1,721,120 research outputs found
Long-term oncologic outcomes of single-incision laparoscopic surgery for colon cancer
No full textBACKGROUND: Studies find similar perioperative outcomes between single-incision laparoscopic surgery (SILS) and conventional laparoscopic surgery (CLS) for colon cancer. However, few have reported long-term outcomes of SILS versus CLS. We aimed to compare long-term postoperative and oncologic outcomes as well as perioperative outcomes between SILS and CLS for colon cancer. METHODS: A total of 641 consecutive patients who underwent laparoscopic surgery for colon cancer from July 2009 to September 2014 were eligible for the study. Data from 300 of these patients were used for analysis after propensity score-matching (n = 150 per group). Variables associated with short- and long-term outcomes were analyzed. RESULTS: The SILS group had a shorter mean total incision length, less postoperative pain, and a similar mean rate of incisional hernia (2.7% versus 3.3%) compared with the CLS group. The 7-year overall and disease-free survival rates were 92.7% versus 94% (p = 0.673) and 85.3% versus 84.7% (p = 0.688) in the SILS and CLS groups, respectively. CONCLUSIONS: Compared with CLS, SILS for colon cancer appeared to be safe in terms of perioperative and long-term postoperative and oncologic outcomes. The results suggested that SILS is a reasonable treatment option for colon cancer for a selected group of patients
A 74%, 1.56-2.71 GHz, wide-tunable LC-tuned VCO in 0.35-mu m CMOS technology
No full textA wide-tuning monolithic LC-tuned VCO is presented. The proposed VCO wide, tuning hi utilizing binary weighted switched varactor combination operating at minimum or maximum value in addition to a linearly varying interpolation varactor. Measurements show 74% of tuning at it range of 1.56-2.71 GHz. with the phase noise ranging from -136 dBc/Hz to -108 dBc/Hz at 1 MHz offset. The VCO is implemented in 0.35-mum CMOS technology and dissipates 10.3 mA from a 3-V supply. (C) 2003 Wiley Periodicals, Inc
Comparison Study of Biosignal based Computer Interfaces Based on Fitts’ Law Paradigm
No full textThis paper presents development of two different biosignal based computer interfaces for people with motor disabilities: 1) electromyography (EMG)-based computer interface (ECI) and 2) hybrid EMG-based computer interface (HECI). The ECI made both movements of a cursor and clicking from muscle contractions induced by volitional wrist movements. On the other hand, the HECI made movements of a cursor from the lower arm movements under a motion capture camera, and clicking from muscle contractions induced by volitional movements of index and middle fingers. These interfaces were tested by the experiments based on a Fitts’ law paradigm in order to provide object evaluation of the interfaces. These results were also compared to a commercial brain computer interface was evaluated under the same test setup
The COVID-19 pandemic and clinical characteristics of colorectal cancer: a multicenter retrospective study
No full textThe spread of COVID-19 has led to numerous hospitals prioritizing case management and to delays in diagnosis and treatment. Consequently, many cancer patients have developed life-threatening complications during the COVID-19 pandemic. The aim of this study was to investigate the impact of COVID-19 pandemic on colorectal cancer (CRC), including its clinical and pathologic characteristics. This multicenter cohort study was performed at six institutions in Korea and included a total of 3871 patients with CRC treated between March 2019 and February 2021. After exclusion of 211 patients who did not undergo surgery, the data of 3660 patients were compared 1 year before and after the COVID-19 pandemic. The patients' baseline characteristics, CRC-related complications, perioperative outcomes including emergency surgery, R0 resection rates, stoma formations, postoperative complications, and pathologic outcomes were assessed. The number of patients decreased during the pandemic (- 18.0%, from 2127 to 1744), but the baseline characteristics did not differ. The pandemic group had greater disease severity given the presence of bleeding, perforation, and obstruction as complications (9.8% vs. 12.7%, P = 0.033). The proportion of patients who had open surgery (15.9% vs. 17.6%, P = 0.049), stoma formation (11.9% vs. 15.4%, P < 0.001), early postoperative complications (13.5% vs. 17.5%, P = 0.001), and adjuvant chemotherapy increased in the pandemic group (45.5% vs. 50.1%, P = 0.003). The clinical and pathologic features of CRC partly worsened during the pandemic. Healthcare providers and governments should prepare to encounter patients with CRC having poor clinical features for years and encourage people to participate in cancer screening programs. The Clinical Research Information Service (No. KCT0008063), January 2, 2023, retrospectively registered
