219 research outputs found
EndoNet: an information resource about endocrine networks
No full textEndoNet is a new database that provides information about the components of endocrine networks and their relations. It focuses on the endocrine cell-to-cell communication and enables the analysis of intercellular regulatory pathways in humans. In the EndoNet data model, two classes of components span a bipartite directed graph. One class represents the hormones ( in the broadest sense) secreted by defined donor cells. The other class consists of the acceptor or target cells expressing the corresponding hormone receptors. The identity and anatomical environment of cell types, tissues and organs is defined through references to the CYTOMER (R) ontology. With the EndoNet user interface, it is possible to query the database for hormones, receptors or tissues and to combine several items from different search rounds in one complex result set, from which a network can be reconstructed and visualized. For each entity, a detailed characteristics page is available. Some well-established endocrine pathways are offered as showcases in the form of predefined result sets. These sets can be used as a starting point for a more complex query or for obtaining a quick overview. The EndoNet database is accessible at http://endonet.bioinf.med.uni-goettingen.de/
XML schemas for common bioinformatic data types and their application in workflow systems
No full textSeibel PN, Krüger J, Hartmeier S, et al. XML schemas for common bioinformatic data types and their application in workflow systems. BMC Bioinformatics. 2006;7(1): 490.Background: Today, there is a growing need in bioinformatics to combine available software tools into chains, thus building complex applications from existing single-task tools. To create such workflows, the tools involved have to be able to work with each other's data – therefore, a common set of well-defined data formats is needed. Unfortunately, current bioinformatic tools use a great variety of heterogeneous formats. Results: Acknowledging the need for common formats, the Helmholtz Open BioInformatics Technology network (HOBIT) identified several basic data types used in bioinformatics and developed appropriate format descriptions, formally defined by XML schemas, and incorporated them in a Java library (BioDOM). These schemas currently cover sequence, sequence alignment, RNA secondary structure and RNA secondary structure alignment formats in a form that is independent of any specific program, thus enabling seamless interoperation of different tools. All XML formats are available at http://bioschemas.sourceforge.net, the BioDOM library can be obtained at http://biodom.sourceforge.net. Conclusion: The HOBIT XML schemas and the BioDOM library simplify adding XML support to newly created and existing bioinformatic tools, enabling these tools to interoperate seamlessly in workflow scenarios
Fiktion und Fakten am Beispiel Carmen Elisabeth Puchianus Prosaband "Amsel – schwarzer Vogel"
No full textLiterary productions live in a multi-dimensional context. On the one hand, the author and his/her reality play a significant role in the creation of the text; on the other hand, the reference to reality takes place through reception, that is, in a dimension where the author and the text are powerless. I would like to research on Carmen Elisabeth Puchianu’s stories Amsel–schwarzer Vogel (München 1995) from this point of view, as some texts have triggered outrageous reactions. These can be explained to some extent as a confusion between fact and fiction as well as a rejection of new literary discourses both in the German literature in Romania and Romanian literature after the political changes in 1989
Impact of selected probiotic bacteria on juvenile host growth in gnotobiotic mouse model
No full textUniverzita Karlova Farmaceutická fakulta v Hradci Králové Katedra biologických a lékařských věd Studijní obor: Farmacie Autor: Veronika Drgoňová Vedoucí práce: PharmDr. Ondřej Janďourek, Ph.D. Konzultant: Mgr. Martin Schwarzer, Ph.D. Název diplomové práce: Vliv vybraných probiotických bakterií na růst hostitele v gnotobiotickém myším modelu Tato diplomová práce rozšiřuje znalosti o schopnosti bakterie Lactiplantibacillus plantarum WJL podporovat růst gnotobiotického hostitele v modelu chronické podvýživy. Bylo zkoumáno, zda i další bakterie mají podobné schopnosti a zda jsou tyto vlastnosti druhově a kmenově specifické. Testovány byly kmeny Bifidobacterium longum ssp. longum a Bifidobacterium adolescentis v gnotobiotickém juvenilním myším modelu chronické podvýživy a byl sledován jejich vliv na somatotropní osu hostitele. Současně bylo analyzováno, jak podvýživa ovlivňuje bakterie ve střevě hostitele a úroveň kolonizace střeva. Bezmikrobní myši C57BL/6J byly monokolonizovány intragastrickou sondou testovanými bakteriálními kmeny. Po ověření stabilní kolonizace byly myši připuštěny a samčí potomci F1 