9,436 research outputs found
Magneto–Optical Kerr Effect Microscopy Investigation on Permalloy Nanostructures
No full textThis thesis focuses on the investigation of magnetic domains in ultrasmall permalloy (Ni80Fe20) structures down to nanometre size. Magnetic domains and domain walls in nano objects are often observed using a very high resolution and high power microscope such as magnetic soft x-ray microscope, magnetic force microscopy imaging and photoemission electron microscopy. A reason for this is because the Kerr signal in nanostructures is very weak. However the results from this thesis demonstrate that magnetic domains in permalloy magnetic nanostructures can still be observed with very good contrast using a Magneto-optical Kerr effect (MOKE) microscope. The constructed Kerr microscope is a home-build wide field microscope and is able to produce magnetic domains image of permalloy nanowire as small as 245 nm, although the resolution limit of the microscope is 505 nm. For the first time, a magnetic domain in nanowire with width of 245 nm is observed using a wide-field microscope. The combination of hysteresis loops and magnetic domains observations for studying a magnetic sample provides a three-dimensional understanding of the magnetic characteristic of the sample. This is crucial in investigating nano samples as the theoretical arguments with the experimental results are always constrained by the experimental part. Three kinds of nanostructure sample were observed using the Kerr microscope; a cross nanowire, zigzag nanowire and a nanowire with notch and a nucleation pad at one end. It was found that a cross nanowire can form magnetic domains upon reversal and the junction forms a magnetisation vortex. Findings from zigzag nanowire demonstrate a complex, multiple magnetic domains formation upon magnetisation reversal. A weak domain wall pinning effect was observed in the nanowire, causing a multiple domains formation in the nanowire upon reversal. It can be confirmed that this effect was caused by the high coercivity of the nucleation pad. For the nanowire with notch, it was demonstrated that the coercivities were different at negative and positive field. But for such case, there is a relationship observed between the percentage notch depth and the coercivity at the junction
AKSW/LLM-KG-Bench: 1.1.0
No full text<p>release for DL4KG 2023 Turtle KG evaluation paper submission</p>
KG-Hi-BKF Benchmark for Biomedical Knowledge Fusion
No full textThe KG-Hi-BKF benchmark datasets for the biomedical knowledge integration task, which is proposed in our SIGIR'2023 paper: "HiPrompt: Few-Shot Biomedical Knowledge Fusion via Hierarchy-Oriented Prompting".
There are two datasets:
SDKG-DzHi
repoDB-DzHi
Under each dataset, the files are organized as follows:
ent_attr_KG.json
ent_attr_Hi.json
rel_trip_KG.csv
hypo_hyper_pair_Hi.csv
ent_links.csv
zero_shot/
|-- test_ent_links.csv
one_shot/
|-- support_ent_links.csv
|-- test_ent_links.csv
where `ent_attr*.json` denotes entity attribute files, `rel_trip_KG.csv` denotes knowledge graph relational triples, `hypo_hyper_pair_Hi.csv` denotes hierarchy hyponym-hypernym term pairs, and `ent_links.csv` denotes all aligned entity-term pairs.
The two subfolders `zero_shot/` and `one_shot/` provide the support&test split used in the paper.
If you use the datasets, please cite our paper
```BibTex
@inproceedings{lu23HiPrompt,
title = {HiPrompt: Few-Shot Biomedical Knowledge Fusion via Hierarchy-Oriented Prompting},
author = {Lu, Jiaying and Shen, Jiaming and Xiong, Bo and Ma, Wengjing and Staab Steffen and Yang, Carl},
year = {2023},
month = {Apr.},
Series = {SIGIR 2023},
Booktitle = {46th International ACM SIGIR Conference on Research and Development in Information Retrieval - Short Paper},
}
```</p
Stroombestendigheid stortsteen 60-300 kg
No full textOnderzoek in de stroomgoot van Lith naar de stabiliteit van breuksteen onder belasting door stroming (steen 60/300 kg) ten behoeve van de afsluiting van de Markizaatskade.KWP-collectio
The effectiveness of interventions to treat severe acute malnutrition in young children: a systematic review
No full textSevere acute malnutrition (SAM) arises as a consequence of a sudden period of food shortage and is associated with loss of a person’s body fat and wasting of their skeletal muscle. Many of those affected are already undernourished and are often susceptible to disease. Infants and young children are the most vulnerable as they require extra nutrition for growth and development, have comparatively limited energy reserves and depend on others. Undernutrition can have drastic and wide-ranging consequences for the child’s development and survival in the short and long term. Despite efforts made to treat SAM through different interventions and programmes, it continues to cause unacceptably high levels of mortality and morbidity. Uncertainty remains as to the most effective methods to treat severe acute malnutrition in young children.ObjectivesTo evaluate the effectiveness of interventions to treat infants and children aged < 5 years who have SAM.Data sourcesEight databases (MEDLINE, EMBASE, MEDLINE In-Process & Other Non-Indexed Citations, CAB