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    Kent Historical Society Garden Tour: Honoring the 200th Birthday of Marvin Kent

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    Kent Historical Society Historic Kent Town Tour Honoring the 200th Birthday of Marvin Kent September 17 & 18, 2016 10 a.m. to 5 p.m. Saturday and Noon to 5 p.m. Sunday East Side Tour Sites D Clapp-Woodward House/Kent Historical Society Museum D Erie Depot D Marvin Kent Train Car D Erie Car Shops * D Wells-Sherman House * Interior accessible only during guided tours at 1 p.m. & 2 p.m. each day West Side Tour Sites Patton House D Charles H. Kent Home D Marvin Kent House/ D Kent Masonic Center All sites are open and can be visited on either Saturday or Sunday. 1his tour booklet is your ticket and will be marked at each stop. e 0 (1) ---- "tl .... ~ · ·· ·········· ► s. Ql u5 j <f) 0 Summit St. East Side Tour Sites 0 Kent Historical Society e Hometown Plaza e Wells/Shennan House ;z. A ~ V Erie Depot - Marvin Kent Car (") ~ 0 Erie Shops fa Esplanade ekno so ethini about history, too! We are celebrating our 65th year serving our friends and neighbors! &ufa<t t4e ~ ad tk ~ ~ "Kent f4t μn 5Uta,,,e ~~- "Jlle atze &e4aed ta de a juVtt 1 tt! vVith appreciation to The Kent Historical Society for keeping history alive in Kent, Ohio 1 In saluting the Kent family we would like to tell of the historic connection with the family to Hometown Bank. Early commercial banks such as the Kent Nationa1 Bank,which was owned primarily by the Kent Family, were not of the habit of lending on a long term basis to finance housing. Seeing the need for this type of lending, Marvin Kent helped facilitate the chartering of our bank as an Ohio Chartered Building and Loan to specialize and encourage home ownership in the community of Kent and its surrounding area. His Cashier ( the Executive Managing Officer of the Bank) at the Kent National Bank, a young man by the name of W. H. C. Parkhill, became an incorporator of the new institution as well as five other local prominent business leaders. Mr. "'~ William Hamilton Clarke Parkhill ~.. Parkhill became our first Treasurer and the guiding banking mind behind the newly chartered Building and Loan. This could not have happened without the blessing of Marvin Kent. Incidentally, Mr. Parkhill was the husband of Marvin Kent's niece Helen Wells. So in saluting Marvin Kent on his 200th birthday we would also like to salute his nephew W. H. C. Parkhill because with his early guidance and banking knowledge we have been able to serve his community for the past .118 years. Thank you, Mr. Parkhill. Hometown Banking Since 1898 www.htbnk.com 2 MEMBER FDIC Clapp-Woodward House (Now Kent Historical Society Museum) 237 E. Main St. Built in 1883 In 1883, either Harriet Kent Clapp, eldest of Zenas Kent's 13 children, or her son Charles began building the house on land Harriet inherited from her father. Harriet had married Charles Clapp, but when he joined the Shaker religious community, she chose to leave him behind, living alternately in Kent with her son, Charles, or in Brooklyn, N.Y., with her brother, Henry Kent. Charles lived here with his wife, Mary Eliza Wood, and their four sons, Charles, Frank, Leon and Harold. Leon's initials were scrolled on the plaster wall in the front parlor, where they remain. The Victorian house features high ceilings, large rooms trimmed with carved cherry woodwork, three sets of pocket doors and a large entryway with an elaborate staircase. It also has four unique fireplaces and sits atop the hill on East Main Street with dignity and beauty. In 1912, the Clapps sold their home to John and Jeanette (Greenshield) Woodward, who lived here with their son Paul, 6, and daughter, Josephine "Jo," for just 19 months. Woodward owned the Woodward Coal Co. Jo was in the first kindergarten class at Kent Normal School and later at­tended both Kent State University and the Cleveland School of Arts. She studied Russian ballet with the famous Nijinsky in New York City, but her father's illness brought her back to Kent, where she married John Solem. They operated Solem Jewelry at the corner of Main and DePeyster streets until May 1970. The home was sold to Keller Electric in 1956, but Jo built a duplex on the Columbus Street end of the property, where she lived until her death at age 96 in 2007. In December 2010, the Kent Historical Society purchased the home from its fourth owner, Mary and Bob Paton, who had already done some restoration. The society's historic remodeling will continue to preserve this building as its home for generations. It is open to the public from 9 a.m. to 2 p.m. Fridays and Saturdays or by appointment for group tours or research by calling 330-678-2712. 