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Interleukin-10 Deficiency Drives the Development of Mouse B cell Leukemia/Lymphoma
No full textExcessive inflammatory responses to common childhood infections are associated with an increased risk of pediatric B cell Acute Lymphoblastic Leukemia (B ALL). Despite the identification of several neonatal inflammatory markers as B ALL risk factors, the mechanism(s) by which these markers stimulate an excessive immune response leading B ALL remain largely unknown. Here, we demonstrate that IL 10 deficiency, a neonatal risk factor for B ALL, indirectly impairs B lymphopoiesis and increases B cell DNA damage through induction of inflammation in mice. Altered B cell number and DNA damage in Il10-/- mice were associated with a module of 6 pro inflammatory/myeloid associated cytokines (IL-1, IL-6, IL-12p40, IL 13, CCL4/MIP 1, and G CSF). Importantly, inflammation and defects in bone marrow B cells were attenuated by treating pre leukemic Il10-/- Ckdn2a-/- mice with antibiotics that target Helicobacter species. In the TEL AML1 Ckdn2a-/- mouse model of B ALL, decreased levels of IL-10 accelerated B cell neoplasms in a dose dependent manner, and altered the mutational profile of B cell neoplasm to favor C>T and T>C mutations. Infection of Cdkn2a-/- mice to Aspiculuris, a parasite that induces IL-10 production, delayed the development of B cell neoplasms in Cdkn2a / mice, demonstrating a novel protective effect of microbial exposure. Our results identify commensal bacteria as modulators of bone marrow B cell responses to IL 10 deficiency, and suggest that microbial dysbiosis underlies the infectious etiology of pediatric B ALL
A planning study for the William G. Scott House in Richmond, Indiana
No full textThe William G. Scott House in Richmond, Indiana was built c. 1885 for William G. Scott and his wife, Clara A. Robie McCoy. Mr. Scott, who was a successful executive at the prosperous steam engine manufacturing company Gaar, Scott & Co., was hailed as having one of the most prominent and beautiful homes within the city. The Scott family occupied the house until Mr. Scott's death in 1897, and the property was passed down to several Scott family descendants. In 1921, Richmond's local chapter of the Knights of Columbus purchased the Scott House and converted the building into their clubhouse. The Knights of Columbus continue to own and occupy the property today.The Knights of Columbus made several significant changes to house over the past eighty-two years, including installing a ceramic tile floor on the first floor, creating a Lodge Room on the third floor, remodeling the basement and the kitchen, and building a modern 5,000 sq. ft. meeting hall on the west side of the house. After the new meeting hall was constructed, the Knights of Columbus utilized the new addition most often, rather than the old clubhouse, and the historic Scott House was left vacant and allowed to slip into disrepair.Today, the Knights of Columbus use the Scott House to host "Tea Room Luncheons" featuring traditional Victorian menu items and local entertainment to revitalize public interest in historic architecture and generate funds for the future rehabilitation of the Scott House. The organization is also exploring future uses for the property and identifying additional fundraising opportunities, in hopes of rehabilitating the Scott House and restoring the property to its original elegance and grandeur.The Planning Study for the Scott House contains a history of the property, illustrations, elevation and floor plan drawings, building condition assessments, recommended treatment methods, and suggested maintenance practices. For further reference, the author's building assessment forms and annotated assessment drawings, and the Secretary of the Interior Standards for the Treatment of Historic Properties are included as appendices.This project was primarily an academic exercise and intended to help the author learn the process of evaluating the condition of a building, proposing treatment methods and maintenance practices, and writing a preservation planning study. In addition, the report is intended to serve as an outline and reference guide for Knights of Columbus to help direct the organization with the future rehabilitation, preservation, and maintenance of the William G. Scott House.Thesis (M.S.H.P.)Department of Architectur
Belonging and not belonging : understanding India in novels by Paul Scott, Ruth Prawer Jhabvala and V.S. Naipaul.
No full textPhDThis thesis is essentially about the "how" and "why" of the Indian
experience as documented in novels by Paul Scott, Ruth Prawer Jhabvala
and V S Naipaul. The study points to the difficulty of arriving at any
conclusive definition of the country and its people. I show that
differences in attitudes, responses or behaviour are both overt and
subtle, and depend upon whether the writer or the character identifies
with the situation or community with which he or she interacts. It is
the individual's sense of belonging or not belonging to his or her own
group - be this along racial, cultural or gender lines - that accounts
for the differing perspectives evident in these novels. The points-of-
view of the outsider and the insider can therefore be seen as
mutual comments upon the other.
