1,721,419 research outputs found
Tell me your apps and I will tell you your mood: Correlation of apps usage with Bipolar Disorder State
Full text linkBipolar Disorder is a disease that is manifested with cycling periods of polar episodes, namely mania and depression. Depressive episodes are manifested through disturbed mood, psychomotor retardation, behaviour change, decrease in energy levels and length of sleep. Manic episodes are manifested through elevated mood, psychomotor acceleration and increase in intensity of social interactions. In this paper we report results of a clinical trial with bipolar patients that amongst other aspects, investigated whether changes in general behaviour of patients due to onset of a bipolar episode, can be captured through the analysis of smartphone usage. We have analysed changes in smartphone usage, specifically app usage and how these changes correlate with the self-reported patient state. We also used psychiatric evaluation scores provided by the clinic to understand correlation of the patient smartphone behaviour before the psychiatric evaluation and after the psychiatric evaluation. The results show that patients have strong correlation of patterns of app usage with different aspects of their self-reported state including mood, sleep and irritability. While, on the other hand, the patients’ application usage shows discernable changes in the period before and after psychiatric evaluation
Feeling for affective psychosis
No full textThe paper presents new research results on the pathogenesis of depression and mania and future perspectives on diagnosis and treatment. On the one hand, we know that depression most often develops in the interplay between genes and the environment; and, on the other hand, that depression and mania may be induced suddenly by deep brain stimulation of the subthalamic areas. Ongoing studies aim to identify biomarkers for depression and mania, and results from recent research suggest that neuroticism, abnormal response to the DEX-CRH test, increased frontotemporal serotonine 2A binding, abnormal emotional processing and deceased executive function may be candidates for such biomarkers. These biomarkers may help to improve diagnosis and treatment in the future. Udgivelsesdato: 2009-Fe
Should long-acting injectable antipsychotics be used earlier and more frequent in bipolar disorder, type I?
No full textThe use of antidepressants for bipolar disorder - a controversy between science and clinical practice
No full textDepressive episodes are more challenging for patients and clinicians than other bipolar disorder episodes. The reasons for this include: 1. the prevalence of depressive episodes is higher than for other episodes; 2. functioning; 3. cognition is more impaired; 4. suicide is more prevalent; 5. and treatment is more complex. This paper aims to highlight the controversy between the poor evidence from science on the effects of antidepressants for bipolar depression versus the high use of antidepressants in clinical practice, and to specify the clinical role of antidepressants in bipolar disorder in relation to other drugs.</p
A call for research in early intervention and biological changes during the course of affective disorders:a comment on the review by Robert M. Post
No full textWhy is lithium [not] the drug of choice for bipolar disorder? a controversy between science and clinical practice
No full textBackgroundDuring over half a century, science has shown that lithium is the most efficacious treatment for bipolar disorder but despite this, its prescription has consistently declined internationally during recent decades to approximately 35% ever use or less of patients with bipolar disorder.ContentThis narrative review provides an overview of the decreasing use of lithium in bipolar disorder internationally, shortly summarises the evidence for lithium’s acute and prophylactic effects in bipolar disorder, discuss the challenges in relation to lithium including side effects, long-term risks and myths around lithium and provides two detailed examples on how specialised care models may result in successful increase of the use of lithium to 70% of patients with bipolar disorder largescale and improve care regionally and nationally.ConclusionsDecades of scientific investigations and education and teaching of clinicians and the public has not increased the use of lithium on a population-based large scale. It is argued that lithium should be the drug of choice for maintenance therapy as the single first-line treatment and that organizational changes are needed with specialised care for bipolar disorder to systematically and long-term change the use of lithium on a large-scale population-level.Background: During over half a century, science has shown that lithium is the most efficacious treatment for bipolar disorder but despite this, its prescription has consistently declined internationally during recent decades to approximately 35% ever use or less of patients with bipolar disorder. Content: This narrative review provides an overview of the decreasing use of lithium in bipolar disorder internationally, shortly summarises the evidence for lithium’s acute and prophylactic effects in bipolar disorder, discuss the challenges in relation to lithium including side effects, long-term risks and myths around lithium and provides two detailed examples on how specialised care models may result in successful increase of the use of lithium to 70% of patients with bipolar disorder largescale and improve care regionally and nationally. Conclusions: Decades of scientific investigations and education and teaching of clinicians and the public has not increased the use of lithium on a population-based large scale. It is argued that lithium should be the drug of choice for maintenance therapy as the single first-line treatment and that organizational changes are needed with specialised care for bipolar disorder to systematically and long-term change the use of lithium on a large-scale population-level.</p
Depression and the risk for dementia
No full textDepression is associated with increased risk of subsequent development of dementia; however, the nature of the association is still poorly understood. The purpose of the review was based on recent studies to discuss whether depression is a prodromal state of dementia or an independent risk factor for dementia, as well as to discuss how the type of depression, the type of dementia, and antidepressant treatment influence the association
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