2,423 research outputs found
Temperature physiology of Antarctic invertebrates
No full textSartoris FJ, Krüger O, Klein B. Temperature physiology of Antarctic invertebrates. Reports on Polar and Marine Research. 2001;402:129-131
Increased expression of NR2A subunit does not alter NMDA-evoked responses incultured fetal trisomy 16 mouse hippocampal neurons
No full textThe trisomy 16 (Ts16) mouse is an animal model for human trisomy 21 (Down's syndrome). The gene encoding the NR2A subunit of the NMDA receptor has been localized to mouse chromosome 16. In the present study, western blot analysis revealed a 2.5-fold increase of NR2A expression in cultured Ts16 embryonic hippocampal neurons. However, this increase did not affect the properties of NMDA-evoked currents in response to various modulators. The sensitivity of NMDA receptors to transient applications of NMDA, spermine, and Zn2+ was investigated in murine Ts16 and;control diploid cultured embryonic hippocampal neurons. Peak and steady-state currents evoked by NMDA were potentiated by spermine at concentrations <1 mM, and inhibited by Zn2+ in a dose-dependent and voltage-independent manner. No marked difference was observed between Ts16 and control diploid neurons for any of these modulators with regard to IC50 and EC50 values or voltage dependency. Additionally, inhibition by the NR2B selective inhibitor, ifenprodil, was similar. These results demonstrate that NMDA-evoked currents are not altered in cultured embryonic Ts16 neurons and suggest that Ts16 neurons contain similar functional properties of NMDA receptors as diploid control neurons despite an increased level of NR2A expression
Effect of different sex of tumour bearing mice and of ovariectomy on the proliferation kinetics of a solid, transplantable mammary carcinoma (C3H-mouse)
No full textContractions, deformations and curvature RID F-2453-2010
No full textThe role of curvature in relation with Lie algebra contractions of the pseudo-orthogonal algebras so(p,q) is fully described by considering some associated symmetrical homogeneous spaces of constant curvature within a Cayley-Klein framework. We show that a given Lie algebra contraction can be interpreted geometrically as the zero-curvature limit of some underlying homogeneous space with constant curvature. In particular, we study in detail the contraction process for the three classical Riemannian spaces (spherical, Euclidean, hyperbolic), three non-relativistic (Newtonian) spacetimes and three relativistic ((anti-)de Sitter and Minkowskian) spacetimes. Next, from a different perspective, we make use of quantum deformations of Lie algebras in order to construct a family of spaces of non-constant curvature that can be interpreted as deformations of the above nine spaces. In this framework, the quantum deformation parameter is identified as the parameter that controls the curvature of such "quantum" spaces
On automorphism groups of Riemann double covers of Klein surfaces
No full textIf G is a group of automorphisms of a compact Klein surface X, then the direct product G × C2 is a group of automorphisms of the Riemann double cover X+ of X. In this paper we analyse the relationship between G and the full groups of automorphisms Aut(X) and Aut(X+) of X and X+ respectively, in the special case where the group G is uniformised by a non-Euclidean crystallographic group with quadrangular signature (2, 2, 2, n). There is a difference in what happens between bordered surfaces and unbordered non-orientable surfaces, and so we consider those cases separately (including the special situation for n = 4 in the unbordered case).AM - Accepted Manuscrip
81 fJ/bit energy-to-data ratio of 850 nm vertical-cavity surface-emitting lasers for optical interconnects
No full textThis article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Appl. Phys. Lett. 98, 231106 (2011) and may be found at https://doi.org/10.1063/1.3597799.Extremely energy-efficient oxide-confined high-speed 850 nm vertical-cavity surface-emitting lasers for optical interconnects are presented. Error-free performance at 17 and 25 Gb/s via a 100 m multimode fiber link is demonstrated at record high dissipation-power-efficiencies of up to 69 fJ/bit (<0.1mW/Gbps) and 99 fJ/bit, respectively. These are the most power efficient high-speed directly modulated light sources reported to date. The total energy-to-data ratio is 83 fJ/bit at 25°C and reduces to 81 fJ/bit at 55°C. These results were obtained without adjustment of driving conditions. A high -factor of 12.0GHz/(mA)0.5 and a -factor of 0.41 ns are measured.EC/FP7/224211/EU/VISIT - Vertically Integrated Systems for Information Transfer/VISITDFG, 43659573, SFB 787: Halbleiter - Nanophotonik: Materialien, Modelle, Bauelement
Changes in MEG resting-state networks are related to cognitive decline in type 1 diabetes mellitus patients
