1,722,422 research outputs found
Philippe Bieber, Le protestantisme dans l'arrondissement de Sarreguemines. (Extrait de l'ouvrage de Joseph Rohr, L'Arrondissement de Sarreguemines). 1966
No full textKoch G. Philippe Bieber, Le protestantisme dans l'arrondissement de Sarreguemines. (Extrait de l'ouvrage de Joseph Rohr, L'Arrondissement de Sarreguemines). 1966. In: Revue d'histoire et de philosophie religieuses, 51e année n°1,1971. p. 117
Paul Christophe, Cassien et Césaire, prédicateurs de la morale monastique. Collection : « Recherches et synthèses » — section de morale, 1969
No full textKoch G. Paul Christophe, Cassien et Césaire, prédicateurs de la morale monastique. Collection : « Recherches et synthèses » — section de morale, 1969. In: Revue d'histoire et de philosophie religieuses, 51e année n°2,1971. p. 235
Philippe Bieber, Le protestantisme dans l'arrondissement de Sarreguemines. (Extrait de l'ouvrage de Joseph Rohr, L'Arrondissement de Sarreguemines). 1966
No full textKoch G. Philippe Bieber, Le protestantisme dans l'arrondissement de Sarreguemines. (Extrait de l'ouvrage de Joseph Rohr, L'Arrondissement de Sarreguemines). 1966. In: Revue d'histoire et de philosophie religieuses, 51e année n°1,1971. p. 117
Cortico-cortical connectivity: the road from basic neurophysiological interactions to therapeutic applications
No full textTranscranial magnetic stimulation (TMS) based methods are emerging as a unique approach to evaluate in real-time brain electrical activity in healthy and pathological conditions. By applying TMS pulses in two different bran areas within a short temporal frame of few milliseconds, it is possible to investigate their physiological interactions. These paradigms, collectively termed dual-site TMS, have been inspired by Professor John Rothwell’s work, based on the idea that applying a conditioning stimulus over a cortical area may activate putative pathways projecting onto a second target area, thus providing a unique opportunity to test the causal effects between interconnected brain areas. This review highlights the most important features of dual-coil TMS protocols, mainly pioneered in Professor John Rothwell's lab. In the first part, I reviewed development of dual-site TMS protocols leading to the discovery of a distributed system of short-latency interactions within the human parieto-frontal network, likely mediated by direct anatomical pathways. In the second part, the physiological role of these dual-site TMS evoked pathways is considered, describing how these functional interactions are not fixed but vary depending on the brain activation, the condition and on the precise time window in which they are explored. Then, I reviewed recent advances showing that the repeated coupling of interconnected neuronal populations, by means of dual-coil TMS, is able to induce spike-time-dependent plasticity and to determine selective potentiation of physiological connectivity between two human brain regions. Finally, the therapeutic implications of these novel discoveries are discussed, pointing to multi-site TMS as a novel tool to identify early features of synaptic dysfunctions, to monitor disease progression and potentially to provide novel therapeutic approaches by reshaping plasticity in different neurological and psychiatric conditions
Response letter to comments on "Cortico-cortical connectivity: the road from basic neurophysiological interactions to therapeutic applications" by Zibman and Zangen
No full textNo abstract availabl
RTMS effects on levodopa induced dyskinesias in Parkinson's disease patients: Searching for effective cortical targets
No full textLong-term therapy with levodopa and dopamine agonists in Parkinson’s disease (PD) patients is complicated by the
development of fluctuations in motor response, such as levo-dopa induced dyskinesia (LID). Repetitive Transcranial Magnetic
Stimulation (rTMS) has been recently put forward as a possible therapeutic tool able to LID in PD. Trains of 1 Hz rTMS applied
either over the supplementary motor area (SMA) or the primary motor cortex (M1) were able to induce a transient reduction in
the severity of LID, confirming that an over-activity of these areas plays a crucial role in the pathophysiology of LID. However,
repeated sessions of rTMS were not effective in inducing persistent beneficial clinical effects. Functional or metabolic changes
have been reported in the cerebellum in studies in PD patients treated with procedures known to alleviate LID, such as deep brain
stimulation. Therefore, the effects of rTMS applied over the lateral cerebellum has been recently tested in patients with LID. A
two-week course of bilateral cerebellar rTMS induced persistent clinical beneficial effects, reducing peak-dose LID for up to four
weeks after the end of the daily stimulation period. These findings demonstrate that rTMS is a potential tool in individuating the