Since the struggle between belonging and not belonging becomes acute
when the old meets the new, focus is centred on communities
experiencing change. These include the British in India, West-Indian
Indians and westernised Indians. Despite their differences, all three
communities share similar reasons for either an acceptance or
rejection of the 'Other'. The thesis argues that the need for
emotional stability compels allegiance to the traditional group, while
the desire for individuality encourages surrender to the new. The
former nurtures a sense of belonging while, it is argued, that the
latter is perceived as the hallmark of those who do not belong.
Tensions arise when both these needs demand to be met. What I show to
be ironic in this struggle between belonging and not belonging is that
those things which individuals overtly reject are often unexpressed
parts of their personal pysche. The barrier between "them" and "us" is
therefore very fragile
The oral nature of the Homeric simile
No full textThis work, by Dartmouth Professor Emeritus William Scott, centers on Homer\u27s similes as compositions derived from, and dependent on, an oral tradition.
About the Author
William C. Scott is emeritus professor of classics at Dartmouth College. His other publications include The Artistry of the Homeric Simile, Musical Design in Aeschylean Theater, Plato\u27s The Republic with Richard W. Sterling, and Musical Design in Sophoclean Theater.
About the Electronic Publication
This electronic publication of The Oral Nature of the Homeric Simile was made possible with the permission of the author. The University Press of New England created EPUB and PDF files from a scanned copy of the book.
Rights Information
Creative Commons Attribution-NonCommercial License © William C. Scot
Kenilworth : a romance
No full textby the author of "Waverley", "Ivanhoe", &c [Walter Scott]Bd. 1: 321 Seiten, [1] Blatt ; Bd. 2: 343 Seiten, [2] Blätter ; Bd. 3: 348 Seite
The evolution of surfaces and their measurement
No full textSurfaces and their interactions are at the heart of living systems and all moving objects.
They have fascinated man from the ancient Egyptians, through Leonardo Da Vinci in the
Renaissance period, to nanotechnologists of today. This paper elucidates the science of
surfaces and their interactions, covering the importance of surfaces and how they influence us
all in terms of energy, environment and quality of life. It attempts to uncover the story of
mankind‟s deepening understanding of surfaces and their measurement, and to provide an
overview of surface measurement and shows how current thinking has evolved from a
complicated historical background
Footloose in Jacksonian America: Robert W. Scott and his Agrarian World
No full textIn the fall of 1829, young Robert Wilmot Scott rode away from Frankfort, Kentucky, on a trip that would take him through nine states. His journal entries about those travels present a vivid picture of Jacksonian America and of the prominent people of that era. Excellent pen portraits of James and Dolly Madison, James Monroe, John Marshall, James Buchanan, Sam Houston, Edward Everett, John C. Calhoun, John Randolph, John Quincy Adams, and others show Scott to be a careful and detailed observer. Present at the famous Webster-Hayne debate, he gives a rich account of that discussion and its personalities.
But not only people attracted Scott’s observations. In visits to Richmond, New York, Boston, Philadelphia, Washington, D.C., and Pittsburgh, among other places, he gave close attention to public buildings, universities, theaters, churches, and manufacturing establishments. His comments on culture and industry detail the quickening pulse of a burgeoning nation, and compare favorably with more familiar accounts by James Silk Buckingham or Thomas Hamilton.
In the second half of this work, author Thomas D. Clark traces the later life of this fascinating diarist. Scott became master of a model Kentucky plantation, “Locust Hill,” and proved to be an important agricultural reformer. He was active, as well, in education and in politics. In outlining the career of this agrarian, Dr. Clark has made an important contribution to the study of southern agriculture and the men who shaped it. Scott, in his diary comments, made his own contribution to history by offering fine insights about the world in which he lived.https://uknowledge.uky.edu/upk_united_states_history/1122/thumbnail.jp
Interview with James C. Scott: Egalitarianism, the teachings of fieldwork and anarchist calisthenics
No full textJ
ames C. Scott is Sterling Professor of Political Science and Anthropology at Yale University
where he directs the Program in Agrarian Studies. Author of foundational books on
the fields of Agrarian studies and Social Movements (but with a wider resonance in other
domains of social sciences), namely The Moral Economy of the Peasant: Rebellion and Subsistence
in Southeast Asia (1977), Weapons of the Weak: Everyday Forms of Peasant Resistance (1985),
and Domination and the Arts of Resistance: Hidden Transcripts (1990), Scott recently published
