1,723,906 research outputs found
Design, implementation and test of an automatic measurement setup for high efficiency photovoltaic converters
No full textKiran Kumar GudisevaKlagenfurt, Alpen-Adria-Univ., Master-Arb., 201
Design, implementation and test of an automatic measurement setup for high efficiency photovoltaic converters
No full textKiran Kumar GudisevaKlagenfurt, Alpen-Adria-Univ., Master-Arb., 201
Pathways to Success and Excellence (16 True Inspirational Stories) by Kiran Kumar Singh.
Get PDFPathways to Success and Excellence (16 True Inspirational Stories) by Kiran Kumar Singh. Reviewed by Dr. Shaleen Kumar Singh, 1st Ed. 2023, Jaipur: Wisdom Words Publishing. ISBN: 978-93-90765-86-
THE CORPORAL ANAND KK (791316-N) MARULIPI SASTHRA BODHINI & KEY
No full textMarulipi is an alternative script for English was invented by Kamanuru Kiran Kumar from Andhra Pradesh in India. It was invented for diary writing
<b>Marubhasha</b>
No full textMarulipi is an alternative script for Telugu was invented by Kamanuru Kiran Kumar from Andhra Pradesh in India. It was invented for diary writing.</p
ELECTROMAGNETICS FOR ELECTRICAL MACHINES
No full text<p>It is general information that electrical energy is used in a variety of settings, and it is also common awareness that electrical machines play critical roles in manufacturing and other STEM-related industries. Because it is meant to assist both students and working engineers and technicians, this book was prepared with both sets of readers in mind: students and working professionals. The course "Electrical Machines" is taught differently at various universities and goes by a variety of different titles, including "Electrical Machines-I," "Electrical Machines-II," "DC Machines and Transformers," "Electromagnetic Energy Conversion Devices," "Special Purpose Machines," and so on. This section offers a comprehensive discussion of the subject matter that is normally covered in courses of this kind. This book highlights the modifications that have been made to the curriculum at all institutions, both in India and overseas, and those adjustments have been made. In spite of the fact that there are a great many textbooks devoted to this subject matter, the majority of students consider Electrical Machines to be one of the most challenging academic fields to study. Keeping this in mind, the content was developed in a logical manner, with an emphasis placed on the essentials. Because each chapter of the book has the required words, and because the accompanying illustrations are distinct and simple to comprehend, the majority of the content does not need much explanation. Throughout the course of the book, several more examples, both solved and unresolved, have been included as a means of assisting students in their preparation for the numerous sorts of questions that will be included on examinations. In order to facilitate consistent learning and the retention of information, a portion of practice problems has been included to each of the chapters. At the end of each chapter, there is a sufficient number of multiple-choice, shortanswer, and test questions, as well as unsolved situations. These elements combine to make the book an independent educational experience. There is no pretension made by the author that they conducted ground-breaking research for the book. The published works of well-known authors have provided us with access to a wealth of materials, which we have used to a significant degree. The author, on the other hand, is certain that his presentation is quite systematic. In addition to that, he mentions that the text is written in a way that is easy to understand and digest. A claim of this kind, despite the fact that every effort has been taken to assure correctness, is unlikely to be true in light of the circumstances. </p>
sj-docx-1-bbi-10.1177_11779322211056122 – Supplemental material for Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor
No full textSupplemental material, sj-docx-1-bbi-10.1177_11779322211056122 for Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor by Kiran Kumar Adepu, Sangita Kachhap, Andriy Anishkin and Sree V Chintapalli in Bioinformatics and Biology Insights</p
Supplemental Material - Platform Revolution in the Database Management System Industry: Evolution of SAP’s Business Model
No full textSupplemental Material for Platform Revolution in the Database Management System Industry: Evolution of SAP’s Business Model by Krishna Chandra Balodi, Rajesh Jain, T B Kiran Kumar and Debarati Banerjee in Journal of Information Technology Teaching Cases</p
Die Antikörper sezernierender B-Zellen als eines neuartigen therapeutischen Ansatzes zur Behandlung von allergischen Erkrankungen
No full textAllergische Erkrankungen haben in den letzten Jahrzehnten stetig zugenommen. Sie können sich an verschiedenen Organsystemen manifestieren, zu den häufigsten gehören die atopische Dermatitis und die Nahrungsmittelallergie. Allergien sind charakterisiert durch eine immunologisch vermittelte Überempfindlichkeit gegenüber harmlosen Antigenen. Die zugrunde liegende Pathophysiologie ist komplex und umfasst zahlreiche Effektorzellen und Moleküle. Plasmazellen produzieren Immunglobulin E, welches eine zentrale Rolle bei der Typ I Allergie spielt. Eine Möglichkeit Plasmazellen zu eliminieren, besteht über die Anwendung von Proteaseinhibitoren, somit könnten auch Immunglobuline eliminiert werden.
