196,307 research outputs found
J. Brooks, M. Mayer, E.S. Herman, N. Wolfson, L.M. Kohlmeier, R. Blodgett, Conflicts of Interest
No full textJ. Brooks, M. Mayer, E.S. Herman, N. Wolfson, L.M. Kohlmeier, R. Blodgett, Conflicts of Interest. In: Revue internationale de droit comparé. Vol. 29 N°3, Juillet-septembre 1977. p. 617
J. Brooks, M. Mayer, E.S. Herman, N. Wolfson, L.M. Kohlmeier, R. Blodgett, Conflicts of Interest
No full textJ. Brooks, M. Mayer, E.S. Herman, N. Wolfson, L.M. Kohlmeier, R. Blodgett, Conflicts of Interest. In: Revue internationale de droit comparé. Vol. 29 N°3, Juillet-septembre 1977. p. 617
Privacy risks and protective measures
No full textProgress in informatics allows for the storage, processing, and interchange of an ever-increasing amount of data. Some important pieces of information (our own genetic code) might become available to multiple users or organizations in years to come and might be used in ecological studies of disease prevalence. The long-term consequences of having genetic codes and biochemical parameters accessible to governmental bodies are not yet known. It is impossible to make long-term predictions, but increased data sharing, with all the caveats exemplified in this chapter, will foster clinical research and in turn benefit patients. On the other hand, we might have to surrender part of our privacy and aim for a mutual sense of progress to harmonize the right to confidentiality with population well-being
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
Gastrointestinal Kohlmeier-Degos disease: a narrative review
No full textINTRODUCTION: Kohlmeier-Degos (K-D) disease is a rare obliterative vasculopathy that can present as a benign cutaneous form or with potentially malignant systemic involvement. The gastrointestinal tract is most frequently involved in systemic disease and mortality is often related to bowel perforations. Herein, we provide information to providers and patients regarding gastrointestinal K-D symptomology, pathology, treatment, and diagnosis, with a focus on the importance of timely diagnostic laparoscopy. We present three new cases of gastrointestinal K-D to highlight varying disease presentations and outcomes.
BODY: Based on reviewed reports, perforation is preceded by at least one gastrointestinal symptom: abdominal pain/cramping, anorexia/weight loss, vomiting, diarrhea, nausea, gastrointestinal bleeding, obstipation, constipation, and abdominal fullness. Perforation most commonly occurs in the small intestine and often results in sepsis and death. Although underutilized, laparoscopy is the most sensitive and specific diagnostic technique, demonstrating serosal porcelain plaques similar to those on the skin and characteristic for K-D. The combination of eculizumab and treprostinil is presently the most effective treatment option for gastrointestinal K-D. The pathology of gastrointestinal K-D is characterized by an obliterative intimal arteriopathy eventuating in occlusive acellular deposits of mucin and collagen along with an extravascular pauci-cellular sclerosing process resembling scleroderma confined to the subserosal fat. C5b-9 and interferon-alpha are both expressed in all caliber of vessels in the affected intestine. While C5b-9 blockade does not prevent the intimal expansion, enhanced type I interferon signaling is likely a key determinant to intimal expansion by, causing an influx of monocytes which transdifferentiate into procollagen-producing myofibroblast-like cells.
CONCLUSION: Prompt laparoscopic evaluation is necessary in any K-D patient with an abdominal symptom to facilitate diagnosis and treatment initiation, as well as to hopefully decrease mortality. Those with gastrointestinal K-D should start on eculizumab as soon as possible, as onset of action is immediate
Nutrients and genes in the liver: The central role of liver x receptor in lipogenesis
No full textDietary fats are an important energy source, which form an essential part of membranes and function as precursors of important molecules, such as hormones. Changes in the dietary fatty acids composition can deeply influence health and susceptibility to diseases. For example, current dietary guidelines discourage consumption of saturated fatty acids and encourage consumption of unsaturated fatty acids such as n-3 fatty acids that are contained in fish oil. N-3 fatty acids intake is associated with decreased plasma triglyceride concentrations and cardiac arrhythmias prevention. Dietary fatty acids, like other nutrients, are able to influence biological processes by altering DNA transcription through nuclear receptors. Specifically, the liver X receptor (LXR) exerts a main function in liver fatty acids metabolism via sterol regulatory element-binding protein 1c (SREBP1c) and carbohydrate response element-binding protein (ChREBP). Alterations on this nuclear receptor may alter normal metabolism and contribute to the pathogenesis of various diseases
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
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