1,144 research outputs found
Клинический опыт применения ополаскивателя полости рта "Антисептический" в комплексном лечении хронического катарального гингивита
No full textВ литературе последних лет дискутируется вопрос о том, что приводит к возникновению заболеваний краевого пародонта – нарушения в системном иммунитете или наличие микробов, которые влекут за собой снижение естественной резистентности организма (К.Н. Косенко, Т.П. Терешина, 2003; Ю.Г.Чумакова с соавт., 2002; Kinane D.F., Marshall G.J., 2001).
При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/3258
Late Roman amphora 1: a study of diversification
No full textThis paper draws on petrological work done by the author on the most important type of late Roman amphora - LR1, which was widely distributed in the Mediterranean, Red Sea area and western Britain
Letter from D.F. Goggin, Motor Officer, April 5, 1950
No full textIn this letter, D.F. Goggin, Motor Officer, affirms that Tsugitada Kanamori was employed by his organization starting June 8, 1946 and was still employed there at the time this letter was written. He remarks that Kanamori is a loyal and honest employee and recommends him for any position.This collection contains one box of documents belonging to Tsugitada Kanamori. Materials in this collection mostly pertain to Kanamori’s efforts regarding canceling his renunciation and reinstating his American citizenship
Reconstruction of turbulent pipe-flow profiles from laser Doppler velocimetry data
No full textLaser Doppler velocimetry (LDV) is a powerful experimental tool that finds increasing application in industrial research and product development. For example, LDV may be used to support the development of water, heat, and cooling meters as well as the design and validation of the associated testing and calibration facilities. For such applications, a basic quantity of interest is the volume flow rate Q that can be determined through numerical integration of the velocity profile over the measurement grid. However, under realistic experimental conditions, optical disturbances and reflections may cause corrupted and unreliable data at various measurement points. Here, we study a criterium to identify and reconstruct such data points. The reconstruction criterium is based on the standard error associated with each measurement point. Using some of our LDV data, we show that the error in Q with respect to a reference flow rate may be reduced significantly through the reconstruction. Consequently, the reconstruction criterium allows to establish accurate and reliable flow rates that have potential to be used as a primary validation reference
Clinical, pathological and immunological aspects of periodontal disease
No full textThe inflammatory and immune responses during the development and progression of periodontitis are reiewed. Susceptibility to periodontitis may be related to whether plasma cells predominate in the tissues of an individual, or a site, in response to the microbial insult from dental plaque. The tendency for an individual or site to form an extensive plasma cell infiltrate may indicate an inability to defend against periodontopathogenic bacteria and thus a predisposition to periodontitis. Selected pertinent areas of current interest in cellular and humoral immunology are considered within the periodontal context. These topical issues include (a) homing of immune and inflammatory cells to target tissues; (b) the local proliferation and synthetic activity of immune and inflammatory cells; (c) the cytokine profile of the inflammatory and immune cells; and (d) the immunoglobulin subclasses of locally produced antibodies
The immune processes in periodontal disease
No full textThe inflammatory and immune processes in periodontitis are complex and, although a great deal of information is available, many questions remain. Variation in human susceptibility to periodontitis has long been accepted, but the pathological basis of this is poorly understood. Similarly, we know little of the differences, if any, between the pathology of chronic and aggressive periodontitis. Genetics and environmental influences play a role in the susceptibility process, but if and how that translates through the immune and inflammatory processes to produce the plasma cell-dominated lesions seen in periodontitis remain to be elucidated. This review will focus on immunological aspects of the inflammatory changes seen in gingivitis and periodontitis, addressing both humoral and cellular responses to the microbial insult from dental plaque. A tendency for an individual or site to form an extensive plasma cell infiltrate may indicate an inability to defend against periodontopathogens and thus a predisposition to periodontitis. The issues to be considered include: 1) homing of immune and inflammatory cells to target tissues; 2) their local proliferation and synthetic activity; 3) the cytokine profile of the leukocytes; 4) the immunoglobulin subclasses of locally produced antibodies; 5) mucosal and systemic immune characteristics of the response; 6) the humoral immune response in periodontal health and disease states; and 7) the antigenic target of the immune response in periodontal lesions
Letter from D.F. Goggin, Motor Officer, to the American Consul, Yokohama, Japan, April 18, 1951
No full textThis letter confirms that Tsugitada Kanamori has worked for D.F. Goggin since June 1946 at the time this letter was written and has been a model employee.This collection contains one box of documents belonging to Tsugitada Kanamori. Materials in this collection mostly pertain to Kanamori’s efforts regarding canceling his renunciation and reinstating his American citizenship
Depolarization and decreased surface expression of K+ channels contribute to NSAID-inhibition of intestinal restitution
No full textNon-steroidal anti-inflammatory drugs (NSAIDs) contribute to gastrointestinal ulcer formation by inhibiting epithelial cell migration and mucosal restitution; however, the drug-affected signaling pathways are poorly defined. We investigated whether NSAID inhibition of intestinal epithelial migration is associated with depletion of intracellular polyamines, depolarization of membrane potential (Em) and altered surface expression of K+ channels. Epithelial cell migration in response to the wounding of confluent IEC-6 and IEC-Cdx2 monolayers was reduced by indomethacin (100μM), phenylbutazone (100μM) and NS-398 (100μM) but not by SC-560 (1μM). NSAID-inhibition of intestinal cell migration was not associated with depletion of intracellular polyamines. Treatment of IEC-6 and IEC-Cdx2 cells with indomethacin, phenylbutazone and NS-398 induced significant depolarization of Em, whereas treatment with SC-560 had no effect on Em. The Em of IEC-Cdx2 cells was: −38.5±1.8mV under control conditions; −35.9±1.6mV after treatment with SC-560; −18.8±1.2mV after treatment with indomethacin; and −23.7±1.4mV after treatment with NS-398. Whereas SC-560 had no significant effects on the total cellular expression of Kv1.4 channel protein, indomethacin and NS-398 decreased not only the total cellular expression of Kv1.4, but also the cell surface expression of both Kv1.4 and Kv1.6 channel subunits in IEC-Cdx2. Both Kv1.4 and Kv1.6 channel proteins were immunoprecipitated by Kv1.4 antibody from IEC-Cdx2 lysates, indicating that these subunits co-assemble to form heteromeric Kv channels. These results suggest that NSAID inhibition of epithelial cell migration is independent of polyamine-depletion, and is associated with depolarization of Em and decreased surface expression of heteromeric Kv1 channels.ID: S0006295207001931; M3: Article; Accession Number: S0006295207001931; Author: L.C. Freeman (b); Author: D.F. Narvaez (a); Author: A. McCoy (a); Author: F.B. von Stein (c); Author: S. Young (b); Author: K. Silver (a); Author: S. Ganta (b); Author: D. Koch (b); Author: R. Hunter (b); Author: R.F. Gilmour (c); Author: J.D. Lillich (a, ⁎); Affiliation: Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, United States; Keyword: Non-steroidal anti-inflammatory drugs; Keyword: Intestinal epithelial cells; Keyword: Membrane potential; Keyword: Potassium channels; Number of Pages: 12; Language: English;Source type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=edselp&AN=S0006295207001931&site=eds-live&scope=sit
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