690 research outputs found
Core outcome sets in medical research
Get PDFJamie Kirkham and Paula Williamson outline the importance of core outcome sets in medical research, and make suggestions on how to identify, select, and develop them as well as highlight some of the barriers to their us
Neurological complications and MRI
Get PDFCerebrovascular disease (cerebral infarction, intracranial haemorrhage, vasculopathy) are common manifestations of SCD associated with significant morbidity and mortality. These neurological complications and potential corresponding neuropsychological compromise may have devastating consequences for a child with SCD. This chapter aims to review the neurological complications in SCD using magnetic resonance imaging (MRI) as both a qualitative and quantitative tool for detecting abnormality. Advanced MRI pulse sequences, such as high-resolution 3D T1-weighted imaging for brain volumetrics, diffusion tensor imaging for white matter integrity and non-invasive perfusion MRI for cerebral blood flow measurement, can give additional information about the structure and function of brain tissue beyond the scope of conventional clinical imaging. These studies have set to establish quantitative biomarkers that relate to disease severity and neuropsychological sequelae
Diagnosis and management of selective fetal growth restriction in monochorionic twin pregnancies: a cross‐sectional international survey
No full textObjective: To identify current practices in the management of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies. Design: Cross-sectional survey. Setting: International. Population: Clinicians involved in the management of MCDA twin pregnancies with sFGR. Methods: A structured, self-administered survey. Main Outcome Measures: Clinical practices and attitudes to diagnostic criteria and management strategies. Results: Overall, 62.8% (113/180) of clinicians completed the survey; of which, 66.4% (75/113) of the respondents reported that they would use an estimated fetal weight (EFW) of <10th centile for the smaller twin and an inter-twin EFW discordance of >25% for the diagnosis of sFGR. For early-onset type I sFGR, 79.8% (75/94) of respondents expressed that expectant management would be their routine practice. On the other hand, for early-onset type II and type III sFGR, 19.3% (17/88) and 35.7% (30/84) of respondents would manage these pregnancies expectantly, whereas 71.6% (63/88) and 57.1% (48/84) would refer these pregnancies to a fetal intervention centre or would offer fetal intervention for type II and type III cases, respectively. Moreover, 39.0% (16/41) of the respondents would consider fetoscopic laser surgery (FLS) for early-onset type I sFGR, whereas 41.5% (17/41) would offer either FLS or selective feticide, and 12.2% (5/41) would exclusively offer selective feticide. For early-onset type II and type III sFGR cases, 25.9% (21/81) and 31.4% (22/70) would exclusively offer FLS, respectively, whereas 33.3% (27/81) and 32.9% (23/70) would exclusively offer selective feticide. Conclusions: There is significant variation in clinician practices and attitudes towards the management of early-onset sFGR in MCDA twin pregnancies, especially for type II and type III cases, highlighting the need for high-level evidence to guide management.</p
Intelligence quotient in paediatric sickle cell disease: a systematic review and meta-analysis.
No full textChildren with SCD and no apparent MRI abnormality have significantly lower IQ than healthy controls. In this chronic condition, other biological, socioeconomic, and environmental factors must play a significant role in cognition
Intelligence quotient in paediatric sickle cell disease: a systematic review and meta-analysis
No full textArterial spin labeling characterization of cerebral perfusion during normal maturation from late childhood into adulthood: normal 'reference range' values and their use in clinical studies
Get PDFThe human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence allowed quantification of changes in longitudinal relaxation time (T1) and equilibrium longitudinal magnetization (M0). We present mean and reference ranges for normal values of T1, M0, cerebral blood flow (CBF), bolus arrival time, and bolus duration in cortical gray matter, to provide a tool for identifying age-matched perfusion abnormalities in this age range in clinical studies. Cerebral blood flow and T1 relaxation times were negatively correlated with age, without gender or hemisphere differences. The same was true for M0 anteriorly, but posteriorly, males but not females showed a significant decline in M0 with increasing age. Two examples of the clinical utility of these data in identifying age-matched perfusion abnormalities, in Sturge-Weber syndrome and sickle cell anemia, are illustrated.Journal of Cerebral Blood Flow & Metabolism advance online publication, 5 February 2014; doi:10.1038/jcbfm.2014.17
A guide to Oregon fisheries: a short guide to some of the commonly caught commercial seafood species in Oregon
No full textby Jamie Doyle and Amanda J. Gladics.Title from PDF cover (viewed on July 6, 2020)."Last updated 5/13/2020 with 2019 landings data from the Oregon Department of Fish and Wildlife."This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
What Did Neoliberalism Change for Waste? by Jamie Furniss
No full textWhat Did Neoliberalism Change for Waste? The case of foreign waste collection companies in Cairo by Jamie Furniss, Oxford University Jamie Furniss did fieldwork for his doctoral dissertation on development and Cairo's garbage collectors between 2006 and 2010. To quote this article : FURNISS, J. (2012), "What Did Neoliberalism Change for Waste? The case of foreign waste collection companies in Cairo", Anthropology News 53(8), pp. 10-11. To contact the author: jfrnss[at]gmail[dot]com In Cairo, ..
What Did Neoliberalism Change for Waste? by Jamie Furniss
No full textWhat Did Neoliberalism Change for Waste? The case of foreign waste collection companies in Cairo by Jamie Furniss, Oxford University Jamie Furniss did fieldwork for his doctoral dissertation on development and Cairo's garbage collectors between 2006 and 2010. To quote this article : FURNISS, J. (2012), "What Did Neoliberalism Change for Waste? The case of foreign waste collection companies in Cairo", Anthropology News 53(8), pp. 10-11. To contact the author: jfrnss[at]gmail[dot]com In Cairo, ..
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