketed formulations (RVG
and KKVG). Preliminary morphological screening was performed to describe the leaf and the formulations, in which a
range was observed especially in terms of their colour from orange-yellow (RVG), yellow (KKVG) to green-yellow
(INVG). Microscopical, phytochemical and physicochemical analysis of the leaf was in support of the literature data of
Justicia adhtoda L. A physicochemical study was performed for the formulations with pure ghee as the blank for
comparison. The parameters included, specific gravity, rancidity, melting point, saponification value, iodine value, acid
value, peroxide value, unsaponifiable matter, TLC and HPTLC, FTIR spectroscopy, total Phenolic Content and Total
Flavonoid Content. All the three formulations showed values of similar range, however, KKVG formulation was found to be
more rancid with high peroxide value (6.667±0.067) than RVG (3.4±0.116) and INVG (0.933±0.067). INVG formulation
was found to contain the maximum TPC (72.521±0.113 mg GAE/g) and TFC (14.877±0.247 mg QUE/g) values. In vitro
biological activity was carried out by studying the antioxidant potential using DPPH radical scavenging estimation; RVG
was found to have the least IC50 value (348.000±0.01 μg/mL). Microbiological load and toxicity profile of INVG
formulation were also determined to establish the safety profile of the formulation of Vasa Ghrita
Analysis of Evaluation Parameters of the In-house and Marketed Samples of Rasayana Churna
Full text linkAyurveda, Siddha and Unani systems constitute Indian traditional medicine. For these drugs, analysis of evaluation parameters is very important to ensure safety, quality, purity, stability and efficacy. The herbal drugs should also follow the protocol for standardisation as done for non-herbal formulations. The present paper involves an Ayurvedic formulation rasayana churna. Churna is a fine powder of the drug or drugs in Ayurveda system of medicine. It comprises of the dried powders of three rejuvenating drugs viz dried stem of Guduchi (Tinospora cordifolia Miers.), dried fruit of Gokshur (Tribulus terrestris Linn.) and dried pericarp of Amalaki (Emblica officinalis Gaertn.). All these plants are used in rasayana therapy. Rasayana therapy is an important concept under Ayurveda. Rasayana Churna plays a very important role as an immunomodulator, rejuvenator, adaptogen, antioxidant and diuretic. Other important roles of rasayana churna involve elimination of toxins through urinary system and lowering the risk in kidney and cardiac disorders. The present study aims at analysis of the evaluation parameters of the in-house and marketed samples of rasayana churna such as morphological, microscopical, phytochemical, physicochemical, spectroscopical and biological evaluation parameters. The need of standardisation is evident because variations are obtained in the results. The highest berberine content is found in MRC (1.19 μg/ml). The highest phenolic content is found in MRC (64.29±2.91 mg GAE/g) and highest flavonoid content is found in MRC (18.99±0.40 mg QUE/g). Samples also showed good antioxidant activity and antiurolithiatic activity
Pharmacognostic Evaluation of Vasa Ghrita
Full text linkAdhatoda vasica is a well-known plant in India traditionally used for treatment of cough and cold. Vasa ghrita formulation is prescribed in treatment of bronchial asthma and rakta pitta (blood-bile). The main aim was to standardize the Vasa ghrita formulation which was prepared from Adhatoda vasica leaves and to establish the standard limits for all the parameters evaluated. In this study various parameters were evaluated for the crude vasaka leaves and Vasa ghritas formulation which include in-house Vasa ghritas and two marketed formulations brand RVG and brand KKVG. Morphological evaluation was performed by checking the organoleptic characters. Microscopical study was done to authenticate the drug. Phytochemical screening was done to determine the presence of chemical constituents present in Adhatoda vasica. In physicochemical evaluation many parameters were determined including loss on drying, Ash values, extractive values, swelling index, foaming index, specific gravity, rancidity, melting point, saponification value, iodine value, acid value, peroxide value, unsaponifiable matter, thin layer chromatography and HPTLC, FTIR spectroscopy, TPC, TFC and DPPH radical scavenging activity. Biological study was done to determine microbial load and toxicity profile. Parameters evaluated for crude powder and the Vasa ghritas formulations were within the standard limits. Study proved that the in-house Vasa ghrita was more enriched than branded formulations
