2,049 research outputs found
S.R. Lewis letter to Z. Eastman, March 5, 1874
No full textBrief letter from S.R. Lewis to Z. Eastman, marking the announcement of an abolitionists' reunion to be held in Chicago in June of 1875. Lewis requests that Eastman, given his close acquaintance with Benjamin Lundy, prepare a public statement of remembrance on Lundy and his contributions to the anti-slavery movement. Benjamin Lundy (1789-1839) was a prominent Quaker abolitionist best known for his development of abolitionist periodicals. His Genius of Universal Emancipation was first published in 1821 from his home in Mt. Pleasant, Ohio, and enjoyed a wide circulation across the antebellum United States. In the 1820s, the young William Lloyd Garrison came to work for The Genius. Benjamin Lundy traveled widely seeking subscriptions to The Genius, giving talks about the anti-slavery movement, and observing and documenting the conditions of enslaved people across the Americas. He was also involved in the establishment of freed slave colonies in Mexico
Modelling and optimization of a permanent-magnet machine in a flywheel
No full textThis thesis describes the derivation of an analytical model for the design and optimization of a permanent-magnet machine for use in an energy storage flywheel. A prototype of this flywheel is to be used as the peak-power unit in a hybrid electric city bus. The thesis starts by showing the feasibility of using a flywheel energy storage system for this application, as opposed to other energy storage technologies. It then continues by describing a prototype flywheel system and the required electrical machine: a radial-flux external-rotor permanent-magnet synchronous machine without slots in the stator iron and with a shielding cylinder. An analytical model for the machine is derived, based on 2D electromagnetic field calculations, including the reaction field of the eddy currents in the shielding cylinder. Torque and losses are calculated by means of the Theorem of Poynting and the Lorentz force. Such a machine was built and the analytical model has been validated by experimental measurements. Lastly, the thesis suggests and implements a machine optimization algorithm.Information Technology and System
Design metrics for evaluating the propulsive efficiency of future ships
No full textThere is an increasing need for the ship design process to take account of environmental issues such as the emission of greenhouse gases and the likely extension of a carbon dioxide charging mechanism to international shipping. These issues, together with the need for economic viability, provide further incentives to improve the efficiency of propulsion of ships. The main components of powering are firstly reviewed. Individual components and other power saving devices are identified which should contribute to improvements in the overall efficiency of propulsion. Suitable design metrics and procedures, taking into account economic and environmental factors, are recommended for the design of future ships
Description of S.R. Krom's system and machinery for dry crushing and concentrating ores.
No full textCover title.Mode of access: Internet.MAIN; TN500.K7 1876: Introduction signed by author, S.R. Krom
The primary cilium orchestrates chondrocyte mechanotransduction
No full textPurpose: to understand the role of the chondrocyte primary cilium in mechanotransduction. The primary cilium is a singular organelle protruding outward from the mature centriole into the extracellular space, decorated with many receptors and integrins. The tubulin scaffold, ciliary membrane and proteome are constructed and maintained by dynein motors and intraflagellar transport cargos. In many cell types such as kidney epithelia, vascular endothelium and osteocytes, primary cilia are involved in mechanotransduction, often through the activities of polycystin 1 and 2 located on the cilium. Physiologically cartilage experiences mechanical signals, altering cell behaviour, that include compression and fluid flow. It is thought aberrant mechanotransduction may be one factor in the development of tissue pathology. Here we test the hypothesis that the cilium is essential for chondrocyte mechanotransduction and the up-regulation of proteoglycan synthesis through an established purinergic pathway involving the release of ATP and subsequent activation of Ca2+ signalling.Methods: to test this we used a hypomorphic mutation of Tg737, which encodes for IFT88, and abolishes genesis and growth of the cilium and which has been shown in vivo to result in murine matrix patterning defects. A well-established 3D agarose culture system was implemented to allow compressive loading of murine WT and Tg737 chondrocytes in culture followed by the quantification of ATP release with a luciferase assay, calcium transients by means of Fluo-4 imaging, and matrix production by qPCR and biochemical assay. Additionally expression of purinergic receptors (P2R) and polycystins (PC) 1 and 2 were assessed by western blot and immunocytochemistry.Results: compression of WT chondrocytes increased calcium transients (p<0.05) and matrix production at gene and protein levels (p<0.05) however these mechanosensitive responses were not present in Tg737 chondrocytes. Mechanosensitive ATP release (p<0.01) was maintained between WT and Tg737 cells implying that the cilium is required for ATP reception or transduction. Indeed, exogenous addition of ATP up-regulated Ca2+ transients in WT (p<0.001) but did not in Tg737 cells, although there were no differences in P2R expression. In Tg737 cells PC-1 expression was altered such that the full size protein product was absent.Conclusions: we conclude that the primary cilium is essential for chondrocyte mechanotransduction through the regulation of purinergic Ca2+ signalling. We speculate that this may be attributed to a role for the cilia protein polycystin-1. This demonstrates the central role for the chondrocyte primary cilium in cartilage physiology in the context of the chondrocyte response to mechanical stimuli
Matthew S.R. Palmer & Dean R. Knight. The Constitution of New Zealand: A Contextual Analysis [Book Review]
No full textKnight and Palmer’s The Constitution of New Zealand: A Contextual Analysis provides an excellent overview of New Zealand’s Constitution today. This review explains why. It then critically examines how the authors address te Tiriti o Waitangi, tino rangatiratanga, and Māori rights more broadly, including under international law
Defining standards and core outcomes for clinical trials in prehabilitation for colorectal surgery (DiSCO): modified Delphi methodology to achieve patient and health-care professional consensus
No full text
Refinement of solutions to the linear complimentarity problem
No full textNash equilibrium;game theaory;matrices
Toward more efficient heuristic construction of Boolean functions
No full textBoolean functions have numerous applications in domains as diverse as coding theory, cryptography,and telecommunications. Heuristics play an important role in the construction of Boolean functions with the desired properties for a specific purpose. However, there are only sparse results trying to understand the problem’s difficulty. With this work, we aim to address this issue. We conduct a fitness landscape analysis based on Local Optima Networks (LONs) and investigate the influence of different optimization criteria and variation operators. We observe that the naive fitness formulation results in the largest networks of local optima with disconnected components. Also, the combination of variation operators can both increase or decrease the network size. Most importantly, we observe correlations of local optima’s fitness, their degrees of interconnection, and the sizes of the respective basins of attraction. This can be exploited to restart algorithms dynamically and influence the degree of perturbation of the current best solution when restarting.Domagoj Jakobovic, Stjepan Picek, Marcella S.R. Martins, Markus Wagne
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