Abstracts Ovid, Bioline, Centre for Reviews and Dissemination, EconLit EBSCO and The Cochrane Library) were searched to 2010. Bibliographies of included articles and grey literature sources were also searched. The project expert advisory group was asked to identify additional published and unpublished references.Review methodsPrior to the systematic review, a Delphi process involving international experts prioritised the research questions. Searches were conducted and two reviewers independently screened titles and abstracts for eligibility. Inclusion criteria were applied to the full texts of retrieved papers by one reviewer and checked independently by a second. Included studies were mapped to the research questions. Data extraction and quality assessment were undertaken by one reviewer and checked by a second reviewer. Differences in opinion were resolved through discussion at each stage. Studies were synthesised through a narrative review with tabulation of the results.ResultsA total of 8954 records were screened, 224 full-text articles were retrieved, and 74 articles (describing 68 studies) met the inclusion criteria and were mapped. No evidence focused on treatment of children with SAM who were human immunodeficiency virus sero-positive, and no good-quality or adequately reported studies assessed treatments for SAM among infants < 6 months old. One randomised controlled trial investigated fluid resuscitation solutions for shock, with none adequately treating shock. Children with acute diarrhoea benefited from the use of hypo-osmolar oral rehydration solution (H-ORS) compared with the standard World Health Organization-oral rehydration solution (WHO-ORS). WHO-ORS was not significantly different from rehydration solution for malnutrition (ReSoMal), but the safety of ReSoMal was uncertain. A rice-based ORS was more beneficial than glucose-based ORSs, and provision of zinc plus a WHO-ORS had a favourable impact on diarrhoea and need for ORS. Comparisons of different diets in children with persistent diarrhoea produced conflicting findings. For treating infection, comparison of amoxicillin with ceftriaxone during inpatient therapy, and routine provision of antibiotics for 7 days versus no antibiotics during outpatient therapy of uncomplicated SAM, found that neither had a significant effect on recovery at the end of follow-up. No evidence mapped to the next three questions on factors that affect sustainability of programmes, long-term survival and readmission rates, the clinical effectiveness of management strategies for treating children with comorbidities such as tuberculosis and Helicobacter pylori infection and the factors that limit the full implementation of treatment programmes. Comparison of treatment for SAM in different settings showed that children receiving inpatient care appear to do as well as those in ambulatory or home settings on anthropometric measures and response time to treatment. Longer-term follow-up showed limited differences between the different settings. The majority of evidence on methods for correcting micronutrient deficiencies considered zinc supplements; however, trials were heterogeneous and a firm conclusion about zinc was not reached. There was limited evidence on either supplementary potassium or nicotinic acid (each produced some benefits), and nucleotides (not associated with benefits). Evidence was identified for four of the five remaining questions, but not assessed because of resource limitation.LimitationsThe systematic review focused on key questions prioritised through a Delphi study and, as a consequence, did not encompass all elements in the management of SAM. In focusing on evidence from controlled studies with the most rigorous designs that were published in the English language, the systematic review may have excluded other forms of evidence. The systematic review identified several limitations in the evidence base for assessing the effectiveness of interventions for treating young children with severe acute malnutrition, including a lack of studies assessing the different interventions; limited details of study methods used; short follow-up post intervention or discharge; and heterogeneity in participants, interventions, settings, and outcome measures affecting generalisability.ConclusionsFor many of the most highly ranked questions evidence was lacking or inconclusive. More research is needed on a range of topic areas concerning the treatment of infants and children with SAM. Further research is required on most aspects of the management of SAM in children < 5 years, including intravenous resuscitation regimens for shock, management of subgroups (e.g. infants < 6 months old, infants and children with SAM who are human immunodeficiency virus sero-positive) and on the use of antibiotics.FundingThe National Institute for Health Research Technology Assessment programme.<br/
Narasin effects on energy, nutrient, and fiber digestibility in corn-soybean meal or corn-soybean meal-dried distillers grains with solubles diets fed to 16-, 92-, and 141-kg pigs1
