6 research outputs found
Eternal Recurrence: Nietzsche’s Prophecy
No full textThesis (B.A. in in Humanistic Studies, Minor in Philosophy, Minor in Art History)--John Cabot University, Spring 2024.This thesis explores the possibility of a direct and literal interpretation of Friedrich Nietzsche’s teaching on the eternal recurrence of the same. Traditionally, interpretations of the eternal recurrence have been bifurcated: one camp views it as Nietzsche’s most scientific hypothesis, while the other regards it as a philosophical thought experiment questioning the acceptance of life. While the latter interpretation predominates, the former is often deemed incomplete. This study delves into Nietzsche’s writings concerning the eternal recurrence and argues in favour of the literal interpretation. By closely analysing Nietzsche’s texts, it demonstrates that the direct reading of the eternal recurrence is indeed valid, and when contextualised with his broader philosophical framework, it emerges as a coherent perspective. This perspective posits the eternal recurrence as a viewpoint that considers the world as our subjective interpretation of the objective universe, thereby bridging Nietzsche’s scientific and philosophical views
Eternal Recurrence: Nietzsche's Prophecy
No full textThesis (B.A. in in Humanistic Studies, Minor in Philosophy, Minor in Art History)--John Cabot University, Spring 2024.This thesis explores the possibility of a direct and literal interpretation of Friedrich Nietzsche’s teaching on the eternal recurrence of the same. Traditionally, interpretations of the eternal recurrence have been bifurcated: one camp views it as Nietzsche’s most scientific hypothesis, while the other regards it as a philosophical thought experiment questioning the acceptance of life. While the latter interpretation predominates, the former is often deemed incomplete. This study delves into Nietzsche’s writings concerning the eternal recurrence and argues in favour of the literal interpretation. By closely analysing Nietzsche’s texts, it demonstrates that the direct reading of the eternal recurrence is indeed valid, and when contextualised with his broader philosophical framework, it emerges as a coherent perspective. This perspective posits the eternal recurrence as a viewpoint that considers the world as our subjective interpretation of the objective universe, thereby bridging Nietzsche’s scientific and philosophical views
Low-Temperature Effects on the Growth and Phytochemical Properties of Wheat Sprouts
No full textSprouting is associated with nutritional value, as microgreens stimulate the accumulation of health-promoting phytochemicals. The purpose of this study was to examine the growth rates and cell protection activity against oxidative stress in sprouts of seven wheat varieties, and to investigate the influence of low temperatures on their phytochemical characteristics. Among the seven wheat varieties (five Korean varieties, Australian standard white, and Chinese wild-type wheat germplasm), purple wheat (Ariheuk) had the fastest growth pattern for 8 days and provided the most protection to skin cells and hepatocytes against oxidative stress. Following low-temperature treatment (<4 °C) for 1–4 days, cold exposure had a similar effect on the growth of purple wheat sprouts during an 8-day period. However, growth was negatively affected by exposure to low temperatures for more than 5 days. Purple wheat sprouts treated with low temperatures for 4 days had considerably higher total polyphenol and total flavonoid contents, as well as a higher antioxidant capacity than untreated wheat sprouts. These findings suggest that low-temperature treatment promotes the expression of phytochemicals in purple wheat sprouts. Thus, purple wheat sprouts are considered a high-value crop that could be used as a functional food material
Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury
No full textAcute respiratory distress syndrome (ARDS) is associated with significant morbidity and mortality, and neutrophils are critical to its pathogenesis. Neutrophil activation is closely regulated by inhibitory tyrosine phosphatases including Src homology region 2 domain–containing phosphatase-1 (Shp1). Here, we report that loss of neutrophil Shp1 in mice produced hyperinflammation and lethal pulmonary hemorrhage in sterile inflammation and pathogen-induced models of acute lung injury (ALI) through a Syk kinase–dependent mechanism. We observed large intravascular neutrophil clusters, perivascular inflammation, and excessive neutrophil extracellular traps in neutrophil-specific Shp1-KO mice, suggesting an underlying mechanism for the observed pulmonary hemorrhage. Targeted immunomodulation through the administration of a Shp1 activator (SC43) reduced agonist-induced reactive oxygen species in vitro and ameliorated ALI-induced alveolar neutrophilia and NETs in vivo. We propose that the pharmacologic activation of Shp1 has the potential to fine tune neutrophil hyperinflammation that is central to the pathogenesis of ARDS.</p
