4,138 research outputs found
A Comparative Study of Modern Homology Modeling Algorithms for Rhodopsin Structure Prediction
No full textRhodopsins
are seven α-helical membrane proteins that are
of great importance in chemistry, biology, and modern biotechnology.
Any in silico study on rhodopsin properties and functioning requires
a high-quality three-dimensional structure. Due to particular difficulties
with obtaining membrane protein structures from the experiment, in
silico prediction of the three-dimensional rhodopsin structure based
only on its primary sequence is an especially important task. For
the last few years, significant progress was made in the field of
protein structure prediction, especially for methods based on comparative
modeling. However, the majority of this progress was made for soluble
proteins and further investigations are needed to achieve similar
progress for membrane proteins. In this paper, we evaluate the performance
of modern protein structure prediction methodologies (implemented
in the Medeller, I-TASSER, and Rosetta packages) for their ability
to predict rhodopsin structures. Three widely used methodologies were
considered: two general methodologies that are commonly applied to
soluble proteins and a methodology that uses constraints that are
specific for membrane proteins. The test pool consisted of 36 target-template
pairs with different sequence similarities that was constructed on
the basis of 24 experimental rhodopsin structures taken from the RCSB
database. As a result, we showed that all three considered methodologies
allow obtaining rhodopsin structures with the quality that is close
to the crystallographic one (root mean square deviation (RMSD) of
the predicted structure from the corresponding X-ray structure up
to 1.5 Å) if the target-template sequence identity is higher
than 40%. Moreover, all considered methodologies provided structures
of average quality (RMSD < 4.0 Å) if the target-template sequence
identity is higher than 20%. Such structures can be subsequently used
for further investigation of molecular mechanisms of protein functioning
and for the development of modern protein-based biotechnologies
Life and work of academician Vladimir Bayer
No full textAkademik Vladimir Bayer, učenik gimnazije u Osijeku, redoviti profesor na katedri Kazneni postupak Pravnog fakulteta Sveučilišta u Zagrebu i redoviti član JAZU-a, od 1986. jedan je od najistaknutijih i najcjenjenijih hrvatskih pravnika. Autor je brojnih zanstvenih i stručih radova iz procesnog i materijalnog kaznenog prava, povijesti kaznenog prava, penologije i pravne nastave. Znatan dio njegova znanstvenog djela ugrađen je u zakonske propise. Zastupa ideje pravnopolitički liberalno usmjerene teorije kaznenog prava i suglasno tome zalaže se za postavljanje preciznih i čvrstih granica represivnih ovlasti državnih tijela. Zajedno s profesorom Bogdanom Zlatarićem utemeljitelj je uglednog Poslijediplomskog studija iz kaznenopravnih znanosti Pravnog fakulteta Sveučilišta u Zagrebu.The academician Vladimir Bayer, who attended secondary-school in Osijek and has been professor at the Chair of Criminal Procedural Law at the Faculty of Law in Zagreb, University of Zagreb has also been a regular member of JAZU since 1986. He is one of the most significant and highly regarded Croatian jurists, the author of a number of scientific, expert papers in the field of procedural and material criminal law, history of criminal law, penology and law teaching. His scientific work makes a considerable integral part of legal regulations. He stands for the criminal law theory of legal-political liberal orientation and accordingly for setting precise and firm boundaries to repressive powers of the authorities. He established together with professor Bogdan Zlatarić the renowned postgraduate studies in criminal law science at the Faculty of Law in Zagreb
Names of Vladimir the Great in Liturgical Texts and the Perception of his Sainthood in the 14th and 17th Centuries
No full textThe article examines attributive and agentive names of the grand prince of Kiev, Vladimir Svyatoslavich as they appear in liturgical texts of the 14th and 17th centuries, that either circulated independently or were employed at church services especially dedicated to the saint. Presuming that the first laudatory songs glorifying Vladimir date back to the 12th century, the author observes the steady increase of the number of such attributive and agentive names in liturgical texts and marks the period from the 14th through the 17th centuries as a peak of textual activity surrounding Vladimir. As the tables included in the article indicate, the increase in number was accompanied by the corresponding increase in semantic and imagery complexity. The names, employed in broader contextual meanings, became associated with various semantic fields and, above all, began to express abstract ideas related to the ideal vision of the personality of the saint and its historical, metaphysical, and spiritual dimensions
Ivan IV and Vladimir Staritsky: Political Struggle or Competition in Piety?