A CMOS frequency synthesizer block for MB-OFDM UWB systems
No full textA CMOS frequency synthesizer block for multi-band orthogonal frequency division multiplexing ultra-wideband systems is proposed. The proposed frequency synthesizer adopts a double-conversion architecture for simplicity and to mitigate spur suppression requirements for out-of-band interferers in 2.4 and 5 GHz bands. Moreover, the frequency synthesizer can consist of the fewest nonlinear components, such as divide-by-Ns and a mixer with the proposed frequency plan, leading to the generation of less spurs. To evaluate the feasibility of the proposed idea, the frequency synthesizer block is implemented in 0.18-mu m CMOS technology. The measured sideband suppression ratio is about 32 dBc, and the phase noise is -105 dBc/Hz at an offset of 1 MHz. The fabricated chip consumes 17.6 mA from a 1.8 V supply, and the die-area including pads is 0.9 x 1.1 mm(2)
All CMOS low-power wide-gain range variable gain amplifiers
No full textTwo variable gain amplifiers (VGAs) that adopt new approximated exponential equations are proposed in this paper. The dB-linear range of the proposed VGAs is extended more than what the approximated exponential equations predict by a bias circuit technique that adopts negative feedback. The proposed VGAs feature wide gain variation, low-power, high linearity, wide control signal range, and small chip size. One of the proposed VGAs is fabricated in 0.18 mu m CMOS technology and measurements show a gain variation of 83 dB (-36 similar to 47 dB) with a gain error of less than +/- 2 dB, and P1 dB/IIP3 from -55/8 to -20/20.5 dBm, while consuming an average current of 3.4 mA from a 1.8 V supply; the chip occupies 0.4 mm(2). The other VGA is simulated in 0.18 mu m CMOS technology and simulations show a gain variation of 91 dB (-41 similar to 50 dB), and P1 dB/IIP3 from -50/-25 to -33/0 dBm, while consuming an average current of 1.5 mA from a 1.8 V supply
Integrative multi-omics deciphers the potential mechanism and microbial biomarkers for lymph node metastasis in colorectal cancer
No full textUnderstanding and accurate diagnosis of lymph node metastasis (LNM) for patients with colorectal cancer (CRC) is essential to determine treatment and follow-up strategies. Therefore, in this study, we aimed to elucidate the biological process and identify the potential biomarker for LNM in CRC.A total of 30 patients who received a histologically confirmed diagnosis of CRC with Stage I to III and a curative surgery between November 2020 and July 2021 at Kyung Hee university hospital at Gangdong were included. We performed multi-omics approach integrating the data on somatic mutation, transcriptomic expression, DNA methylation, and microbiome with tumor and adjacent matched normal tissues of each patient. In total, 12 significant DEGs between the patients with and without LNM were identified, consisting of significantly upregulated S100A8 gene, a proinflammatory gene. The GSEA revealed that gene sets involving "MULTI CANCER INVASIVENESS" in terms related to epithelial-mesenchymal transition was significantly upregulated in the patients with LNM. Integrated functional analysis of DNA methylation with transcriptome profile shows that significantly hypomethylated promoters of the genes are enriched for LNM. The phylum Proteobacteria, unassigned (p_PU) presented significantly higher proportions in cancer tissues from the adjacent normal tissues. Notably, when compared to the patients without LNM, the gut microbiota of those with LNM appears to exhibit a significantly lower abundance of the p_PU, indicating its potential as promising biomarker for LNM in CRC. We explained the mechanism of tumor spreading using multi-omics analysis and identified the relevant metagenomic biomarker to predict the LNM in CRC by the recognition of host-microbial interaction, thereby can make the cancer surveillance of the patients more individualized and convincing
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