1,720,982 research outputs found
Diagnosis and differential diagnosis of multiple sclerosis
No full textThe diagnosis of multiple sclerosis is based on three main criteria. 1. dissemination in time, i.e. exacerbations and remissions or chronic progression of neurological symptoms, 2. dissemination in space, i.e. anatomically distinct lesions in the central nervous system and correspondingly, symptoms and signs which ore affecting different functional neurological systems, 3. evidence about the pathogenesis and differential diagnosis based on technical investigations (cerebrospinal fluid analysis, magnetic resonance tomography, evoked potentials) according to the present state of clinical research. To date, none of the established diagnostic guidelines proves to be fully satisfactory in each case. In many cases additional diagnostic efforts are necessary to exclude other causes of the disease and to achieve a high level of diagnostic probability
Diagnosis and differential diagnosis of multiple sclerosis
No full textThe diagnosis of multiple sclerosis is based on three main criteria. 1. dissemination in time, i.e. exacerbations and remissions or chronic progression of neurological symptoms, 2. dissemination in space, i.e. anatomically distinct lesions in the central nervous system and correspondingly, symptoms and signs which ore affecting different functional neurological systems, 3. evidence about the pathogenesis and differential diagnosis based on technical investigations (cerebrospinal fluid analysis, magnetic resonance tomography, evoked potentials) according to the present state of clinical research. To date, none of the established diagnostic guidelines proves to be fully satisfactory in each case. In many cases additional diagnostic efforts are necessary to exclude other causes of the disease and to achieve a high level of diagnostic probability
Phylogenetic analysis of known exogenous and endogenous retroviral sequences gag, pol, and env: Comparison with taxonomic structure and function of retroviruses
No full textImmunoadsorption in steroid-refractory multiple sclerosis
No full textMultiple sclerosis (MS) is an autoimmune disorder, with involvement of both the humoral and cellular components of the immune system. The use of plasma exchange (PE) in steroid-refractory relapses has become an integral part of national and international guidelines for the treatment of steroid-resistant relapses of MS with an efficacy of 40-70%. So far, 6 studies of immunoadsorption (IA) treatment in different forms of MS have been published, 4 of them in steroid-refractory MS relapses. These 4 studies revealed a significant clinical improvement in 73-85% of patients with steroid-refractory MS relapses. However in MS patients with non-active relapsing-remitting or secondary progressive course, there was no clinical improvement. Despite the limited number of patients and studies, these data suggest a reasonably similar efficacy of IA in the treatment of steroid-refractory MS relapses compared to PE. More prospective trials are needed to confirm and extend these results. (C) 2012 Elsevier Ireland Ltd. All rights reserved.Diamed (Cologne, Germany
Brachial plexopathy as an early manifestation of Ham/Tsp and successful treatment with Ifn-alpha
No full textRhabdomyolysis after intake of Venlafaxin
No full textVenlafaxin is a serotonine-noradrenaline reuptake inhibitor that is used for treatment of depression and concomitant anxiety disorders. We report on a 38 years old woman, who developed a generalised seizure, agitation and somnolence, fever, hyponatriemia, rhabdomyolysis and a tachyarrhytmia absoluta. In a blood sample, which was collected about one day after the ingestion of venlafaxin, we detected 12 ng/ml venlafaxin and 105 ng/ml of its active metabolite O-desmethyl-venlafaxin. Considering the pharmacokinetic of venlafaxin and O-desmethyl-venlafaxin toxic plasma levels of both substances can be calculated for the time when symptoms had occurred. Under treatment with volume, diuretics and substitution of electrolytes the patient recovered consciousness very quickly. However, serum levels of creatine-kinase increased steadily to a maximum of 14 926 U/I on day 3 and declined slowly thereafter. In addition, a tachyarrhytmia absoluta developed suddenly on day 4 and reversed spontaneously one day later. While seizures, fever, hyponatriemia and loss of consciousness are typical symptoms of intoxication with venlafaxin, rhabdomyolysis and the late occurrence of tachyarrhytmia absoluta are uncommon
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