Ziel der vorgelegten Arbeit ist es Plasmazellen durch Hemmung des Proteasoms zu beeinflussen und die systemischen und lokalen Auswirkungen auf die allergische Immunantwort in Mausmodellen zu untersuchen. Zwei Allergiemodelle mit Manifestation an der Haut und des Gastrointestinaltraktes wurden untersucht.
Die Ergebnisse zeigen, dass nach Verabreichung des Proteasominhibitors Bortezomib in einem mit Allergen abhängig auftretendem Hautekzem Plasmazellen vermindert wurden und die systemische IgE aber auch IgG1- und IgA-Antwort reduziert war. Darüber hinaus waren T-Zellen in der Haut vermindert, jedoch fand sich kein Einfluss auf den klinischen Ausprägungsgrad.
Dagegen wurde in einem im Rahmen dieser Arbeit neu etablierten Nahrungsmittelallergiemodell nach Gabe von Bortezomib sowohl die klinischen Symptome als auch die B-Zellsubpopulationen einschließlich Plasmazellen und die systemische Immunantwort reduziert.
Zusammenfassend zeigen die vorgelegten Daten, dass durch eine Hemmung des Proteasoms Plasmazellen stark reduziert werden und in der Folge die humorale Immunantwort vermindert ist. Während in der Haut nach der Behandlung mit Bortezomib keine klinischen Veränderungen trotz der verminderten humoralen Immunantwort messbar waren, konnte in dem gastrointestinalen Allergiemodell nicht nur ein signifikanter Rückgang der humoralen Immunantwort sondern auch der klinischen Symptome beobachtet werden.
Schließlich zeigen die Ergebnisse, dass durch Elimination Antikörper produzierender B-Zellen allergische Erkrankungen, die sich am Gastrointestinaltrakt abspielen, wie die Nahrungsmittelallergie, jedoch nicht das atopische Ekzem beeinflussen lassen.Allergic diseases, which encompass atopic dermatitis and food allergy, are steadily increasing and characterised by a deviated immune response towards harmless antigens. The underlying pathophysiology is complex. Plasma cells secrete immunoglobulins of which IgE play a central role in immediate allergy. Proteasome inhibitors have been shown to target plasma cells and thereby eliminate immunoglobulins.
The objective of this thesis is to deplete plasma cells by proteasomal inhibition and to examine the consequences on the systemic and local immune response in murine models of allergy. Two different allergen-driven mouse models of allergy were applied, which display allergic symptoms caused by a deviated immune response. One of the models involves the skin and the other one the gastrointestinal mucosa as sites of the allergic response. The administration of the proteasomal inhibitor bortezomib in vivo in a mouse with allergen-induced atopic eczema led to a profound reduction of plasma cells thereby inhibiting the systemic IgE response but also IgG1 and IgA, although to a much lesser extent. Skin homing T cells were also largely reduced, but without improving the clinical severity. In contrast, in the newly established food allergy model intestinal anaphylactic symptoms in mice were alleviated and accordingly B cell subsets including plasma cells, but also systemic IgE and to some magnitude IgG1 were also significantly reduced after proteasomal inhibition.
In conclusion, bortezomib treatment leads to a strong reduction of plasma cells and consecutively the humoral immune response in both allergy models. The data indicates a different pathophysiological role of IgE in the two allergy models. In the skin, the local inflammatory response plays a major role to mount the eczematous skin reaction, whereas IgE-dependent mast cell activation seems to play a central role in the gastrointestinal mediated allergy. Taken together, the results demonstrate that targeting antibody-secreting B cells by bortezomib as a new therapeutic approach to treat gastrointestinal, but most likely not skin related allergic diseases
sj-docx-2-pie-10.1177_09544089211052738 - Supplemental material for Heat transfer enhancement using double taper microchannel
No full textSupplemental material, sj-docx-2-pie-10.1177_09544089211052738 for Heat transfer enhancement using
double taper microchannel by Pallikonda Mahesh, Kupireddi Kiran Kumar, Karthik Balasubramanian, Chandramohan VP, Poh Seng Lee and Chui Chee Kong in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering</p
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