1,609 research outputs found
Command the Air and Command the Market : The Story of KVOS v. the Associated Press (1936)
No full textDr. Helen J. Knowles (recipient of the 2020 Scott Regional Research Fellowship) presents on research on Pacific Northwest broadcasting pioneer Rogan Jones, and the landmark case of KVOS v. Associated Press (1936)
Interview with Chris Koch by Helen Tiffin, 25 Sep 1983
No full textHelen Tiffin interviews Tasmanian author Chris Koch about his work
Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF
No full textHypoxia is an important regulator of bone biology and stimulates osteoclast differentiation from monocytic precursors. Hypoxia-inducible factor (HIF) is a key pro-tumourigenic transcription factor mediating pathways of hypoxia-inducible gene expression. We have described expression of HIF-1α and HIF-2α in the multi-nucleated, osteoclast-like giant cells and the mononuclear stromal component of giant cell tumour of bone (GCTB), a locally osteolytic primary bone tumour. HIF induction was observed in culture in the osteoblastic MG-63 cell line, primary GCTB stromal cells, and monocyte-derived osteoclasts following stimulation with hypoxia (0.1% O2) or the osteoclastogenic cytokines hepatocyte growth factor (HGF) and macrophage colony-stimulating factor (M-CSF). This was accompanied by increased expression of the downstream target genes Bcl-2/adenovirus E1B 19 kD-interacting protein 3 (BNIP3), Glut-1, and vascular endothelial growth factor (VEGF). As VEGF can substitute for M-CSF to support osteoclastogenesis in the presence of receptor activator for nuclear factor κB ligand (RANKL), we assessed the effect of MG-63 hypoxic conditioned media on osteoclast differentiation. In the presence of RANKL, hypoxic conditioned media induced the formation of active osteoclasts, as assessed from the numbers of TRAP-positive multi-nucleated cells and the area of lacunar bone resorption, which was inhibited by co-incubation with a neutralizing anti-VEGF antibody. Targeted siRNA ablated HIF-1α and/or HIF-2α expression in MG-63 cells and reduced hypoxic secretion of VEGF. Hypoxic conditioned media from cells treated with siRNA for (HIF-1α + HIF-2α) produced a significant decrease in osteoclast number (p < 0.005) and activity (p < 0.05) in comparison with the scrambled siRNA control. These results suggest that local hypoxia could indirectly influence osteoclastogenesis via autocrine and paracrine secretion of VEGF under the control of HIF. This is potentially an important mechanism of pathogenesis for GCTB and other osteolytic lesions
Mary Helen McSweeney-Feld, PhD, Long-Term Care Educator and Author
No full textToday’s guest is Mary Helen McSweeney-Feld. Mary Helen is an associate professor at Towson University in the Department of Health Sciences. Mary Helen is the author of one of the leading textbooks in the field of long-term care, Dimensions of Long-Term Care: An Introduction, and is a recognized leader in long-term care education nationally. In this podcast I talk with Mary Helen about her journey from an early interest in political science and international affairs to discovering the nascent field of health economics in the 80’s, and her transition to an interest in long-term care as a result of having to care for both her father and father-in-law when they suffered from debilitating terminal illnesses. Mary Helen makes a passionate case for long-term care, pointing out the economic opportunities for entrepreneurs, as well as young people looking for a meaningful and well compensated career. I hope you enjoy listening to Mary Helen’s story, and if you find it valuable, won’t you leave us feedback on iTunes, Stitcher, Spotify, or wherever you may be accessing this recording. It helps other people discover us. Thanks for listening, and here is Mary Helen McSweeney-Feld
Helen Papanikolas
No full textBlack and white photograph of Helen Papanikolas, author of "The Peoples of Utah.
Making use of historical case material – the problems of looking back and the implications for service development in relation to research and evaluation activities
No full textThis methodological paper details the process of embarking on a follow-up study of young people with sexual behaviour problems who were known to services in the 1990s and who are now young adults in their twenties or early thirties. In the context of the importance of such follow-up work, the overall aim and objectives of the funded research project are specified and the challenges presented in setting up research partnerships with service sites, including the negotiation of access and ethical approval, are the subject of overview and reflection. The practicalities of beginning the fieldwork which comprised an initial analysis of historical case material held in the research sites are then detailed and the solutions to the problems encountered are explained. The article concludes by identifying the kinds of questions services and researchers need to consider when wanting to engender or enhance a research culture which is facilitative of this kind of outcome research. These relate to the resources necessary to support a research culture, the requirements of data protection and ethical approval processes, obtaining service user consent to participate in future research, secure but accessible storage of records, staff development and researchers’ obligations to minimise disruption to already hard pressed services
The Social Construction of the Child Sex Offender Explored by Narrative
No full textThe notion of "child sex offender" provokes aversion, but it may be that it is a social construction. We suggest that a Dominant narrative, in which child sex offenders are constructed as irredeemable, persists, despite the emergence of assumption challenging Alternative narratives. A story completion method was used to elicit themes of Dominant or Alternative narratives, theory-led thematic analysis was used to identify them. The use and analysis of narrative and free-form stories are well established in social research, but remain a novel concept in the study of offenders. The results support the persistence of the Dominant narrative with two notable exceptions. Conclusions centre on utility of the narrative method to examine offender constructions, and the pervasiveness of Dominant narratives. Key Words: Dominant and Alternative Narrative, Social Construction, Child Sex Offenders, and Thematic Analysi
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