The Art of Not Being Governed: An Anarchist History of Upland Southeast Asia (2009). His work
has been a major source of inspiration for the four of us and we therefore invited him to visit
Portugal in order to discuss some of the key-elements of his research.James C. Scott visited Portugal to participate in the research activity of the fct project
“The Making of State Power in Portugal 1890-1986” (ptdc/his-his/104166/2008). Besides the
financial support of fct, Scott’s visit also benefited from the financial support of fla
Interview with James C. Scott: Egalitarianism, the teachings of fieldwork and anarchist calisthenics
No full textJ
ames C. Scott is Sterling Professor of Political Science and Anthropology at Yale University
where he directs the Program in Agrarian Studies. Author of foundational books on
the fields of Agrarian studies and Social Movements (but with a wider resonance in other
domains of social sciences), namely The Moral Economy of the Peasant: Rebellion and Subsistence
in Southeast Asia (1977), Weapons of the Weak: Everyday Forms of Peasant Resistance (1985),
and Domination and the Arts of Resistance: Hidden Transcripts (1990), Scott recently published
The Art of Not Being Governed: An Anarchist History of Upland Southeast Asia (2009). His work
has been a major source of inspiration for the four of us and we therefore invited him to visit
Portugal in order to discuss some of the key-elements of his research.James C. Scott visited Portugal to participate in the research activity of the fct project
“The Making of State Power in Portugal 1890-1986” (ptdc/his-his/104166/2008). Besides the
financial support of fct, Scott’s visit also benefited from the financial support of fla
Una aproximación teórica a James C. Scott. Cuicuilco Revista de la Escuela Nacional de Antropología e Historia: Raza, fobias e intolerancias. Num. 31 (2004) Vol. 11 mayo-agosto
No full textEn este trabajo se retoman las aportaciones más relevantes de la obra de James C. Scott: los conceptos de las relaciones de poder, la hegemonía, la resistencia y la subordinación, los cuales aparecen plasmados en su libro más relevante, Los dominados y el arte de la resistencia, a fin de insistir, con base en el modelo expuesto por el doctor Manuel Gándara para el análisis del conocimiento, en las contradicciones intrínsecas a los planteamientos de Scott, todo ello según la teoría de que el conocimiento es falible pero perfectible.James C. Scott´s most outstanding contributions in his works are: power relations, hegemony, resistance and subordination. These concepts are used in his excellent book: Los dominados y el arte de la resistencia, and I of insist that I was based in doctor Manuel Gándara´s Understanding Analysis Model, in the intrinsical contradictions to such statements given by Scott, and in accordance to the theory that understanding is subject to error (is fallible), but can be improved (is perfectible).Bordieu, Pierre. 1997. Razones prácticas. Sobre la teoría de la acción, Barcelona, Anagrama.Chartier, Roger. 1995. El mundo como representación. Historia cultural: entre práctica y representación, Gedisa.Chavero, Rosalía. 1997. Voces y silencios en la historia, siglos XIX y XX, México, FCE.Cruz, Manuel. 1991. filosofía de la historia, Barcelona, Paidós.De Certeau, Michel. 1993. La escritura de la historia, México, Universidad Iberoamericana.Foucault, Michel. 1979. Microfísica del poder, Madrid, La Piqueta.Foucault, Michel. 1987. Vigilar y Castigar, México, Siglo XXI.Foucault, Michel. 1991. Saber y Verdad, Madrid, La Piqueta.Foucault, Michel. 1992. Genealogía del racismo, Madrid, La Piqueta.Gadamer, H. G. 1998. El giro hermenéutico, Madrid, Cátedra.Gándara Vázquez, Manuel. 1990. “Algunas notas sobre el análisis del conocimiento”, en Antropología Americana, México, Instituto Panamericano de Geografía e Historia, boletín núm. 22, pp. 5-19.Gándara Vázquez, Manuel. 1993. “El análisis de posiciones teóricas: aplicaciones a la Arqueología Social”, en Antropología Americana, México, 27 de julio, pp. 5-20.Hollis, Martin. S/f. “Systems and functions”, en The Philosophy of Social Science, an Introduction, Cambridge University Press, pp. 94-114.Moore, Barrington. 1990. La injusticia: bases sociales de la obediencia y la rebelión, México, Instituto de Investigaciones Sociales-UNAM.Navarro, D. 2001. “Sobre los intelectuales y la crítica social en la esfera pública cubana”, en La Habana Elegante, segunda .poca, versión electrónica en http://www. habanaelegante.com/Winter2001/Verbosa.html.Ramírez, J. A. 1986. La polémica de la postmodernidad, Madrid, Libetarias.Rorty, Richard. 1996. Objetividad, relativismo y verdad, Barcelona, Paidós.Salmon, Wesley C. s/f. “Scientific Explanation”, en Introduction to the Philosophy of Sciences, Nueva Jersey, Prentice Hall, pp. 1-103.Scott, James C. 1990. Los dominados y el arte de la resistencia. Discursos ocultos, México, Era.Scott, James C. 1998. Seeing Like a State: How Certain Schemes to Improve the Human Condition Have Failed, New Haven y Londres, Yale University Press
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