3 Erie Railroad Depot Second Floor \ 152 Franklin Ave. Built in 1875 The first railroad depot in Kent was simply a large wooden box of a building for people to wait for trains and where freight could be depos­ited or picked up. By 187 4, the citizens of Kent asked the Atlantic & Great Western Railroad to build a better depot for their growing community. The railroad agreed, provided the town would pay 4,000oftheestimated4,000 of the estimated 10,000 cost. Under the direction of Marvin Kent, townspeople oversub­scribed and this second depot opened in 1875. Constructed oflocal brick in classic Tuscan design, it was second only to Cleveland's in size. Inside the depot's first floor was a large waiting room for passengers, a lunch counter and space for freight shipments. It has three large towers. The central tower contained living quarters to house the agent; later this space was given over to the people who worked at the downstairs lunch counter, such as the Elgin family, who had two daughters born there. The south tower contained beds where train crews could rest and sleep on their layovers. The railroad's agent, George Hinds, placed books in the north tower for the crewman to borrow and read. As the number of crewmen increased, they could not all sleep in the depot tower and the Erie Railroad decided it was not in the library business. The books became part of Kent's Carnegie Library built in 1902. The depot was the place where news came first via telegraph, where pas­sengers got their first vivid impressions of Kent, where soldiers and sailors left their families on their way to war and finally how countless students arrived to study at Kent Normal School, and later at Kent Sate University. In January 1970, the last trains departed Kent. Over the next 10 years, the new Kent Historical Society purchased and restored the station, utilizing plans by Cleveland architect Robert Gaede. It is still owned and preserved by the Kent Historical Society. 4 Marvin Kent Train Car 152 Franklin Ave. Built in 1922 The railroad coach "Marvin Kent" was manufactured by the American Car and Foundry Co. in 1922 for use by the Chicago, Burlington and Quincy Railroad. The car known as Coach 6125 saw service west of Chicago until acquired by the Lake Shore Railway Historical Society in 1969. It was stored in Ashtabula, Ohio, until purchased by the Kent Jaycees in the summer of 1976 for use as a meeting hall for both Jaycees and community use. When the car was moved to Kent in August of that year, the Jaycees leased the parcel of land south of the .Erie Depot from the Kent Historical Society. The Jaycees completely refurbished the car over the next four years. With an original seating capacity of 83, the coach measures 75 feet in length and 10 feet in width and stands 14 feet above the ground. It weighs 82 tons. The Erie Railroad had dedicated a sleeping car here in Kent in 19 51 to the memory of Marvin Kent, the Ohio president of the Atlantic & Great Western Railroad. The Jaycees felt that their car would be a fitting tribute to the memory of Marvin Kent and his importance to the railroad industry in Kent. The Jaycees' car is painted to resemble that sleeping car. The car is still used by the Jaycees and is connected to all city services and is air con­ditioned for summer use. It was recently repainted in its original colors. Young professionals age 18 to 40 interested in the Junior Chamber of Commerce Oaycees) can attend a monthly membership meeting on the second Wednesday of every month at 7 p.m. Email [email protected] for more information. 