6,891 research outputs found
Acid-mediated topological control in a functionalized foldamer
No full textInduced conformational change provides a powerful mechanism to modulate the structure and function of molecules. Here we describe the synthesis of chiral, surface-functionalized oligomeric pyridine/imidazolidin-2-one foldamers, and interrogate their acid-mediated transition between linear and helical topologies
Ion-mediated conformational switches
No full textMolecular switches are ubiquitous in Nature and provide the basis of many forms of transport and signalling. Single synthetic molecules that change conformation, and thus function, reversibly in a stimulus-dependent manner are of great interest not only to chemists but society in general; myriad applications exist in storage, display, sensing and medicine. Here we describe recent developments in the area of ion-mediated switching
Hybrid diphenylalkyne-dipeptide oligomers induce multistrand B-sheet formation
No full textFunctionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multistrand ?-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein–protein interactions
The Peter Martyr reader
No full textAccession Number: ATLA0001328116; Language(s): English; Issued by ATLA: 20080715; Publication Type: Review; Related Books/Electronic Resources: By: Vermigli, Pietro Martire, 1499-1562 Peter Martyr reader viii, 260 p. Publisher: Kirksville, Mo.: Truman State University Press, 1999. ATLA0001327874Source type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=reh&AN=ATLA0001328116&loginpage=Login.asp&site=ehost-liv
A modular synthesis of conformationally preorganised extended β-strand peptidomimetics
Full text linkA promising strategy for mediating protein-protein interactions is the use of non-peptidic mimics of secondary structural protein elements, such as the α-helix. Recent work has expanded the scope of this approach by providing proof-of-principle scaffolds that are conformationally biased to mimic the projection of side-chains from one face of another common secondary structural element-the β-strand. Herein, we present a synthetic route that has key advantages over previous work: monomers bearing an amino acid side-chain were pre-formed before rapid assembly to peptidomimetics through a modular, iterative strategy. The resultant oligomers of alternating pyridyl and six-membered cyclic ureas accurately reproduce a recognition domain of several amino acid residues of a β-strand, demonstrated herein by mimicry of the i, i+2, i+4 and i+6 residues
Cover picture: a modular synthesis of conformationally preorganised extended B-strand peptidomimetics (Chem. Eur.J. 42/2015)
No full textRedox-Dependent Conformational Switching of Diphenylacetylenes
Full text linkHerein we describe the design and synthesis of a redox-dependent single-molecule switch. Appending a ferrocene unit to a diphenylacetylene scaffold gives a redox-sensitive handle, which undergoes reversible one-electron oxidation, as demonstrated by cyclic voltammetry analysis. 1H-NMR spectroscopy of the partially oxidized switch and control compounds suggests that oxidation to the ferrocenium cation induces a change in hydrogen bonding interactions that results in a conformational switch
Remote conformational control of a molecular switch via methylation and deprotonation
No full textExacting control over conformation in response to an external stimulus is the central focus of molecular switching. Here we describe the synthesis of a series of diphenylacetylene-based molecular switches, and examine their response to covalent modification and deprotonation at remote phenolic positions. A complex interplay between multiple intramolecular hydrogen bond donors and acceptors determines the global conformation
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