best cortical targets and the optimal parameters of stimulation able to improve LID in dyskinetic PD patients.Long-term therapy with levodopa and dopamine agonists in Parkinson's disease (PD) patients is complicated by the development of fluctuations in motor response, such as levo-dopa induced dyskinesia (LID). Repetitive Transcranial Magnetic Stimulation (rTMS) has been recently put forward as a possible therapeutic tool able to LID in PD. Trains of 1 Hz rTMS applied either over the supplementary motor area (SMA) or the primary motor cortex (M1) were able to induce a transient reduction in the severity of LID, confirming that an over-activity of these areas plays a crucial role in the pathophysiology of LID. However, repeated sessions of rTMS were not effective in inducing persistent beneficial clinical effects. Functional or metabolic changes have been reported in the cerebellum in studies in PD patients treated with procedures known to alleviate LID, such as deep brain stimulation. Therefore, the effects of rTMS applied over the lateral cerebellum has been recently tested in patients with LID. A two-week course of bilateral cerebellar rTMS induced persistent clinical beneficial effects, reducing peak-dose LID for up to four weeks after the end of the daily stimulation period. These findings demonstrate that rTMS is a potential tool in individuating the best cortical targets and the optimal parameters of stimulation able to improve LID in dyskinetic PD patients. © 2010 IOS Press and the authors. All rights reserved
Cortical Connections to Motor Cortex and Their Modulation in Behavioural Tasks
No full textCortico–cortical connections that reach the primary motor cortex (M1) are thought to transmit crucial information relevant to build the final motor output required to perform a selected motor plan. These connections originate from key areas of the parietal and frontal lobes, such as the posterior parietal cortex (PPC), the supplementary motor area (SMA) and the ventral (PMv) and dorsal premotor cortex (PMd). Multifocal transcranial magnetic stimulation (TMS) has been recently investigated as a powerful method able to track within millisecond time scale direct information on the causal functional connectivity of these non-primary motor areas with the M1 that would explain how their activity may modulate the spatial pattern of output from primary motor areas preceding execution of a movement. A conditioning stimulus (CS) is first used to activate putative pathways to the motor cortex from, for example, the PPC or the PMd, while a second, test stimulus (TS), delivered over the M1 a few milliseconds later probes any changes in excitability that are produced by the CS. When tested at rest, the activation of these cortico–cortical projections may induce both a transient facilitation and a inhibition in the M1 ipsilateral or contralateral to the site of conditioning. However these interactions are not fixed, but may change critically during a certain motor task, giving important information on how the strength of the connection changes over time and during a specific task, and providing crucial information on the causal effects that a specific cortical region exerts over the M1. Moreover, it is possible to combine these measurements of functional connectivity together with diffusion tensor magnetic resonance imaging (DTI) to obtain insight into the white matter pathways that mediate these interactions. Here, we review studies describing the functional role of parallel cortico–cortical connections among the PMd, PMv, PPC and M1 in specific motor tasks such as action selection, action reprogramming, action observation and goal- directed reaching and grasping movements, showing that the functional interplay between these areas is not fixed, but is promptly activated depending on the behavioural state.Cortico-cortical connections that reach the primary motor cortex (M1) are thought to transmit crucial information relevant to build the final motor output required to perform a selected motor plan. These connections originate from key areas of the parietal and frontal lobes, such as the posterior parietal cortex (PPC), the supplementary motor area (SMA) and the ventral (PMv) and dorsal premotor cortex (PMd). Multifocal transcranial magnetic stimulation (TMS) has been recently investigated as a powerful method able to track within millisecond time scale direct information on the causal functional connectivity of these non-primary motor areas with the M1 that would explain how their activity may modulate the spatial pattern of output from primary motor areas preceding execution of a movement. A conditioning stimulus (CS) is first used to activate putative pathways to the motor cortex from, for example, the PPC or the PMd, while a second, test stimulus (TS), delivered over the M1 a few mi..
Nicole Peremans, Erasme et Bucer d'après leur correspondance. « Bibliothèque de la Faculté de Philosophie et Lettres de l'Université de Liège », n° 194. Paris, Les Belles Lettres, 1970
No full textKoch G. Nicole Peremans, Erasme et Bucer d'après leur correspondance. « Bibliothèque de la Faculté de Philosophie et Lettres de l'Université de Liège », n° 194. Paris, Les Belles Lettres, 1970. In: Revue d'histoire et de philosophie religieuses, 52e année n°4,1972. Aperçu sur le passé de quelques minorités religieuses. p. 511
Karl Barth, La prière d'après les catéchismes de la Réformation. 3e édition. Collection : « Foi Vivante », n° 52. 1967 L.-J. Lebret, Appels au Seigneur. Collection : « Foi Vivante », n° 43, 1967
No full textKoch G. Karl Barth, La prière d'après les catéchismes de la Réformation. 3e édition. Collection : « Foi Vivante », n° 52. 1967 L.-J. Lebret, Appels au Seigneur. Collection : « Foi Vivante », n° 43, 1967. In: Revue d'histoire et de philosophie religieuses, 51e année n°1,1971. p. 120
Yves Congar, Cette église que j'aime. Collection : « Foi vivante », n° 70. Paris, Les éditions du Cerf, 1968. Yves Congar, A mes frères. Collection : « Foi vivante », n° 71, 1968
No full textKoch G. Yves Congar, Cette église que j'aime. Collection : « Foi vivante », n° 70. Paris, Les éditions du Cerf, 1968. Yves Congar, A mes frères. Collection : « Foi vivante », n° 71, 1968. In: Revue d'histoire et de philosophie religieuses, 50e année n°2,1970. pp. 202-203
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