5 Erie Car Shops 200 W. Williams St. Built in 1863 Interior accessible only during guided tours at 1 p. m. & 2 p.m. each day When the Adan tic & Great Western Rail-road opened in 1863, the company established shops in Franklin Mills (Kent). Marvin Kent's influence as the railroad's president - and his gift of land valued at $15,000 - brought a complex of buildings that would be the center of the town's economy for nearly 60 years. Built by some of the same German-American masons who had built the canal lock here 20 years earlier and constructed of local stone, the shops were impressive. The main building was two stories high with three cupolas. The employment of several hundred men - including at times more than half of all working men in the town - increased the population dramatically, adding many new homes on Kent's south side. By 1918, some 800 workers worked for A & GW's successor, the Erie Railroad. The shops turned out hundreds of cars. While some locomotives were manufactured in the 1870s, the majority were wooden passenger and freight cars for the Erie. Workers were highly skilled mechanics and artisans as well as unskilled laborers. The grounds were full of lumber, barrels of nails and screws, wheel sets and supplies like paint and glass. The passenger cars in particular were real works of beauty, while the box cars, gondolas, cabooses and others were built solidly enough to last for decades. The work was hard, injuries were common and, in the winter, it was cold. A 12-hour workday was normal with no overtime. The car shops also functioned as a sort of public square and the community often gathered there to hear a band concert or see fireworks on holidays. There were some labor struggles along with the Erie's perpetual financial crises. After a major strike in 1922, the car shops closed in 1930. 4 The Davey Compressor Co., started by Paul Davey, purchased what re­mained of the shops in 1943. After several changes over the ensuing years, Tom Myers, Paul Davey's grandson, started leasing space in the building in 1981. His company, Davey Drill Division of Davey, Kent, Inc., continues the drill operations of its predecessor, Davey Compressor Co. 6 Kent Wells Sherman House 247 N. Water St. Built in 1858 The Greek Revival-styled Kent Wells Sherman House was built on the northeast corner of South Water and Erie streets in 18 5 8 for Frances Kent Wells, sister of city namesake Marvin Kent, and her husband George. George Wells was a business partner of Zenas Kent in the Wells and Kent Glassworks. After the Wells family sold the house and moved to Brownsville, Pa., in 1863, it was eventually acquired in 1868 by Dr. Aaron M. Sherman. He was a Civil War surgeon, prominent civic promoter, state representative, and one of the founders in 1866 of the Kent Unitarian-Universalist Church. The house was moved from its original site to East Erie Street, closer to Kent Normal College. By 2012, the house, which had been used as a student boarding house since 1968, was obtained by Kent State University for the purpose of demolition to make way for the university Esplanade. Research by avid local historians documented beyond question its signifi­cant historical value to the city of Kent. As a result, the community rallied and it was moved to its current location in September 2013. The structure, placed in commercial zoning, now hosts attorneys' offices, a video company and serves as a meeting place for public and private gatherings. It is an example of a public-private partnership. Along with grants, donations and many hours of volunteer work, significant financial and logistical support from KSU (arranged by retired Vice President Greg Floyd), the city of Kent, Hometown Bank, and Kent Historical Society, are gratefully acknowledged. This project serves as an example of what is neces­sary to save buildings that are of historical importance to a community. For information on using the building for meetings, parties or pop-up retail space, please contact Ann Ward at [email protected] or Rick Hawksley at [email protected]. 7 £mbracind t.ie fFuture ... . . . tYet .7fonorind Our (Past BISSLER & SONS Funeral Home and Crematory .'. ~ ~~-- --~-~=---·--·--_~ ·- ----~~-:>:..~"-- -. -- ------------~~--------..,..-~ ----_---·-~ 3~.,L..,;...., --;.~_::__:- -. 628 WEST MAIN STREET KENT, OHIO 44240 (330) 673-5857 www.BisslerandSons.com OSELECTED Independent "FUNERAL HOMES® ?vi.ember by Invitation 8 MEMBER Order of the Golde1i Rule N t ii5 :i C ti Q) .c 0 (/) u5 u Q) Q. (/) e a. z u5 &1 Q. C/J e a. (/) u5 "§ -~Q) u5 "§ Q) a.. (/) e West Side Tour Sites 0 Maivin Kent House e Patton House 0 Charles Kent House ~!,Z Martin ~~ ·· ... &Soos. lne. Industrial Machinery Specialists 330-673-8712 www.rwmai:tin.com The former Congregational Church, the third church in Franklin Mills (now Kent), was ded icated on November 30, 1858, two years before t he election of Abraham Lincoln to the Presidency in 1860. It served the Congregationa lists for almost a century, until 1955. 