163,581 research outputs found
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Antifaschismus und Widerstand: Spuren in die Gegenwart (Vorwort zu Neuauflage von: Die unterbrochene Spur)
Full text link"... unsere Kameradschaft auf Leben und Tod": Annke-Margarethe Knauer (1901-1987) und Alfred Hein (1894-1945)
No full text"... unsere Kameradschaft auf Leben und Tod" : Annke-Margarethe Knauer (1901- 1987) u. Alfred Hein (1894-1945). - In: Beuthener Geschichts- und Museumsverein: Mitteilungen des ... 48. 1987. S. 111-13
3D Visualization - Using High Resolution Multi.Sensor Data
No full textThis is an approach creating a three dimensional virtual world by using high resolution multi-sensor data. The throne hall of Neuschwanstein castle was visualized three dimensional with the help of multi-sensor data records. The high resolution multi-sensor data was based on laser scanner data and panoramic/matrix camera images. It is illustrated how multi-sensor data can be processed, achieving impressive results. It is also presented the state of the art concerning technologies and software solutions and approaches for future activities
Characterization of cull sows harvested in the U.S.
No full textStalder, K.J.; Knauer, M.; Karriker, L.; Baas, T.J.; Johnson, C.; Serenius, T.; Layman, L.; Mabry, J. W.; McKean, J.D.. (2006). Characterization of cull sows harvested in the U.S.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/157430
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Performance and economic evaluation of feeding cull sows
No full textFitzgerald, R.; Stalder, K.J.; Karriker, L.; Knauer, M.; Johnson, C.; Baas, T.J.; Layman, L.; Mabry, J. W.. (2006). Performance and economic evaluation of feeding cull sows. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/157432
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
Untersuchungen zur Bedeutung des Kern-Zytoplasma Transports für die biologische Funktion zellulärer Proteine
No full textThe thesis entitled „Investigations on the significance of nucleo-cytoplasmic transport for the biological function of cellular proteins" aimed to unreveal molecular mechanisms in order to improve our understanding of the impact of nucleo-cytoplasmic transport on cellular functions. Within the scope of this work, it could be shown that regulated nucleo-cytoplasmic transport of a subfamily of homeobox transcription factors controlled their intra- and intercellular transport, and thereby influencing also their transcriptional activity. This study describes a novel regulatory mechanism, which could in general play an important role for the ordered differentiation of complex organisms. Besides cis-active transport Signals, also post-translational modifications can influence the localization and biological activity of proteins in trans. In addition to the known impact of phosphorylation on the transport and activity of STAT1, experimental evidence was provided demonstrating that acetylation affected the interaction of STAT1 with NF-kB p65, and subsequently modulated the expression of apoptosis-inducing NF-kB target genes. The impact of nucleo-cytoplasmic transport on the regulation of apoptosis was underlined by showing that the evolutionary conservation of a NES within the anti-apoptotic protein survivin plays an essential role for its dual function in the inhibition of apoptosis and ordered cell division. Since survivin is considered a bona fide cancer therapy target, these results strongly encourage future work to identify molecular decoys that specifically inhibit the nuclear export of survivin as novel therapeutics. In order to further dissect the regulation of nuclear transport and to efficiently identify transport inhibitors, cell-based assays are urgently required. Therefore, the cellular assay Systems developed in this work may not only serve to identify synthetic nuclear export and Import inhibitors but may also be applied in systematic RNAi-screening approaches to identify novel components of the transport machinery. In addition, the translocation based protease- and protein-interaction biosensors can be applied in various biological Systems, in particular to identify protein-protein interaction inhibitors of cancer relevant proteins. In summary, this work does not only underline the general significance of nucleo-cytoplasmic transport for cell biology, but also demonstrates its potential for the development of novel therapies against diseases like cancer and viral infections.Die vorliegende Arbeit mit dem Titel „Untersuchungen zur Bedeutung des Kern- Zytoplasma Transports für die biologische Funktion zellulärer Proteine" hatte die Aufklärung molekularer Mechanismen des nukleozytoplasmatischen Transports zum Ziel, um so unser Verständnis von dessen Bedeutung für verschiedene zelluläre Funktionen zu vertiefen. Im Rahmen dieser Arbeit konnte gezeigt werden, daß der regulierte Kern-Zytoplasma Transport einer Unterfamilie der Homeobox Transkriptionsfaktoren deren intra- und interzellulären Transport und letztendlich deren transkriptionelle Aktivität beeinflussen konnte. Diese Studie beschreibt einen neuartigen Regulationsmechanismus, welcher für die geordnete Differenzierung komplexer Organismen eine allgemein wichtige Rolle spielen könnte. Neben cis-aktiven Transportsignalen können auch posttranslationelle Modifikation die Lokalisation und biologische Aktivität von Proteinen in trans beeinflussen. Im Rahmen dieser Arbeit konnte gezeigt werden, daß durch Acetylierung des Transkriptionsfaktors Stat1 dessen Interaktion mit NF-KB p65 verstärkt, und somit die subzelluläre Lokalisation und die DNA-Bindung von NF-KB sowie letztendlich die NF-KB kontrollierte Expression von Apoptose-induzierenden Zielgenen beeinflußt wurde. Des weiteren konnte gezeigt werden, daß die evolutionäre Konservierung eines nuklearen Exportsignals (NES) im anti-apoptotischen Protein Survivin für dessen duale Funktion, der Verhinderung von Apoptose und der geordneten Zellteilung, eine essentielle Rolle spielt. Diese Ergebnisse unterstützen den Ansatz, durch spezifische Inhibierung des Kern-Zytoplasma Transports von krankheitsrelevanten Proteinen neue Therapeutika zu entwickeln. Zur Umsetzung dieses Vorhabens wurden zelluläre Testsysteme entwickelt, welches es erlauben, spezifische Kerntransportinhibitoren zu identifizieren. Das Prinzip der nukleären Translokation konnte darüber hinaus zur Etablierung von Protease und Protein-Interaktions Biosensoren weiterentwickelt werden. Die vorliegende Arbeit unterstreicht nicht nur die allgemeine zellbiologische Bedeutung des nukleozytoplasmatischen Transports, sondern zeigt auch dessen Potential zur Entwicklung neuer Therapien gegen Krankheiten wie Krebs und virale Infektionen
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