1,721,079 research outputs found
Light-Induced Reactive-Oxygen-Species- (ROS-) Mediated Activation of Self-Assembled Nanoplatforms for On-Demand Drug Delivery
No full textSignificant research efforts have been devoted to the development of multifunctional nanoplatforms that can efficiently target and deliver therapeutic/diagnostic agents to diseased sites. In recent years, the use of internal or external stimuli to trigger drug release in a controlled or programmed fashion is emerging as a promising approach to the design and fabrication of smart drug carriers. Among various stimuli, light as an external source of energy has become a powerful tool for realizing precise drug delivery because it not only allows remote and accurate control of drug release but can also be easily focused into specific pathological areas such as tumor. Recently, the photosensitized cascade generation of reactive oxygen species (ROS) and cleavage of an ROS-sensitive linker have been utilized as a trigger to facilitate drug release at desired target sites. This book chapter highlights recent progress in the light-induced ROS-mediated activation of various self-assembled nanoassemblies for on-demand drug delivery. © 2019 American Chemical Society. All rights reserved.11Nscopu
Combining Ultrasonic and Vision Sensor Using Fuzzy Rules for Indoor Feature Extraction and Discrimination of a Mobile Robot
No full textTherapeutic-Gas-Responsive Hydrogel
No full textNitric oxide (NO) is a crucial signaling molecule with various functions in physiological systems. Due to its potent biological effect, the preparation of responsive biomaterials upon NO having temporally transient properties is a challenging task. This study represents the first therapeutic-gas (i.e., NO)-responsive hydrogel by incorporating a NO-cleavable crosslinker. The hydrogel is rapidly swollen in response to NO, and not to other gases. Furthermore, the NO-responsive gel is converted to enzyme-responsive gels by cascade reactions from an enzyme to NO production for which the NO precursor is a substrate of the enzyme. The application of the hydrogel as a NO-responsive drug-delivery system is proved here by revealing effective protein drug release by NO infusion, and the hydrogel is also shown to be swollen by the NO secreted from the cultured cells. The NO-responsive hydrogel may prove useful in many applications, for example drug-delivery vehicles, inflammation modulators, and as a tissue scaffold. ? 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.115sciescopu
A Method of Floor Plan Recognition by Using Ultrasonic Sensors for Mobile Robot Navigation
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