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Condylomes acuminés: traitement avec électrocoagulation et injection intramusculaire d'interféron-b seul ou combiné.
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Dermotossicità da meduse del Mare Adriatico
No full textWe have tested the dermotoxicity of some purified nematocysts preparations of Aurelia aurita, Chrysaora hysoscella, Rhizostoma pulmo, in 25 volunteers by means of scratch-patch test. Our results show the validity of the method used for nematocyst purification. The few skin reactions obtained confirm the low dermotoxicity of the jellyfish studied
Uselessness of topical calcipotriol as monotherapy for acrodermatitis continua of Hallopeau.
No full textEfficacy of intramuscular interferon-ß in reducing relapses in the treatment of male patients with condylomata acuminata
No full textINTRODUCTION Numerous trials using interferon in the treatment of HPV infections have been reported. IFN-β has antiviral, antiproliferative and immunopotentiating activities. The aim of this randomized open study was to evaluate the effectiveness of intramuscular IFN-β in reducing relapses versus both electrocautery and combined treatment, i.e. IFN-β plus electrocautery, in a group of male patients affected by genital warts. PATIENTS AND METHODS A total of 84 male patients (mean age 32 years) with recent genital warts were randomly enrolled into three groups: 33 patients were treated with electrocautery; 25 patients received only intramuscular IFN-β (3 000 000 IU daily for 10 days); 26 patients were treated with both electrocautery and intramuscular IFN-β (3 000 000 IU daily for 10 days). The patients were checked monthly. Residual disease was treated with electrocautery until complete clearance. RESULTS After 1 month 42% of the patients treated with electrocautery, 29% of those treated with TFN-β and 39% of those treated with combined therapy had been cured. Residual disease rates gradually decreased in all groups during the follow-up, but more quickly in the patients who had received IFN-β therapy. No side-effects after IFN-β treatment were observed. CONCLUSION IFN-β monotherapy is not the first choice treatment for genital warts, though it may be useful in patients with relapsing condylomata acuminata resistant to other therapy
Psoriatic arthritis treated with cyclosporin A.
No full textCyclosporin A (CyA) is a very effective immunosuppressor for inhibition of the humoral immune response and especially for cell mediation and was originally indicated for transplantation of organs and autoimmune diseases. More recently, CyA has been used successfully for severe psoriasis. In this study, the authors describe the results obtained from 8 patients who presented with a psoriatic arthropathy, treated with small doses of CyA (3-5 mg/kg/day). There were reactions in five of them, in two patients the Ritchie index decreased moderately and in one patient the arthritic psoriasis was significantly improved
Dermotossicità di una preparazione di nematocisti di Carybdea marsupialis
No full textCarybdea marsupialis (Cnidaria, Cubozoa), a jellyfish found in the Adriatic Sea only in recent years, was previously considered innocuous and only recently has been described by us as dermotoxic to man. In the present study we evaluated the activity of a purified preparation of nematocysts of Carybdea marsupialis in men. A crude nematocystic fraction was tested by prick and patch test in 7 volunteers and by scratch-patch test in 20. In the prick test 0.1 ml of the suspension of nematocysts was applied on forearms, and then a slight prick was made with a needle at the centre of the drop. The reaction was read after 20 min. In the patch test 0.1 ml of nematocysts suspension were applied on forearms and covered by a suitable patch-tape. The reaction was read after 48 and 96 hrs. The scratch patch test consisted in producing a net (1 cm x 1 cm) of 3 vertical and 3 horizontal lines with a needle on the forearms without making it bleed. Then, 0.1 ml of the suspension were put on the scratched area and covered with a patch tape. The reaction was read after 48 and 96 hrs. All volunteers were also tested with distilled water. All the 7 subjects tested by prick and patch test resulted negative, while various degrees of erythema were observed only in 4 subjects tested by scratch-patch test. Our results confirm that Corybdea marsupialis is dermotoxic, even if only subjects with particularly sensitive skin suffer from its sting. This study shows that the procedure of purification we used is valid to maintain the dermotoxic activity of the preparation. The nematocysts separated from their cellular matrix appear unable to penetrate the intact skin, but maintain their capacity to release venom. In fact the purified preparation was inactive if tested in the prick and in the patch test. In contrast, its dermotoxic action was present when the skin barrier was altered as in the scratch-patch test. Therefore, scratch-patch test represents the most suitable method to evaluate the dermotoxicity of purified nematocysts
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