102,905 research outputs found
Aventures du docteur Faust, et sa descente aux enfers / [Friedrich Maximilian von Klinger]
No full textAVENTURES DU DOCTEUR FAUST, ET SA DESCENTE AUX ENFERS / [FRIEDRICH MAXIMILIAN VON KLINGER]
Aventures du docteur Faust, et sa descente aux enfers / [Friedrich Maximilian von Klinger]
Aventures du docteur Faust, et sa descente aux enfers / [Friedrich Maximilian von Klinger] ; T. 1 (T. 1) (1)
Aventures du docteur Faust, et sa descente aux enfers / [Friedrich Maximilian von Klinger] ; T. 2 (T. 2) (1
Les Aventures de Faust, Et Sa Descente Aux Enfers / [Friedrich Maximilian von Klinger]. Par MM. De Saur et De Saint-Geniés
No full textLES AVENTURES DE FAUST, ET SA DESCENTE AUX ENFERS / [FRIEDRICH MAXIMILIAN VON KLINGER]. PAR MM. DE SAUR ET DE SAINT-GENIÉS
Les Aventures de Faust, Et Sa Descente Aux Enfers / [Friedrich Maximilian von Klinger]. Par MM. De Saur et De Saint-Geniés
Les Aventures de Faust, Et Sa Descente Aux Enfers / [Friedrich Maximilian von Klinger]. Par MM. De Saur et De Saint-Geniés ; T. 1 (T. 1) (1)
Les Aventures de Faust, Et Sa Descente Aux Enfers / [Friedrich Maximilian von Klinger]. Par MM. De Saur et De Saint-Geniés ; T. 2 (T. 2) (1)
Les Aventures de Faust, Et Sa Descente Aux Enfers / [Friedrich Maximilian von Klinger]. Par MM. De Saur et De Saint-Geniés ; T. 3 (T. 3) (1
Geld oder Leben – Sorge und Sorgearbeit im Kapitalismus
No full textAulenbacher B, Haubner T, Klinger C. Geld oder Leben – Sorge und Sorgearbeit im Kapitalismus. Weinheim: Beltz Juventa; Unpublished
On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line SH-SY5Y
No full textPasdziernik M, Kaltschmidt B, Kaltschmidt C, Klinger C, Kaufmann M. On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line SH-SY5Y. BMC Research Notes. 2009;2(1):102.Background: The human cancer-related nucleoside triphosphatase (HCR-NTPase) is overexpressed in several tumour tissues including neuroblastoma. HCR-NTPase is an enzyme exhibiting a slow in vitro activity in hydrolysing nucleosidetriphosphates. However, its in vivo function is still unknown. To learn more about the physiological role of HCR-NTPase, we both overexpressed and silenced it in the neuroblastoma cell line SH-SY5Y. Findings: No effect was observed when the expression of endogenously expressed HCR-NTPase in the cells was silenced by RNA interference. On the other hand, overexpression of HCR-NTPase led to cytotoxicity of the protein in SH-SY5Y cells. Even if the catalytic essential amino acid glutamate 114 was replaced by alanine (E114A-HCR-NTPase), the protein remained cytotoxic. The results could be confirmed by successfully rescuing the cells via RNA interference. Conclusion: Although expressed in several tumours, at least in SH-SY5Y, HCR-NTPase is not essential for the cells to survive. Increased levels of the protein lead to cytotoxicity due to physical intracellular interactions rather than hydrolysis of nucleosidetriphosphates by its intrinsic residual enzymatic activity
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Intraosseous foreign body granuloma in rotator cuff repair with bioabsorbable suture anchor
No full textBiodegradable implants lead to problems such as cyst formation, soft-tissue inflammation, loose implant fragments or local osteolysis. This report represents the first published case of an intraosseous foreign body granuloma in the humeral head after arthroscopic rotator cuff tear fixation with a poly-l-lactide (PLLA) suture anchor. A 48-year-old female patient presented with pain in her right shoulder. A refixation of her right supraspinatus tendon with a biodegradable suture anchor was performed 11 months ago at an external hospital. Laboratory tests showed normal values for C-reactive protein, leukocytes and the erythrocyte sedimentation rate. No signs of infection or instability were noted. The visual analogue scale (VAS) was 8, the simple shoulder test (SST) was 4 and the American shoulder and elbow surgeons score (ASES) was 44. Plain radiographs showed high lucency in the area of the tuberculum majus. MRI showed an intra- and extraosseous mass surrounded by fluid in this area. Surgical care involved arthroscopic debridement and removal of the suture anchor. Histological examination revealed a foreign body granuloma. At the 18-month follow-up the patient was nearly pain-free. The VAS was 2, SST was 10 and ASES was 88. Foreign body granulomas are a well known but rarely described complication that arises after the use of biodegradable suture anchors in shoulder surgery. Every patient presenting with shoulder pain after usage of a biodegradable fixation material should be evaluated closely. Orthopaedic surgeons should be aware of the possibility of delayed foreign body reactions, especially after using PLLA anchors
Treatment of malunited fractures of the anterior tibial spine
No full textAvulsion fractures of the anterior tibial spine are uncommon injuries, and most often seen in childhood. They can be associated with other intraarticular lesions and have, if adequately treated, a good long-term prognosis. In adults these fractures can be complicated by loss of knee extension because of the displacement of the bony fragment. This is most often as a result of non- or malunion of the displaced fragment. We review two cases of malunited fractures of the anterior tibial spine. Both patients reported persistent knee pain and loss of knee extension, and had had an anterior knee laxity for a long time. They had been treated extensively by physiotherapy. In one patient, arthroscopy in another hospital revealed no reasons for the clinical symptoms. More than twenty years after the initial trauma, both patients visited our hospital. A radiograph and a magnetic resonance imaging were respectively carried out both of which revealed a malunited avulsion fracture. According to the examinations, the patients were treated by open reduction and internal fixation, and in the follow up exploration both no longer had discomfort. Clinical and radiological features of this less common and rarely reported injury are discussed and the surgical treatment is demonstrated
CD304+ adipose tissue-derived mesenchymal stem cell abundance in autologous fat grafts highly correlates with improvement of localized pain syndromes
No full textSurgery, burns or surgery-free accident are leading causes of scars with altered tissue consistency, a reduced degree of motion and pain. Autologous fat grafting can dramatically improve tissue consistency and elasticity but less frequently results in the reduction of pain. Therefore, we analyzed different cell populations present within the adipose tissue to be engrafted and correlated them with the reduction of pain after surgery. Here, we identify a population of CD3(-)CD4(-)CD304(+) cells present in grafted adipose tissue, whose abundance highly correlates with pain improvement shortly after surgery (r(2) = 0.7243****) as well as persistently over time (3 months later: r(2) = 0.6277****, 1 year later: r(2) = 0.5346***, and 4 years later: r(2) = 0.5223***). These cells are characterized by the absence of the hematopoietic marker CD45, whereas they express CD90 and CD34, which characterize mesenchymal stem cells (MSCs); the concomitant presence of CD10 and CD73 in the plasma membrane supports a function of these cells in pain reduction. We deduce that the enrichment of this adipose tissue-derived MSC subset could enhance the therapeutic properties of adipose grafts and ameliorate localized pain syndromes
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