712 research outputs found
sj-docx-1-jpc-10.1177_21501319231224711 – Supplemental material for Knowledge and Behavior of Primary Care Physicians Regarding Utilization of Standardized Tools in Screening and Assessment of Anxiety, Depression, and Mood Disorders at a Large Integrated Health System
No full textSupplemental material, sj-docx-1-jpc-10.1177_21501319231224711 for Knowledge and Behavior of Primary Care Physicians Regarding Utilization of Standardized Tools in Screening and Assessment of Anxiety, Depression, and Mood Disorders at a Large Integrated Health System by Abdul Waheed, Asif Khan Afridi, Masooma Rana, Mobeena Arif, Trajan Barrera, Feroza Patel, Muhammad Nausherwan Khan and Erum Azhar in Journal of Primary Care & Community Health</p
Repurposing FDA approved drugs against monkeypox virus DNA dependent RNA polymerase: virtual screening, normal mode analysis and molecular dynamics simulation studies
No full textZoonotic monkeypox disease, caused by the double-stranded DNA monkeypox virus, has become a global concern. Due to the absence of a specific small molecule drug for the disease, this report aims to identify potential inhibitor drugs for monkeypox. This study explores a drug repurposing strategy using virtual screening to evaluate 1615 FDA approved drugs against the monkeypox virus DNA dependent RNA polymerase subunit A6R. Normal mode analysis and molecular dynamics simulation assessed the flexibility and stability of the target protein in complex with the top screened drugs. The analysis identified Nilotinib (ZINC000006716957), Conivaptan (ZINC000012503187), and Ponatinib (ZINC000036701290) as the most potential RNA polymerase inhibitors with binding energies of - 7.5 kcal/mol. These drugs mainly established hydrogen bonds and hydrophobic interactions with the protein active sites, including LEU95, LEU90, PRO96, MET110, and VAL113, and residues nearby. Normal mode analysis and molecular dynamics simulation confirmed the stability of interactions between the top drugs and the protein. In conclusion, we have discovered promising drugs that can potentially control the monkeypox virus and should be further explored through experimental assays and clinical trials to assess their actual activity against the disease. The findings of this study could lay the foundation for screening repurposed compounds as possible antiviral treatments against various highly pathogenic viruses
The shifting world of South African madrasahs, 1973-2008
No full textIncludes bibliographical references (leaves 92-101).This essay seeks to unearth the historical development of madrasah education in South Africa from 1973 to 2008. It identifies transformations that have taken place in the madrasah education landscape in the last thirty to forty years. This work may be seen as largely an exercise in contemporary historical excavation. In addition to determining whether the transformations have changed or sustained the central function of madrasahs as spaces for religious socialization and sectarian identity formation, the essay is an attempt to underline the link between these changes and the broader shifts and developments that have taken place in Muslim communities and the country. The conclusion suggests that while major transformations have taken place at South African madrasahs, the changes - in a broader sense - still fall very much within the central function of madrasahs historically and globally. There has been no radical shift, or even a conception thereof, beyond often sectarian religious orthodoxy
The Intellectual Representative of the School of objective Criticism: Azhar Ghouri: مکتبۂ معروضی نقد ونظر کا فکری نمایندہ: اظہر غوری
No full textObject oriented approach of criticism has its roots in post continental philosophies based on perdiction and vision. Azhar Ghouri has strong advocacy for universalization of values and global adaptation of critical thinking styles. He believes in sublimity of Art and architecture regardless of classic or modern as a label for critical analysis. He believes in exploration of ideas and vision with insight in any piece of literature beyond its mechanical structure. Colonialism, exploitation, industrialisation, hunger, fear, shelter, peace and justice are controversial in global village according to A. G which needed to be reflected in art and literature in modes of individual’s interest. Author of this artical has explored gross root level realities and fundamental beliefs of object oriented approach in literary works of A.G. The agitation through pen has always been an eye opener initiative to stimulate the reader same has been highlighted by the author in the artical.
Reference:
Azhar Ghori ,do tehzibo ki dohri maanwiyat kay hamil afsanay,mazmoon mashmoola,jahan e rang o boo,az nayar aqbal alwi,Lahore,multi media,affairs,2005,s 7.
Azhar Ghori,Nazriyati murassa kaar afsaana nigar,Sami Ajaow,gair muratba,19 July,2023
Azhar Ghori,Takhliqi shaoor ki Shairi,Ghair muratba,2002.
Azhar Ghori,Awam dushman nizam ko badalnay ka muharak,,nukta nazer ,mutbuaa ,haft rooza,siraat ,2009.
Azhar Ghori,ghair mutboowa mazmmon,2021.
Azhar Ghori ,Tareikhi shasoor ki hamil shairi,ghair mutbuaa,16 junauary,2023.
Azhar Ghori,Sufaid jhoot,Dr uzma aziz khan kay shahkaar afsanchay,Lahore ,multi media affairs,2023,s.107
Spatial variability of soil micronutrients (Cu, Fe, Zn & Mn) and population dynamic of mycoflora in potato fields of CKNP region Gilgit-Baltistan Pakistan
No full textEntrepreneurial Leadership and Creativity in Projects: A Moderated-Mediated Mechanism.