310 Park Avenue was purchased by the Martin fami ly in 1969 and currently serves as the corporate headquarters for R.W. Martin & Sons, Inc. 9 Patton House 529 W. Main St. Built in 1902 Once known as the Patton Memorial House, the family res­idence of W.W. Patton, his wife, Harriet, and daughter, Emma, was built in 1902. Among many community positions, Patton served as Kent's postmaster and superin­tendent of Kent schools (1872-1878). Having studied at both the Boston and Oberlin Conservatories of Music, Emma returned to Kent to provide music lessons in her beautiful home. Upon her death in 1939, Emma bequeathed the Patton House to Coterie, a ladies organization founded in 1896. This "circle of friends," which formed from the merger of a literary club and a cooking club, was chosen to maintain the property and provide space for community groups to gather. Women of prominent Kent families who were active members of Coterie in its early years include Mrs. Harry Longcoy, Mrs. Edward Parsons, Mrs. Duncan Wolcott, Mrs. W.S. Kent, Mrs. Frank Elgin, Mrs. Roy Smith and Mrs. Burt Spelman. Having served as the home for Kent State University presidents Dr. James Engleman and Dr. Karl Leebrick from 1939 to 1942, the formidable front porch and pleasant large rooms of the Patton House have welcomed many area social events. A lovely stained glass window provides a focal point at the landing of the stairway leading to a large second floor, which houses the family who oversees the property. The decor includes many of the original elements, from the hand-carved oak foyer to the antique grand piano Emma used to share her love of music with her students. Many of her original furnishings remain, as well. The home continues in the care of the 125 members of five Kent Cote­ries who strive to maintain this historic dwelling, which stands, regally, at the west entrance to downtown Kent. This historic meeting site is available to rent for groups of up to 50. For information, call 330-673-5221 or email [email protected]. Charles H. Kent Home 125 N. Pearl St. Built in 1843 The Charles H. Kent home was built in 1843 in the West Main Street district and is now located at 125 N. Pearl St. This home was designed and built by James Clark of Streetsboro Village, and is an example of Gothic Revival architecture. It also features elements of the Greek Revival and Carpenter Gothic architectural styles. Charles was the son of Zenas, two years younger than his brother Marvin, and was married to Mary E. Burrett. Charles was involved in the dry goods business with his father in Ravenna. When our community was still called Franklin Mills, Charles was a partner in the Clapp, Spellman & Kent Dry Goods business and also in a glass company with his brother Marvin. In 1860, he opened a dry goods and wallpaper store in Kent and also was an original investor and a director of the Kent National Bank. Charles died in 1887. In 1902, the house was moved 150 feet north of its original location along West Main Street to the current site on North Pearl Street by its then-owner, Henry Green. This was supposedly prompted by Martin L. Davey, son of the founder of the Davey Tree Co. Martin, who would later serve as a mayor of Kent, U.S. representative and eventually governor, persuaded Mr. Green to move the house to avoid its demolition for apart­ments the owner was constructing on the original site. This home is also referred to as the Palmer House after its longtime own­er, Dr. Maurice B. Palmer, who had accepted a position on the chemistry staff of Kent State Normal College in 1931. He and his wife, Louisa Fen­ton, purchased the home in 1940 and lived in it for more than 50 years. After the Palmers' death, the house fell into disrepair, and was completely renovated by Dennis and Jennifer Baughman. Mr. Baughman's company specializes in the renovation and preservation of historic homes. It was , placed on the National Register of Historic Places on Feb. 23, 1978. 