1,721,202 research outputs found
RECOGNITION OF NMR PROTON SPIN SYSTEMS OF CYCLOSPORIN A VIA HETERONUCLEAR PROTON CARBON LONG-RANGE COUPLINGS
No full textCOMPARISON OF 4 PULSE SEQUENCES FOR THE ROUTINE APPLICATION OF PROTON CARBON SHIFT CORRELATION
No full textTRANSFORMATION OF HOMONUCLEAR TWO-DIMENSIONAL NMR TECHNIQUES INTO ONE-DIMENSIONAL TECHNIQUES USING GAUSSIAN PULSES
No full textPEPTIDE CONFORMATIONS .42. CONFORMATION OF SIDE-CHAINS IN PEPTIDES USING HETERONUCLEAR COUPLING-CONSTANTS OBTAINED BY TWO-DIMENSIONAL NMR-SPECTROSCOPY
No full textDETERMINATION OF CARBON CARBON CONNECTIVITIES, ASSIGNMENT OF QUATERNARY CARBONS, AND EXTRACTION OF CARBON CARBON COUPLING-CONSTANTS BY CARBON-RELAYED HYDROGEN CARBON SPECTROSCOPY
No full textDetermination of Connectivities via small Proton-Carbon Couplings with a new Two-Dimensional NMR Technique
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THE ELUCIDATION OF THE CONSTITUTION OF GLYCOPEPTIDES BY THE NMR SPECTROSCOPIC COLOC TECHNIQUE
No full textHighly Ordered Gold Nanopatterned Indium Tin Oxide Electrodes for Simultaneous Optical and Electrochemical Probing Cell Interactions
Full text linkThe formation of new types of sensitive conductive surfaces for the detection and transduction of cell–extracellular matrix recognition events in a real time, label-free manner is of great interest in the field of biomedical research. To study molecularly defined cell functions, biologically inspired materials that mimic the nanoscale order of extracellular matrix protein fibers and yield suitable electrical charge transfer characteristics are highly desired. Our strategy to achieve this goal is based on the spatial self-organization of patches of cell-adhesive molecules onto a gold-nanoparticle-patterned indium tin oxide electrode. Fibroblast adhesion response to selective ligands for integrins α5β1 and αvβ3, which are both relevant in cancer progression, is investigated by simultaneous electrochemical impedance spectroscopy and optical microscopy. Adhesive cells on α5β1-selective nanopatterns showed enhanced membrane dynamics and tighter binding, compared with cells on αvβ3-selective nanopatterns. The surface of the electrode exhibits high sensitivity to small changes in surface properties, because of the constitution of specific cell-surface interactions. Moreover, such sensitivity enables differentiation between cell types. This is exemplified by analyzing distinct features in the electrochemical readout of MCF-7 breast cancer cells versus MCF-10A mammary epithelial cells, when subjected to individual adhesive nanopatches.Fil: Pallarola, Diego Andres. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bochen, Alexander. Technische Universitat Munchen; AlemaniaFil: Guglielmotti, Victoria. Universidad Nacional de San Martin. Instituto de Nanosistemas; ArgentinaFil: Oswald, Tabea A.. Max Planck Institute for Medical Research; Alemania. Heidelberg University; AlemaniaFil: Kessler, Horst. Technische Universitat Munchen; AlemaniaFil: Spatz, Joachim P.. Max Planck Institute for Medical Research; Alemania. Heidelberg University; Alemani
CONFORMATIONAL-ANALYSIS OF AMINO-ACID SIDE-CHAINS IN PEPTIDES BY QUANTITATIVE-EVALUATION OF CROSS-PEAKS IN COLOC-SPECTRA
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