2 research outputs found
Impact of a Static Magnetic Field on Early Osseointegration: A Pilot Study in Canines
No full textA static magnetic field generated by neodymium–iron–boron (NdFeB) magnets placed in the inner cavity of dental implants can enhance bone regeneration in rabbits. It is, however, unknown whether static magnetic fields support osseointegration in a canine model. We therefore determined the potential osteogenic effect of implants carrying NdFeB magnets inserted in the tibia of six adult canines in the early stages of osseointegration. Here, we report that after 15 days of healing, magnetic and regular implants showed a high variation with a median new bone-to-implant contact (nBIC) in the cortical (41.3% and 7.3%) and the medullary (28.6% and 44.8%) region, respectively. Consistently, the median new bone volume/tissue volume (nBV/TV) in the cortical (14.9% and 5.4%) and the medullary (22.2% and 22.4%) region were not significantly different. One week of healing only resulted in negligible bone formation. These findings suggest that considering the large variation and the pilot nature of this study, magnetic implants failed to support peri-implant bone formation in a canine model
High physical activity is associated with decreased fungiform papillae area and number, elevated sucrose recognition thresholds, and increased IL-6 levels: an observational human study
No full textBackground: Disease-related inflammation affects chemosensory signaling, but knowledge on the impact of exercise-induced low-grade inflammation on taste function remains scarce. Here we hypothesized that intense habitual physical activity modifies sweet taste perception via increased cytokine release.
Methods: In an observational human study we compared participants (m/f) engaging in high (n = 34) and low (n = 31) levels of habitual physical activity. Salivary IL-6 and urinary 8-iso-prostaglandin F2α levels, body composition, sucrose recognition threshold, preference and consumption of sweet foods, size and area of fungiform papillae as well as selected hormones regulating food intake were recorded. Statistical analysis was conducted using Principal Component Analysis (PCA) followed by Student’s t-tests and multiple regression models.
Results: The PCA summarized the main outcome variables to two principal components (PC). PC1 was primarily influenced by body composition and fungiform papillae markers, while sucrose recognition thresholds, sweet food consumption, and IL-6 levels strongly contributed to PC2. Compared to the low activity group, the high activity group showed on average an increased sucrose recognition threshold (+ 35.8 ± 12.8%), increased IL-6 concentrations (+ 25.6 ± 10.9%), higher consumptions of sweet foods (+ 18.8 ± 4.9%) and decreased number (24.8 ± 4.9%) and area (-29.8 ± 6.4%) of fungiform papillae.
Conclusions: The association between modified sweet taste function markers and increased IL-6 levels suggests that inflammatory processes may contribute to exercise-related changes in chemosensory perception.Open Access funding enabled and organized by Projekt DEAL.Universität Hohenheim (3153