11 Marvin Kent Family Homestead (Now Kent Masonic Center) 409 W. Main St. Built in 1884 Construction began in 1880 on the Eastlake-style homestead of Mar­vin and Maria Kent. Kent hired local craftsmen except for wood carvers, who came from Cleveland and New York. Much of the materials used in the house were likely locally sourced since, among Kent's many businesses, were a stone quarry and a plate glass factory. The wood for the home was the finest Kent could find in northern Ohio. When the Main Street cov­ered bridge was torn down, Kent saved the best of the massive beams and used one for the arch header near the west coach entrance. There are three similar arch headers in the west entrance hall and the main center hall. Among the home's remarkable features are walls and partitions of solid brick, cellar walls and entrance of thick sandstone, and a sloped slate roof. Completed in 1884, the home provided 7,335 square feet of living space with 20 rooms, including a ballroom and 10 fireplaces. During the 40 years the Kent family lived in the home, four U.S. pres­idents, either before or after they were in office, were guests in the home. When Warren G. Harding, William Howard Taft, William McKinley and Benjamin Harrison visited, they slept in the southeast second-floor bedroom. This room remains much as it was in those days, including the furniture. When William Kent died in 1923, the home became the property of the heirs of Marvin's son, Henry Lewis. They sold the home to Rockton Lodge 316 F & A. M. on Nov. 1, 1923. The Masons have initiated a nonprofit society, the Kent Home Preserva­tion Society, to raise funds and coordinate the restoration of the home to its 1923 status or earlier. The society is open to anyone with an interest in preserving the Marvin Kent Homestead. 12 THE BURBICK PoUNDATION IS PROUD TO SPONSOR THE HISTORIC KENT TOWNTOUR The Burbick Foundation EX OBSCURITATE IN LUCEM 13 A BRIEF HISTORY OF MARVIN KENT AND His FAMILY By jean Griffith Booth I would like to thank Don Booth, Howard Boyle and Sandy Halem for their valuable assistance in compiling this history. For purposes of clarity, I have used birth names for the women in this article. The Pilgrims Marvin Kent's ancestors were part of the Great Migration of 20,000 pil­grims who left England to come to New England between 1629 and 1640. The Puritan families who made this dangerous voyage were educated and prosperous. Among the first of Marvin's family to arrive in the Massachu­setts Bay Colony were: his fifth great-grandparents, William Hosford and wife Florentia Sarah Hayward, who came in 1630; his sixth great-grandpar­ents, Thomas Talmadge and wife Catherine Cromwell, arriving in 1633, and his fifth great-grandparents Henry Glover and wife Ellen Wakeman, who arrived in 1634. Making the journey in 1640 were Thomas Kent and his wife Ann Noyes with at least three children - eight-year-old Thomas, six-year-old Samuel (Marvin's fourth great-grandfather) and three-year-old Josiah. The Revolutionary War Both of Marvin's grandfathers, Zenas Kent (his father's father) and Oliver Hiram Lewis (his mother's father), fought in the Revolutionary War as privates in the Connecticut Line. On May 5, 1777, Zenas enlisted in the 4th Regiment of the Connecticut Militia for a term of eight months. During his service, the 4th Connecticut fought in the Defense of Philadelphia Campaign, including the Battles of Brandywine, Germantown and Whitemarsh, arriving at Winter Quarters at Valley Forge in mid-December, 1777. He was discharged Jan. 1, 1778. Oliver fought in the Revolutionary War three times, beginning in 1776 when he joined the 18th Regiment of the Connecticut Militia. He was a member of Captain Thomas Bidwell's Company and took part in the Bat­tle of New York on Aug. 27, 1776, and the Battle of Fort Washington on Nov. 16, 1776, before completing his term of enlistment. The Kent Family Settles in Ohio In the early 1800s, Aaron Olmsted hired Ralph Buckland, whose mother was Mary Olmsted, to survey and act as an agent for the land he had purchased in the Connecticut Western Reserve. It is likely Zenas and his wife Anne Plumb purchased their homestead in Mantua from Ralph, since Ralph was married to the Kents' eldest daughter, Ann. Traveling by sleigh, 14 the Kent and Buckland families left Leyden, Mass., and Middletown, Conn., in the winter of 1812. The younger Zenas came with his family, but his pregnant wife Pamelia Lewis remained back east. Sadly, two-year­old Mary Anne Buckland did not survive the journey. Zenas Kent The younger Zenas returned to Connecticut for Pamelia and they moved to Hudson in 1814. Using the skills he had learned from his fathe