byli převedeni 21. den po narození na experimentální dietu s nízkým obsahem bílkovin a tuků. Každý týden byl sledován jejich růst měřením délky těla a hmotnosti. Myši byly utraceny po 5 týdnech a byly...Charles University Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Study program: Pharmacy Author: Veronika Drgoňová Supervisor: PharmDr. Ondřej Janďourek, Ph.D. Consultant: Mgr. Martin Schwarzer, Ph.D. Title of diploma: Impact of selected probiotic bacteria on juvenile host growth in gnotobiotic mouse model This thesis expands understanding of the ability of Lactiplantibacillus plantarum WJL bacteria to support the growth of gnotobiotic hosts in models of chronic malnutrition. It was investigated whether other bacteria also have similar capabilities and whether these traits are species- and strain-specific. Strains of Bifidobacterium longum ssp. longum and Bifidobacterium adolescentis were tested in a gnotobiotic juvenile mouse model of chronic malnutrition and their impact on the host's somatotropic axis was monitored. Concurrently, it was analysed how malnutrition affects the bacteria in the host's gut and the level of its colonization. Germ-free C57BL/6J mice were mono-colonized via intragastric gavage with the aforementioned bacterial strains. The mice were mated after confirming stable colonization and F1 male offspring were weaned on the 21st day after birth onto an experimental diet with low protein and fat content. Their growth was monitored weekly by...Department of Biological and Medical SciencesKatedra biologických a lékařských vědFarmaceutická fakulta v Hradci KrálovéFaculty of Pharmacy in Hradec Králov
TRANSPATH (R): an information resource for storing and visualizing signaling pathways and their pathological aberrations
No full textTRANSPATH (R) is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. The representation of signaling molecules is organized in a number of orthogonal hierarchies reflecting the classification of the molecules, their species-specific or generic features, and their post-translational modifications. Reactions are similarly hierarchically organized in a three-layer architecture, differentiating between reactions that are evidenced by individual publications, generalizations of these reactions to construct species-independent 'reference pathways' and the 'semantic projections' of these pathways. A number of search and browse options allow easy access to the database contents, which can be visualized with the tool PathwayBuilder (TM). The module PathoSign adds data about pathologically relevant mutations in signaling components, including their genotypes and phenotypes. TRANSPATH (R) and PathoSign can be used as encyclopaedia, in the educational process, for vizualization and modeling of signal transduction networks and for the analysis of gene expression data. TRANSPATH (R) Public 6.0 is freely accessible for users from non-profit organizations under http://www.gene-regulation.com/pub/databases.html
"The EU in the Economic and Social Arrangements of the United Nations System"
No full textThe article deals with the role of the EU in the Economic and Social arrangements of the United Nations system. Looking at the main UN organisations in the area of economic and social affairs concerned with development and humanitarian problems, the author identifies the relation of the EU and its member states to these bodies as a much neglected dimension of Europe’s external relations. He suggests a research agenda for exploring the changing pattern in the multilateral relationships in a range of the economic and social organisations of the United Nations. This, he argues, would move into new territory on relations between regional and global international institutions. In this context, the symbiotic relationship between regionalisation and globalisation could be spelled out in unusually specific terms
Whole Language in a Foreign Language Class: From Theory to Practice
No full textTheoretical perspectives from related disciplines such as early childhood education, bilingual education, and English as a second language education can be valuable in a foreign language education context. This article presents eight philosophical principles needed for implementing a whole language philosophy in a foreign language class and a description of the author\u27s whole language foreign language class (WLFLC) as a practical example. The article outlines the three basic components needed to establish a WLFLC: (1) the classroom setting; (2) the resource books used in the class; and (3) the schedule of instructional activities for the class. The author also presents a description of four major activities used in this WLFLC: (1) language projects; (2) reading children\u27s literature in the foreign language; (3) dialogue journal writing; and (4) portfolio assessment. General conclusions about implementing a whole language philosophy in a foreign language class are provided
- …
