1,720,991 research outputs found
Ergebnisse der operativen Behandlung bei degenerativer lumbaler Spinalkanalstenose - eine retrospektive Analyse
No full textAim: The intention of this retrospective analysis with follow-up was to assess results after decompressive or additional stabilising operations in the clinical setting of degenerative lumbar spinal stenosis. Method: 74 patients, operated upon from 1995 to 2001, were investigated clinically, radiologically and with questionnaire score 1 to 8 years (mean 2.5) postoperatively. All data were compared and evaluated with the preoperative findings. The results of the group with decompressive operations were compared with those for the group with additional stabilising operations. Results: The patients with stabilising operations showed an improvement of 78.3% on the visual analogue scale and of 76.1% on the Oswestry score. The patients with decompressive operations showed an improvement of 91.7% on the visual analogue scale and of 75.0% on the Oswestry score. The difference between the two groups was not significant. There was a poorer outcome for previously operated patients or patients with a prolonged course of disease. Conclusion: The choice of the operative treatment with regard to spinal stenosis requires a differentiated preoperative diagnostic procedure in accord with the respective living situation and age of the patients. Instability in terms of degenerative spondylolisthesis, lumbar scoliosis as well as intraoperatively recognised or generated instability has to be additionally stabilised with an instrumented fusion in regard to the functional aspect of the stenosis
Remyelination capacity of the MS brain decreases with disease chronicity
No full textObjective: To analyze and compare the extent of remyelination in lesions from patients with multiple sclerosis (MS) who have a short (early MS lesions) or a long (chronic MS lesions) disease duration and to determine the influence of anatomic localization on the extent of remyelination. In early MS lesions, remyelination has been described as a relatively frequent event, in contrast to chronic MS lesions, where remyelination is absent or limited to the lesion border in the majority of lesions. However, no studies have been published that have quantified and compared the extent of remyelination in early and chronic MS lesions. Methods: We analyzed the occurrence of remyelination in 52 biopsies from 51 patients (early MS) and in 174 lesions from 36 autopsy cases (chronic MS) by immunohistochemistry for myelin proteins, and correlated our findings with anatomic localization, sex, age, and disease duration. Results: Significantly more lesions were remyelinated in early than in chronicMS (80.7% vs 60%). In chronic MS, subcortical lesions showed more extensive remyelination than periventricular lesions. The majority of cerebellar lesions were completely demyelinated. Conclusion: In summary, our data demonstrate that remyelination is a frequent event in early multiple sclerosis lesions. Furthermore, the anatomic localization of a lesion might influence the extent of remyelination. Neurology (R) 2009; 72: 1914-192
Persistence of immunopathological and radiological homogeneity in a patient with relapsing-remitting multiple sclerosis
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CCR5 expression on macrophages/microglia is associated with early remyelination in multiple sclerosis lesions
No full textRemyelination in multiple sclerosis (MS) occurs spontaneously and extensively. The underlying mechanisms, however, are only partly understood. Findings in experimental animal settings suggest that inflammation promotes remyelination and repair. Here, we characterized the chemokine receptor expression profiles of macrophages/microglia in early remyelinating and completely remyelinated lesions compared with active demyelinating and inactive demyelinated MS lesions obtained in the early disease course. Biopsy material consisting of 16 MS cases was available for this study. We found that macrophages/microglia within early remyelinating lesions expressed predominantly CCR5. Our findings implicate a possible role of CCR5+ cells in initiating remyelination.NINDS NIH HHS [P01 NS38667
Neuroaxonal regeneration is more pronounced in early multiple sclerosis than in traumatic brain injury lesions
No full textThe extent of irreversible neuroaxonal damage is the key determinant of permanent disability in traumatic and inflammatory conditions of the central nervous system (CNS). Structural damage is nevertheless in part compensated by neuroplastic events. However, it is unknown whether the same kinetics and mechanisms of neuroaxonal de- and regeneration take place in inflammatory and traumatic conditions. We analyzed neuroaxonal degeneration and plasticity in early multiple sclerosis (MS) lesions and traumatic brain injury (TBI). Neuroaxonal degeneration identified by the presence of SMI31+ chromatolytic neurons and SMI32+ axonal profiles were characteristic features of leukocortical TBI lesions. Axonal transport disturbances as determined by amyloid precursor protein (APP)+ spheroids were present in both TBI and MS lesions to a similar degree. Neurons expressing growth-associated protein 43 (GAP43) and synaptophysin (Syn) were found under both pathological conditions. However, axonal swellings immunopositive for GAP43 and Syn clearly prevailed in subcortical MS lesions, suggesting a higher regenerative potential in MS. In this context, GAP43+/APP+ axonal spheroid ratios correlated with macrophage infiltration in TBI and MS lesions, supporting the idea that phagocyte activation might promote neuroplastic events. Furthermore, axonal GAP43+ and Syn+ swellings correlated with prolonged survival after TBI, indicating a sustained regenerative response
Comparative study of neuronal and axonal pathology in early multiple sclerosis and CNS trauma lesions
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