No full textIntroduction. The author researched and prepared for publication four acts of 1547–1566 issued by Ivan IV and the appanage prince Vladimir Andreevich on the villages of the Trinity-Sergius Monastery in Vereysky and Dmitrov counties. The diplomas are studied in the context of the corpus of act and narrative sources, containing the plot of the relationship of the appanage prince with his suzerain. Methods and materials. The task of this article is to clarify the real participation of Prince Vladimir in the political and administrative life of the country for three years from 1566 to 1569 and is solved by a comprehensive analysis of narrative texts and the act material in which the real prerogatives of the appanage prince are documented. Analysis. An indicator of Vladimir Staritsky’s administrative and political activity is the intensity and nature of the charters issued and preserved by him, and their correlation with the acts of Ivan IV, to which the key part of the article is devoted. Results. It has been established that in addition to the acts drawn up in the office of the appanage prince relatively independently, acts have been preserved in the compilation of which protographs were used. When creating the acts in 1566, the offices of the tsar and the appanage prince used the letters of 1547 and 1548, the form of which was reproduced without significant changes. It is hypothesized that the acts of Prince Vladimir Andreevich and Ivan IV indicate a kind of competition in piety between the autocratic monarch and the prince of the blood
Russian Revolution, Vladimir Lenin
No full textAn image scanned from a black and white photograph of Vladimir Lenin walking down the street and a woman behind him. Within a series of photographs saved by author Arnold Rubenstein of Trotsky and Lenin.https://digitalcommons.library.umaine.edu/spec_photos/3507/thumbnail.jp
Russian Revolution, Vladimir Lenin at a Meeting
No full textAn image scanned from a black and white photograph of Vladimir Lenin and others at a long table. Stacks of papers are spread out before them. Within a series of photographs saved by author Arnold Rubenstein of Trotsky and Lenin.https://digitalcommons.library.umaine.edu/spec_photos/3503/thumbnail.jp
Vladimir Burtsev and the Russian revolutionary emigration: surveillance of foreign political refugees in London, 1891-1905.
No full textPhDThe thesis describes the early life in emigration of the Russian revolutionary, historian
and radical journalist Vladimir L'vovich Burtsev (17/29 November 1862 - 21 August
1942). Particular emphasis is placed on the nature and extent of the police
surveillance of Burtsev and the émigré community in Europe during the period. The
relationship between the Criminal Investigation Department of London's
Metropolitan Police and their Russian counterparts in Europe - the Zagranichnaia
agentura, ('Foreign Agency') - is examined in detail.
Burtsev's biography has great contemporary relevance, unfolding, as it does, in an
atmosphere of increasing anxiety in Britain (both governmental and non-official)
about growing numbers of foreign anarchists, terrorists, and `aliens' in general (which
would lead, in due course, to the passing of the 1905 Aliens Act) and the increasingly
interventionist police methods of the era. The thesis describes Burtsev's relationship
with the émigré community and its British supporters, examines his (at times extreme)
political views and reviews the radical journalism which led to his trial and
imprisonment in 1898. This, the `Burtsev affair', signalled a major shift in British
government policy towards political refugees on the one hand and to international
counter-terrorist co-operation on the other and it is one of the aims of this thesis to
detail the reasons for these changes
A CRITICAL ANALYSIS OF DOCTORAL RESEARCHES (2010-2014) ABOUT WORKS OF VLADIMIR VYSOTSKY
No full textThis article concludes an overview of reaserches about works of Vladimir Vysotsky (vysotskovedeniye), that had been written by this moment. I also had made a careful study of doctoral researches about works of Vladimir Vysotsky. There is also a critical analysis of doctoral researches, that had been protected in 2010-2014.For the first time in the science about «bard song», all doctoral researches about Vladimir Vysotsky compiled and systematized by author. These works investigated from a statistical, geography of creation and belonging to the different scientific branches perspective. Dissertational researches in recent years were analyzed in order to determine their relevance, information availability about the development of «vysotskovedenie» and history of profile issue. Works without references to the previous experience of studying the matter under consideration, as well as containing a plagiarism were detected among them
VLADIMIR AXIONOV — A CORYPHAEUS OF MOLDOVAN MUSICOLOGY
No full textThe present article is dedicated to Vladimir Axionov, a remarcable musicologist, researcher, educator, animator of musical life in the Republic of Moldova. The author has revealed his innovations in the field of musicology concerning the problems of style, genre and the evolution of contemporary composition creation
'Christian Faith' by Prince Vladimir the Great: Fluctuations of abstract lexemes
No full textAccording to Russian chronicles, Prince Vladimir the Great, being baptized in Chersones in 986, pronounced in Slavonic two confessions of faith – the well-known Credo Niceo-Constantinopolitanum and the second confession, which has been unknown until the recent time and highly enigmatic. It is obvious that the second “faith” was translated from Greek, but the Byzantine text was found only in the middle of the 19th century. Prince Vladimir professed the sc. li,belloj (Lat. deminutivum libellus – knizhitsa (книжица 'little book')) written (about 835) by Michael the Synkellos, the prominent 'great confessor', (o` me,gaj o`mologhth,j). The Slavonic translation is very interesting as a linguistic source and, nevertheless, rather neglected by specialists. The Slavonic versions of Michael's “Libellus” represent five separate translations undertaken in different historical periods (in the span of six centuries) and at different territories – both South- and East-Slavic. Common for all five versions is the great variability of abstract lexemes. The linguistic nature of intensive variability cannot be reduced to the known mechanisms. So, the author of the investigation has introduced a new terminus technicus (fluctuation) to designate the observed phenomenon of theological termination (=creation and competition of termini as a part of language-building activity). A long comparative list of lexical variants (being items in the process of mentioned fluctuation) has been added to the theoretical argumentation
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