2 research outputs found
Towards Improved Data Quality Management Tools in Logistics
No full textIn today’s logistics environment, high-quality data is essential for ensuring efficient processes and sustaining competitiveness.
However, missing, erroneous, or duplicate entries in master data often lead to significant business consequences, such as inefficient supply chains, increased operating costs, and poor decision-making.
Existing data screening, cleaning and scoring (DSCS) tools for detecting data errors and thus measuring data quality are often cumbersome to use and are not tailored to the specific needs of logistical master data.
In this paper, we present design knowledge to guide the development of DSCS tools.
We gathered requirements through dedicated workshops and distilled them into a set of actionable design features.
To evaluate our design features, we implemented them in a software prototype, which was tested in a usability and multi-case study. Our contribution in form of design features equips logistics practitioners with concrete guidance for creating and implementing effective DSCS tools in their organizations.2
Mechanical force induces mitochondrial fission
No full textEukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and fusion. Here, we show that mitochondrial fission is triggered by mechanical forces. Mechano-stimulation of mitochondria – via encounter with motile intracellular pathogens, via external pressure applied by an atomic force microscope, or via cell migration across uneven microsurfaces – results in the recruitment of the mitochondrial fission machinery, and subsequent division. We propose that MFF, owing to affinity for narrow mitochondria, acts as a membrane-bound force sensor to recruit the fission machinery to mechanically strained sites. Thus, mitochondria adapt to the environment by sensing and responding to biomechanical cues. Our findings that mechanical triggers can be coupled to biochemical responses in membrane dynamics may explain how organelles orderly cohabit in the crowded cytoplasm
