17,009 research outputs found
The clinical efficacy of pure-grind acellular dermal matrix without gelatin in lower extremity skin defect treatment: A prospective randomized study
No full textBackground: Acellular dermal matrix (ADM) is currently considered as a replacement for lost extracellular matrix. Trials have been conducted on dressing materials with high contents of ADM without any impurities, such as gelatin, which only undergo the grinding process. In this study, we aimed to investigate the clinical application and wound healing effect of pure-grind ADM in lower extremity skin defect treatment. Methods: Patients with skin defects in the lower extremities who did not achieve wound healing within 4 weeks with conservative treatment were enrolled in this study from March 2021 to July 2021. We randomized the patients into two groups. The patients in the experimental group were treated with pure-grind ADM and conventional negative-pressure wound therapy (NPWT), whereas the patients in the control group were only treated with NPWT. Every wound was followed-up for 7 weeks, and complete wound healing was confirmed when the skin defect was fully covered with epithelized tissue. Results: A total of 41 patients were enrolled in this study. Complete wound healing was observed in 73.2% of patients, and 26.8% had an unhealed status until the end of the follow-up. The pure-grind ADM did not promote complete healing (p = 0.796) and was not associated with epithelization time but promoted the velocity of epithelization (experimental 5.58 vs. 3.50 cm2/day, p = 0.020). Considering the time of healing, the decrease in wound depth was more extensive (p = 0.021), the speed of granulation tissue formation was higher, and this difference was more evident after 5 weeks of treatment in the experimental group. Conclusion: We demonstrated the clinical efficacy of pure-grind ADM in treatment of lower extremity skin defects. This new type of ADM, without any impurities, is important in wound healing. Its depth filling effect is powerful, and it can promote epithelization velocity and speed of granulation tissue formation. Copyright © 2022 Kim, Jeong, Kim, Park and Lee
Application of One Piece Autologous Rib Cartilage Graft in Hollow Space of Complete Naso-Ethmoid Orbital Fracture
No full textBACKGROUND: Complete naso-orbital-ethmoid (NOE) complex fractures including hollow space defects are difficult to treat. A proper bone fragment should be maintained for bony rearrangement and reconstruction; however, no guidelines are available for the treatment of the NOE complex. In patients with empty bone fragment from NOE fractures, implantation of autologous rib grafts may be an option for recreating the orbital rim. METHODS: A 57-year-old man with open complete NOE fracture. Computed tomography (CT) revealed complete loss of bone fragments within the NOE area, including the inferior orbital rim and maxillary wall. A bone was harvested from the right fifth rib. The grafted bone mimicked the inferomedial orbital rim and was stabilized with mid plates. RESULTS: Follow-up CT and three-dimensional (3D) volumetry were performed at 1, 3, 6, and 12 months. A well-positioned rib graft and orbital wall were observed. In 3D volumetry analysis, we noted that the absorption rate of the rib cartilage was 7.84% at 6 months. The absorption rate of rib cartilage was evaluated using CT images, which were reconstructed with a 3D image reconstruction program (Alpha-VIEW, Coreline soft, Seoul, Korea). CONCLUSIONS: Complete NOE fractures, especially fractures involving loss of the buttress for plating, may pose a burden to surgeons. In such cases, implantation of an autologous rib cartilage graft is a good option for bony frame reconstruction, without any concerns of bony resorption
Activity of α-Chymotrypsin Enhanced in the Presence of Iron Oxide Nanoparticles in Organic Solvent:
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SYNTHESIS OF OPTICALLY PURE (R)-2-HYDROXY ACIDS USING D-LACTATE DEHYDROGENASE
No full textSeveral (R)-2-hydroxy acids have been prepared in high optical purities and good yields using D-lactate dehydrogenase (Staphylococcus epidermidis) as the catalyst.open1121sciescopu
Magnetically Recoverable Palladium Nanocatalyst for Chemoselective Olefin Hydrogenation
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Hydrogenation of Aryl Ketones Using Palladium NanHydrogenation of aryl ketones using palladium nanoparticles on single-walled carbon nanotubes in an ionic liquid
No full textSingle-walled carbon nanotubes (SWNTs) are used as supporting materials for palladium (Pd) nanoparticles generated in situ in ionic liquid (IL); Pd nanocatalysts on SWNTs exhibit superior reactivity for hydrogenation of aryl ketones in IL under mild conditions (1 atm of H-2 (g) and room temperature) and can be reused above 10 times without any loss of catalytic activity. (C) 2010 Elsevier Ltd. All rights reserved.X119sciescopu
Room Temperature Solid-Phase Ionic Liquid-Immobilized Enzyme for Biocatalysis in Organic Solvent: Markedly Enhanced Enantioselectivity
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Total nasal reconstruction with a forehead flap: Focusing on the facial aesthetic subunit principle
No full textThe nasal aesthetic subunit principle has been widely accepted as the standard for nasal reconstruction with forehead flaps. However, in our experience, one's impression of a reconstructed face can easily be represented by the nose's entire appearance rather than a single nasal component. Accordingly, we hypothesized that total nasal reconstruction focusing more on the facial aesthetic subunit principle would be superior to focal nasal subunit partial reconstruction. Here, we investigated the indication range of total nasal reconstruction and analyzed its effectiveness. Between July 2006 and December 2017, 32 patients who underwent total or subtotal nasal reconstruction were recruited. The total nasal reconstruction group (n = 20) was treated according to our modified facial aesthetic unit concept, while the subtotal reconstruction group (n = 16) was treated according to the nasal aesthetic subunit principle. Using retrospective reviews, we compared surgical details and aesthetic, and functional outcomes with visual analog scale scores. In aesthetic evaluation, nose contour (p = 0.009), nasal symmetry (p = 0.001), and nostril shape (p = 0.041) were superior in the total nasal reconstruction group. Satisfaction regarding the nose (p = 0.036) was significantly higher than that regarding the forehead and labial folds in the total group. Regarding function, there were no significant intergroup differences in nasal airflow, snoring, or olfaction. We suggest that total nasal reconstruction is not a strategy to avoid because of its aggressive nature. For selected suitable patients, the use of the total nose reconstruction focusing on our one nose concept can be a successful surgical option, and the reconstructed nose can be visualized as a real part of the face
Synthesis of unsaturated C-8-C-9 sugars by enzymatic chain elongation
No full textthe syntheses of several unsaturated C-8-C-9 sugars have been accomplished by employing an enzymatic chain elongation based on rabbit muscle aldolase as the key step.open112sciescopu
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