No full textFor managers/leaders without creativity and innovation, it's difficult to compete effectively on the market. Employee top success is not often enough to achieve a strategic edge in which creative attitudes and innovation can be counted as materials to create. An entrepreneurial leadership style is recognised as a crucial source of enhancing creativity in project-based organisations. However current research will provide empirical evidence in which leadership leads to creativity in projects through Innovative Work Behaviour (IWB) and Entrepreneurial SelfEfficacy (ESE) as a moderator. For this purpose, the leaders/managers in the project-based organisations are in the twin cities of Peshawar and Nowshera, KP; Pakistan was taken as a population of the study. All the four variables were measured through adopted instruments from the previous studies. Due to time, cost and other constraints, the study has employed the convenience sampling technique to gathered data. The collected data was run through various statistical techniques such as data cleaning, internal consistency, CFA and relationship via Structural Educational Modelling using CB AMOS 23. The results of the study found that Entrepreneurial leadership has significant and positive association with creativity in projects. The study also examined that innovative work behaviour partially mediates the association between Entrepreneurial leadership and has significant and positive association with creativity in projects. Further, the study also found that entrepreneurial self-efficacy moderates the association between entrepreneurial leadership and has significant and positive association with creativity in projects
Istihsan (juristic preference) : the forgotten principle of Islamic law
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
The relevance of Muhammad Abduh's thought in indonesian tafsir; Analysis of Tafsir Al-Azhar
No full textIn this study, the author uses the descriptive-historical approach to explain the influence of Muhammad Abduh's thoughts and Tafsir Al-Manar's coming to Indonesia. Especially in the Tafsir Al-Azhar by Hamka, who was born in the 20th century. This interpretation emerged when Indonesia was experiencing a state of transition from colonialism to independence. At the same time, modern Islamic thought became strong in Indonesia. The modern approach of Tafsir al-Manar has inspired Hamka's model of interpretation in Tafsir Al-Azhar. Here the authors find similarities in terms of methodology, namely social-community (Adab ijtima'i). Apart from that, there are some similarities and differences between the Tafsir Al-Manar with Tafsir Al-Azhar. For example, the view of the verses of "Ahl Kitab, muhkam-mutasyabih, and Israiliyat." Then the implications for the understanding of the heterogeneous Indonesian Islamic community from various religions. Besides this, the interpretation had a significant influence on the development of modern interpretation in Indonesia. It is easy to read and understand the general public to academics in Indonesia, Malaysia, and other Southeast Asian countries
The Relevance of Muhammad Abduh's Thought in Indonesian Tafsir: Analysis of Tafsir Al-Azhar
No full textIn this study, the author uses the descriptive-historical approach to explain the influence of Muhammad Abduh's thoughts and Tafsir Al-Manar's coming to Indonesia. Especially in the Tafsir Al-Azhar by Hamka, who was born in the 20th century. This interpretation emerged when Indonesia was experiencing a state of transition from colonialism to independence. At the same time, modern Islamic thought became strong in Indonesia. The modern approach of Tafsir al-Manar has inspired Hamka's model of interpretation in Tafsir Al-Azhar. Here the authors find similarities in terms of methodology, namely social-community (Adab ijtima'i). Apart from that, there are some similarities and differences between the Tafsir Al-Manar with Tafsir Al-Azhar. For example, the view of the verses of "Ahl Kitab, muhkam-mutasyabih, and Israiliyat." Then the implications for the understanding of the heterogeneous Indonesian Islamic community from various religions. Besides this, the interpretation had a significant influence on the development of modern interpretation in Indonesia. It is easy to read and understand the general public to academics in Indonesia, Malaysia, and other Southeast Asian countries
Clinical Presentation of Alzheimer Disease (ad): a hospital based observational study.
No full textIntroduction: Alzheimer's disease (AD) is a neurodegenerative illness that mani-fests itself clinically and pathologically.Objective: To identify the various patterns of Alzheimer’s disease (AD) in adults.Methodology: A hospital based observational study was conducted in the Depart-ment of Neurology Jinnah Postgraduate Medical Centre (JPMC) Karachi, Pakistan from May 2018 to November 2019.Cases with complaint of memory impairment and/or cognitive impairment, with or without behavioral changes were included in the study. Acute delirious state uremia / hepatic encephalopathy hypo / hypergly-cemia and hypo / hypernatremia were excluded diagnosis. The main outcome measures were clinical patterns of AD with age and sex distribution, affective disor-der with cognitive impairment (Pseudo dementia) and affective disorder without cognitive impairment.Results: A sample of 51 cases (36 males and 15 females) with memory impairment was included. Age’s between 25-85years (mean 57years). Out of 51 cases 44 had probable /possible Alzheimer’s disease (AD) 03 had affective disorder with cogni-tive impairment (pseudo dementia), 04 patients had affective disorder without cognitive impairment. Among probable / possible cases of AD 23 (52.27%) had multi infarct dementia (having history of past cerebrovascular disease), same sta-tistics among Parkinson’s patient’s i.e. diagnosis was Parkinson’s disease with memory impairment were 18 (40.90%) followed by alcoholic dementia in 03 (6.8%). There was no definite Alzheimer’s disease case in this study.Conclusion: Vascular dementia not the definite Alzheimer’s disease is the com-monest memory impairment type presentation in our study. Among Parkinson’s disease patient’s dementia was found quite high in our study.Keywords: Alzheimer’s disease (AD), Vascular dementia (MID), Parkinson’s disease (PD), Cognition, Memory
- …