No full textThree experiments were conducted to determine the effect of narasin on growth performance and on GE and nutrient digestibility in nursery, grower, and finishing pigs fed either a corn-soybean meal (CSBM) diet or a CSBM diet supplemented with distillers dried grains with solubles (DDGS), in combination with either 0 or 30 mg narasin/kg of diet. In Exp. 1 (64 gilts, initial BW = 9.0 kg, SD = 1.0 kg) and Exp. 2 (60 gilts. initial BW = 81.1 kg, SD = 6.1 kg), gilts were allotted into individual pens and fed their experimental diets for 24 and 21 d, respectively. On the last 2 d of each experiment, fecal samples were collected to assess apparent total tract digestibility (ATTD) of GE and various nutrients. In Exp. 3, 2 separate groups of 24 gilts (initial BW = 145.1 kg, SD = 7.8 kg) were allotted to individual metabolism crates and fed their experimental diets for 30 d prior to a time-based 6-d total fecal collection period to assess GE and nutrient digestibility. In Exp. 1, there was an interaction between diet type and narasin addition for G:F and for many of the ATTD coefficients measured. When narasin was supplemented to the CSBM diet, ATTD of GE, DM, C, S, phosphorus, NDF, and ADF was either not changed or reduced, while when narasin was supplemented to DDGS diets, these same ATTD parameters were increased (interaction, P ≤ 0.05). Even though ADG and ADFI were not affected, G:F] was improved in pigs fed the CSBM diet with supplemental narasin, but was reduced in pigs fed the DDGS diet with supplemental narasin (interaction, P This article is published as Kerr, B. J., S. L. Trabue, and D. S. Andersen. "Narasin effects on energy, nutrient, and fiber digestibility in corn-soybean meal or corn-soybean meal-dried distillers grains with solubles diets fed to 16-, 92-, and 141-kg pigs." Journal of animal science 95, no. 9 (2017): 4030-4036. DOI: 10.2527/jas.2017.1732. Posted with permission.</p
Acute Ethanol Administration Rapidly Increases Phosphorylation of Conventional Protein Kinase C in Specific Mammalian Brain Regions in Vivo
No full textBackground
Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central nervous system including neurotransmitter release, ion channel activity, and cell differentiation. Growing evidence suggests that specific isoforms of PKC influence a variety of behavioral, biochemical, and physiological effects of ethanol in mammals. The purpose of this study was to determine whether acute ethanol exposure alters phosphorylation of conventional PKC isoforms at a threonine 674 (p-cPKC) site in the hydrophobic domain of the kinase, which is required for its catalytic activity.
Methods
Male rats were administered a dose range of ethanol (0, 0.5, 1, or 2 g/kg, intragastric) and brain tissue was removed 10 minutes later for evaluation of changes in p-cPKC expression using immunohistochemistry and Western blot methods.
Results
Immunohistochemical data show that the highest dose of ethanol (2 g/kg) rapidly increases p-cPKC immunoreactivity specifically in the nucleus accumbens (core and shell), lateral septum, and hippocampus (CA3 and dentate gyrus). Western blot analysis further showed that ethanol (2 g/kg) increased p-cPKC expression in the P2 membrane fraction of tissue from the nucleus accumbens and hippocampus. Although p-cPKC was expressed in numerous other brain regions, including the caudate nucleus, amygdala, and cortex, no changes were observed in response to acute ethanol. Total PKC? immunoreactivity was surveyed throughout the brain and showed no change following acute ethanol injection
Plagiat
No full text<![CDATA[Nach der glanzvollen Premiere der "Dreigroschenoper" beschuldigte der Kritiker Alfred Kerr Bert Brecht, er habe wortwörtlich Passagen aus der Dichtung François Villons übernommen. Ungerührt antwortete Brecht: "Meiner Meinung nach gehört auch das Abschreiben zum Handwerk des Schriftstellers!" (Peter Frank, Der Büchernarr. Heiteres aus der Welt des Buches, München/Wien 1981, S. 147f. - eine weitere Anekdote aus dem Büchlein in ARCHIVALIA).]]
Models analyzed and summaries of model selection for the influence of biological variables (litter type, maternal age, study program), and environmental variables on birth mass (kg) of captive white-tailed deer from the Kerr Wildlife Management Area, Kerr County, TX from 1977–2012.
No full text<p>Each model contained predictor variables for litter type, age of the mother, and study program and added predictors for each model are shown below. Precipitation was calculated as the total precipitation (mm) in a month or range of months. Temperature was calculated as the mean maximum temperature (°C) per month or range of months. Number of parameters in each model is K, AIC<sub><i>c</i></sub> is the Akaike value for each model, ΔAIC<sub><i>c</i></sub> is the change in value compared to the most highly selected model and Weight is the Akaike weight for each model. Models are arranged from highest to lowest Akaike weight.</p><p>Models analyzed and summaries of model selection for the influence of biological variables (litter type, maternal age, study program), and environmental variables on birth mass (kg) of captive white-tailed deer from the Kerr Wildlife Management Area, Kerr County, TX from 1977–2012.</p
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