2,400 research outputs found
Autism Awareness in the Church with Dr. Kevin Timpe
No full textSpecial Guest, Dr. Kevin Timpe, joins host, Tyler Fowler, of the Faith Unaltered Podcast for an in-depth interview about effectively serving those Christians that have been diagnosed with Autism
Elements of Abstraction: Space, Line and Interval in Modern British Art
No full textThe book is the catalogue of the exhibition Elements of Abstraction: Space, Line and Interval in Modern British Art, which the author curated from the collections of the Tate Gallery, London, the Arts Council, London, Southampton City Art Gallery and private collections. The author provided three essays, 'The Geometry of Modern British Art', 'West Country Constructivism', and 'Abstract Art and the Decline of Modernism' to advance critical histories of three distinct moments of importance in the development of British abstract art. A fourth, edited by him, was by a research student under his supervision (Alan Fowler) and covered Systems Art and Constructionism
Fowler Block
No full textPhotograph - Fowler Block, Athabasca, Alberta. The building was built in the early 1950s by G.G. Fowle
Houses Built by Gilbert G. Fowler
No full textPhotograph - Houses built by Gilbert G. Fowler for his daughters and their husbands, Athabasca, Albert
IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling
No full textIt is known that differentiation of Th17 cells is promoted by activation of STAT3 and inhibited by activation of STAT1. Although both transcription factors are activated by several cytokines, including IL-6, IL-21, and IL-27, each of these cytokines has a very different effect on Th17 differentiation, ranging from strong induction (IL-6) to strong inhibition (IL-27). To determine the molecular basis for these differences, we measured STAT3 and STAT1 activation profiles for IL-6, IL-21, and IL-27, as well as for cytokine pairs over time. We found that the ratio of activated STAT3/activated STAT1 is crucial in determining whether cytokines promote or inhibit Th17 differentiation. IL-6 and IL-21 induced p-STAT3/p-STAT1 ratios > 1, leading to the promotion of Th17 differentiation, whereas IL-27 or IL-6+IL-27 induced p-STAT3/p-STAT1 ratios < 1, resulting in inhibition of Th17 differentiation. Consistent with these findings, we show that IL-27 induces sufficient p-STAT3 to promote Th17 differentiation in the absence of STAT1. Furthermore, IL-27-induced STAT1-deficient T cells were indistinguishable from bona fide highly proinflammatory Th17 cells because they induced severe experimental autoimmune encephalomyelitis upon adoptive transfer. Our results suggest that the ratio of p-STAT3/p-STAT1 induced by a cytokine or cytokine pairs can be used to predict whether they induce a competent Th17-differentiation program
Writing from life
No full textThe author and artist Martin Fowler will talk about his recent publications, 'Scotland the brave: a graphic history of Scotland 1514-2014' and 'The tension of a line: a portrait of Perth Prison', in conversation with the author and journalist Bill Jamieson
Policy-Making at the Fowler FCC: How Speeches Figured In
No full textPart of the legacy of FCC Chairman Mark Fowler are the speeches in which he advocated his theory of deregulation. The author, Fowler\u27s legal advisor and principal speech-writer, states his view of the Fowler chairmanship, indicating which speeches were intended, at least by those in office, to be the milestones of that period. He offers an appraisal of the successes and failures of the chairmanship. Additionally, he generalizes about the limits of the speech-making function at an administrative agency, given its responsibility to Congress
Policy-Making at the Fowler FCC: How Speeches Figured In
No full textPart of the legacy of FCC Chairman Mark Fowler are the speeches in which he advocated his theory of deregulation. The author, Fowler\u27s legal advisor and principal speech-writer, states his view of the Fowler chairmanship, indicating which speeches were intended, at least by those in office, to be the milestones of that period. He offers an appraisal of the successes and failures of the chairmanship. Additionally, he generalizes about the limits of the speech-making function at an administrative agency, given its responsibility to Congress
The FCC under Mark Fowler: A Mixed Bag
No full textThe FCC\u27s performance under Chairman Mark Fowler (1981-87) calls for a mixed verdict, in the author\u27s estimate. Fowler\u27s reliance on competition, the marketplace, and deregulation, fit the common carrier area, but ill served the present public interest standard of the Communications Act in the broadcast field. This article assesses FCC activities in this period in the above two fields, and also in the cable television and spectrum areas
- …
