58,562 research outputs found
Drawing and writing on the screen
No full textThis chapter focuses on the physicality of the iPad as an object, and how that physicality affects the interactions children have with the device generally, and the apps specifically. Thinking about the physicality of the iPad is important because the materials, size, weight and appearance make the iPad quite unlike most other toys and equipment in the kindergarten space. Most strikingly, this physicality does not ‘represent’ the virtual vast dimensions of the iPad brought about through the diverse functions and contents of the apps contained in it. While the iPad is small enough and functional enough to be easily handled and operated even by young children, it is capable of performing highly complex, highly technological tasks that take it beyond its diminutive dimensions. \ud
This virtual-actual contrast is interesting to consider in relation to the other resources more commonly found in a kindergarten space. While objects such as toys, bricks, building materials often do prompt the child to imagine and invent beyond the physical boundaries of the toy, they not have the same types of virtual-actual contrasts of a digital device such as the iPad. \ud
\ud
How then, might children be drawn to the iPad because of its physical, technological and virtual difference? \ud
Particularly, how might this virtual-actual difference impact on the physical skills associated with writing and drawing: skills usually learnt through the use of a pencil and paper? While the research project did not set out to compare how digital and paper-based resources affect writing and drawing skills there was great interest to see how young children negotiated drawing and writing on the shiny glass surface of the iPad
$150.00 REWARD On Monday morning, April 21, 1892 Grover Orvis shot and killed Jacob Knight
No full text$150.00 REWARD
On Monday morning, April 21, 1892 Grover Orvis shot and killed Jacob Knight, an Indian preacher, near McDermott. The above reward will be paid for the capture of Grover Orvis and his father, C. M. Orvis.
Grover Orvis is about five feet eight inches, weighs about140lbs, smooth face. light complexion,
blue eyes, age about 21 years. C. M. Orvis is about five feet 10 inches, about 55 years old, light
complexion, heavy gray mustache, blue eyes, very slim face, weight
about 180 pounds. For further information or particulars,
Address:
F. M. RILEY,
McDermott, I. T.
April 25, 1902
Chlamydatus ruficornis Knight 1959
No full textChlamydatus ruficornis Knight, 1959: 424 (n.sp.). DIAGNOSIS: Distinguished from all other Chlamydatus spp. by the following combination of characters: the slate gray coloration, the red appendages, the fusiform antennal segment 2, the frequent brachyptery (fig. 2) with the males rarely being macropterous, and the entirely dull vertex and face. HOSTS: None recorded. DISTRIBUTION: Plains region of North America. DISCUSSION: Knight (1959) and Kelton (1965) treated C. ruficornis as always brachypterous with truncate hemelytra. We have examined a male specimen from Colorado that is fully macropterous (fig. 2); it was taken with a series of brachypterous females on prostrate vegetation in a waste area. Macropterous males are now known from Alberta. SPECIMENS EXAMINED: Holotype: male: ‘‘ Ames, Iowa, VII221940, H. H. Knight’ ’; deposited in the National Museum of Natural History, Washington, D.C. Additional specimens: CANADA: Alberta: Irvine, May 23, 1952, A. R. Brooks, 13 (CNC). Saskatchewan: Saskatchewan Landing, June 22, 1982, G. G. E. Scudder, 2♀ (UBC). Val Marie, May 11, 1965, A. R. Brooks, 13 (CNC). USA: Colorado: Albert Co.: E of Kiowa on Rt 86, West Bijou Creek, 1810 m, May 20, 1978, R. T. Schuh and J. T. Polhemus, 83, 19♀ (AMNH). Iowa: Story Co.: Ames, July 22, 1930, H. H. Knight, paratypes, 23, 1♀ (CNC, USNM). New Mexico: Torrance Co.: Estancia, June 24, 1940, D. E. Hardy, 13 (KU).Published as part of SCHUH, RANDALL T. & SCHWARTZ, MICHAEL D., 2005, Review of North American Chlamydatus Curtis Species, with New Synonymy and the Description of Two New Species (Heteroptera: Miridae: Phylinae), pp. 1-56 in American Museum Novitates 3471 (1) on page 48, DOI: 10.1206/0003-0082(2005)4712.0.CO;2, http://zenodo.org/record/538303
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response
No full textPrimary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate cilia function, governed in part by the activity of intraflagellar transport (IFT). In articular cartilage, primary cilia length is increased and hedgehog signaling activated in osteoarthritis (OA). Here, we examine primary cilia length with exposure to the quintessential inflammatory cytokine interleukin-1 (IL-1), which is up-regulated in OA. We then test the hypothesis that the cilium is involved in mediating the downstream inflammatory response. Primary chondrocytes treated with IL-1 exhibited a 50 % increase in cilia length after 3 h exposure. IL-1-induced cilia elongation was also observed in human fibroblasts. In chondrocytes, this elongation occurred via a protein kinase A (PKA)-dependent mechanism. G-protein coupled adenylate cyclase also regulated the length of chondrocyte primary cilia but not downstream of IL-1. Chondrocytes treated with IL-1 exhibit a characteristic increase in the release of the inflammatory chemokines, nitric oxide and prostaglandin E2. However, in cells with a mutation in IFT88 whereby the cilia structure is lost, this response to IL-1 was significantly attenuated and, in the case of nitric oxide, completely abolished. Inhibition of IL-1-induced cilia elongation by PKA inhibition also attenuated the chemokine response. These results suggest that cilia assembly regulates the response to inflammatory cytokines. Therefore, the cilia proteome may provide a novel therapeutic target for the treatment of inflammatory pathologies, including OA
The archaeoacoustics of San Vitale, Ravenna