No full textOBJECTIVE: Integrity of resting-state functional brain networks (RSNs) is important for proper cognitive functioning. In type 1 diabetes mellitus (T1DM) cognitive decrements are commonly observed, possibly due to alterations in RSNs, which may vary according to microvascular complication status. Thus, we tested the hypothesis that functional connectivity in RSNs differs according to clinical status and correlates with cognition in T1DM patients, using an unbiased approach with high spatio-temporal resolution functional network.; METHODS: Resting-state magnetoencephalographic (MEG) data for T1DM patients with (n=42) and without (n=41) microvascular complications and 33 healthy participants were recorded. MEG time-series at source level were reconstructed using a recently developed atlas-based beamformer. Functional connectivity within classical frequency bands, estimated by the phase lag index (PLI), was calculated within eight commonly found RSNs. Neuropsychological tests were used to assess cognitive performance, and the relation with RSNs was evaluated.; RESULTS: Significant differences in terms of RSN functional connectivity between the three groups were observed in the lower alpha band, in the default-mode (DMN), executive control (ECN) and sensorimotor (SMN) RSNs. T1DM patients with microvascular complications showed the weakest functional connectivity in these networks relative to the other groups. For DMN, functional connectivity was higher in patients without microangiopathy relative to controls (all p<0.05). General cognitive performance for both patient groups was worse compared with healthy controls. Lower DMN alpha band functional connectivity correlated with poorer general cognitive ability in patients with microvascular complications.; DISCUSSION: Altered RSN functional connectivity was found in T1DM patients depending on clinical status. Lower DMN functional connectivity was related to poorer cognitive functioning. These results indicate that functional connectivity may play a key role in T1DM-related cognitive dysfunction
Single-drive high-speed lumped depletion-type modulators toward 10 fJ/bit energy consumption
No full textReduction of modulator energy consumption to 10 fJ/bit is essential for the sustainable development of communication systems. Lumped modulators might be a viable solution if instructed by a complete theory system. Here, we present a complete analytical electro-optic response theory, energy consumption analysis, and eye diagrams on absolute scales for lumped modulators. Consequently the speed limitation is understood and alleviated by single-drive configuration, and comprehensive knowledge into the energy dependence on structural parameters significantly reduces energy consumption. The results show that silicon modulation energy as low as 80.8 and 21.5 fJ/bit can be achieved at 28 Gbd under 50 and 10 Omega impedance drivers, respectively. A 50 Gbd modulation is also shown to be possible. The analytical models can be extended to lumped modulators on other material platforms and offer a promising solution to the current challenges of modulation energy reduction. (C) 2017 Chinese Laser PressNational Natural Science Foundation of China (NSFC) [61120106012]SCI(E)ARTICLE2134-142
Author Arna Bontemps reads to children at the East Winston Branch Library, 1956.
No full textAuthor Arna Bontemps reads to children at the East Winston Branch Library, 1956
Using bacterial biomarkers to identify early indicators of cystic fibrosis pulmonary exacerbation onset
No full textAcute periods of pulmonary exacerbation are the single most important cause of morbidity in cystic fibrosis patients, and may be associated with a loss of lung function. Intervening prior to the onset of a substantially increased inflammatory response may limit the associated damage to the airways. While a number of biomarker assays based on inflammatory markers have been developed, providing useful and important measures of disease during these periods, such factors are typically only elevated once the process of exacerbation has been initiated. Identifying biomarkers that can predict the onset of pulmonary exacerbation at an early stage would provide an opportunity to intervene before the establishment of a substantial immune response, with major implications for the advancement of cystic fibrosis care. The precise triggers of pulmonary exacerbation remain to be determined; however, the majority of models relate to the activity of microbes present in the patient's lower airways of cystic fibrosis. Advances in diagnostic microbiology now allow for the examination of these complex systems at a level likely to identify factors on which biomarker assays can be based. In this article, we discuss key considerations in the design and testing of assays that could predict pulmonary exacerbations
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