No full textThis research tests and assesses whether sixth-century social and cultural dynamics can be archaeologically identified by including the study of acoustics in the context of extant Late Antique Christian architecture, namely the centrally planned domed octagonal church of San Vitale at Ravenna. Implementing a holistic archaeological research strategy that includes human sensory perception of acoustical phenomena is the best approach to unravelling the complexities of social and cultural mechanisms operating in the sixth-century Mediterranean basin. The methods and issues of Archaeoacoustics are critiqued and developed in order to comment on the intentionality of acoustic attributes in sixth-century ecclesiastical architecture.The space syntax of San Vitale has been considered for isovists at key locations during the liturgical procession and sequence of the Mass celebration. These are compared with mapped areas of perceiving the acoustic characteristics of Clarity and Reverberation Time. Combining the visual and acoustic analysis of San Vitale, with a better understanding of its date and construction phases, the physical geometry and temporal logic of the church are discussed in relation to the reflexive exchange of influence between Ravenna, Milan and Constantinople. It is posited that liturgical and musical time and tempo is materially expressed in the evident and conceptual substance of San Vitale, a suggestion that offers a springboard for future study and debate
Settling of finite-size particles in isotropically forced, homogeneous turbulence: interface-resolved simulations
No full textWe have simulated the gravity-induced settling of finite-size particles in a turbulent background flow which is forced in a statistically-stationary fashion. The simulations are accurately resolving the solid-fluid interface with the aid of an immersed boundary technique [1]. The parameters of the simulation are (apart from background turbulence) identical to those of reference [2], where particle clustering was observed at a Galileo number of 178 and a solid volume fraction of 0.005. In the present case, it is found that a relative turbulence intensity of 0.24 leads to the disappearance of the clusters; as a consequence, the increase in average particle settling velocity found in [2] also vanishes. [1] M. Uhlmann. An immersed boundary method with direct forcing for the simulation of particulate flows. J. Comput. Phys., 209(2):448–476, 2005. [2] M. Uhlmann and T. Doychev. Sedimentation of a dilute suspension of rigid spheres at intermediate Galileo numbers: the effect of clustering upon the particle motion. J. Fluid Mech., 752:310–348, 2014
Quantitative assessment of apoptosis in specific cell types in isolated perfused hearts exposed to ischemia and reperfusion
No full textMesophilic-hydrothermal-thermophilic (M-H-T) digestion of green corn straw
No full textMesophilic-hydrothermal (80-160 degrees C, 30 min)-thermophilic (M-H-T) digestion and control tests of mesophilic (M), thermophilic (T), hydrothermal-mesophilic (H-M), and mesophilic-thermophilic digestion (M-T) of green corn straw were conducted for a 20-day fermentation period. The results indicate that M-H-T is an efficient method to improve methane production. A maximum methane yield of 371.74 mL/g volatile solid was obtained by the M (3 days)-H (140 degrees C)-T (17 days) process, which was 20.44%, 16.55%, 31.44%, and 14.31% higher than the yields of the M, T, 140-M, and M-T processes. The enhanced methane production was attributed to (1) the improved hemicellulose degradation and lignin disorganization; (2) prevention of the degradation of soluble sugar, easily hydrolyzed hemicellulose and cellulose into furfural and methylfurfural; and (3) lack of formation of Maillard reaction products during initial hydrothermal treatment. (C) 2015 Elsevier Ltd. All rights reserved
Viscoelastic Cell Mechanics and actin remodelling are dependent on the rate of applied pressure
No full textBackground: living cells are subjected to external and internal mechanical stresses. The effects of these stresses on the deformation and subsequent biological response of the cells remains unclear. This study tested the hypothesis that the rate at which pressure (or stress) is applied influence the viscoelastic properties of the cell associated with differences in the dynamics of the actin cytoskeleton.Principal finding: micropipette aspiration was used to determine the instantaneous and equilibrium moduli and the viscosity of isolated chondrocytes based on the standard linear solid (SLS) model and a variation of this incorporating Boltzmann superposition. Cells were visualised for 180 seconds following aspiration to 7 cmH2O at 0.35, 0.70 and 5.48 cmH2O/sec. Cell recovery was then examined for a further 180 seconds once the pressure had been removed. Reducing the rate of application of pressure reduced the levels of cell deformation and recovery associated with a significant increase in modulus and viscosity. Using GFP transfection and confocal microscopy, we show that chondrocyte deformation involves distortion, disassembly and subsequent reassembly of the cortical actin cytoskeleton. At faster pressure rates, cell deformation produced an increase in cell volume associated with membrane bleb formation. GFP-actin transfection inhibited the pressure rate dependent variation in cell mechanics indicating that this behaviour is regulated by GFP-sensitive actin dynamics.Conclusion: we suggest that slower rates of aspiration pressure enable greater levels of cortical actin distortion. This is partially inhibited by GFP or faster aspiration rates leading to membrane bleb formation and an increase in cell volume. Thus the rate of application of pressure regulates the viscoelastic mechanical properties of living cells through pressure rate sensitive differences in actin dynamics. Therefore cells appear softer when aspirated at a faster rate in contrast to what is expected of a normal viscoelastic materia
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
- …