    Playing with Fire: Understanding the Sunni-Shi'a Sectarian Lifecycle

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    This article discusses the ingrained impediments which are likely to stifle India's rise and growth - a phenomenon which has figured prominently in scholarly and official assessments, in India and outside, for over a decade now. Intriguingly India's rise as a global power has already been adjudged a certainty in these assessments, but the author contends that there exists an apparent disjuncture between how the world sees India and the prevailing internal impediments. Therefore, any assessment of India as a global power without incorporating these impediments would be incomplete, misplaced and hyperbolic. Of late, in the light of India's growing internal and external socio-economic and political difficulties, more and more writings and proclamations by Indian and international experts indicate emerging scepticism over India's potential as a global power. This paper takes a rollcall of India's internal impediments including, human development, institutional and security challenges which according to the author have already begun restraining India's global ascent.Griffith Business School, Griffith Asia InstituteFull Tex

    Understanding Indirect/Covert Aggression Within the Workplace Context: The Target’s Cognitive Process

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    Indirect/covert aggression is a set of behaviours employed by an individual (the aggressor) intended to create and inflict damage on another individual (the target) undetected (Einarsen, 1999). Indirect/covert aggression is employed within the workplace because displaying overtly aggressive behaviours toward peers, subordinates, and supervisors is generally considered socially unacceptable. Indirect/covert aggressive behaviours typically entail various circuitous behaviours, such as: vexatious rumour mongering, social isolation, and undermining professional competencies (Baron & Neuman, 1996; Neuman & Baron, 1998). Whilst previous research demonstrates that indirect/covert aggression is costly to organisations and individuals who experience it (e.g., absenteeism, employee turnover, and low performance), several issues require exploration to better understand the phenomenon, and before such workplace behaviours can be reduced. The most salient issues are identifying why individuals become the focus of indirect/covert aggression and determining the cognitive scripts (i.e., mental structures of knowledge) and behavioural scripts (i.e., behavioural performances that are applied to a specific situation, see Gioia & Poole, 1984) that they use to respond to these behaviours.Thesis (PhD Doctorate)Doctor of Philosophy (PhD)Griffith Business SchoolGriffith Business SchoolFull Tex

    A Capability Model to Understand In-Field Responses to Natural Disaster Relief in the Developing World

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    Humanitarian logistics has grown as a field of research since 2004 through the impact of the Indian Ocean tsunami (Kovács & Spens, 2011). The literature has focused on the increasing costs of natural disasters in terms of the number of casualties among the affected people and the heavy economic losses. These economic losses come at a time when international instability resulting from the Global Financial Crisis (GFC) has led to many nations focusing on their own financial plights. As a result, the level of financial support for international aid has significantly decreased (Dabla-Norris, Minoiu, & Zanna, 2011). Many international humanitarian agencies are finding it more difficult to maintain and retain experienced personnel trained in humanitarian logistics and response to natural disasters (Thomas, 2003; Thomas & Kopczak, 2005). A number of national governments of developing countries are taking more responsibility for managing natural disasters in their own countries, utilising the capacity of their local populations (Kent, 2012). Although local populations are proving to be quite capable, particularly as first responders, they often require technical and financial support to respond effectively to natural disasters (Widmer, 2003).Thesis (PhD Doctorate)Doctor of Philosophy (PhD)Griffith Business SchoolGriffith Business SchoolFull Tex

    Canyons and Ice: The Wilderness Travel of Dick Griffith

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    Dick Griffith journeyed across Alaska, Canada, Mexico, and the American West. According to Jon Krakauer, "Griffith is simply afflicted with an irresistible inclination to attempt what others say can't be done. When asked what possesses a man to repeatedly strike out alone across hundreds of miles of rugged, lonely country, he replies, 'Every so often, it's just time to walk.'" Kaylene Johnson is author of five books about Alaska including her memoir A Tender Distance: Adventures Raising My Son in Alaska

    Prediction of Wave-Induced Seabed Maximum Liquefaction Depth Using Artificial Neural Network Model

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    In the last few decades, considerable effort has been devoted to the phenomenon of wave-induced liquefaction. In deed, it is one of the most important factors used in analysing the seabed stability and in designing marine structures. As waves propagate and fluctuate over the ocean surface, energy is carried within the medium of the water particles. When this energy is transmitted into the seabed, the results are a rather complex mechanism of soil behaviours that significantly affect the stability of the seabed. The prediction of wave-induced seabed liquefaction has been recognised by coastal geotechnical engineers as an important factor when considering the design of marine structures. All existing prediction of wave-induced seabed liquefaction models have been based on conventional approaches of engineering mechanics, with limited laboratory work. Previous studies have involved complicated procedures and complex mathematical methods. The present meticulous study has been based on the existing poro-elastic wave-induced seabed liquefaction solution, and has adopted Artificial Intelligence (AI) technology to predict maximum wave-induced seabed liquefaction. The author has proposed an alternative approach for prediction of the maximum liquefaction depth, based on the Artificial Neural Network (ANN). Unlike previous engineering mechanical approaches, the various proposed ANN models are based on data learning knowledge, rather than on the knowledge of the mechanisms. The author has concluded that ANN models can be applicable to such engineering exercise at least this study.Thesis (PhD Doctorate)Doctor of Philosophy (PhD)Griffith School of EngineeringScience, Environment, Engineering and TechnologyFull Tex

    Breast cancer progression is modulated by inherited genetic variance in multiple independent cohorts

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    Cancer metastasis remains a major health issue and it is the main cause of cancer related mortality, responsible for an estimated 90% of solid tumour related deaths. Further research into the elements that contribute to cancer metastasis is therefore important in identifying key molecular factors and pathways modulating this complex process. This would subsequently enhance the understanding of the metastatic process and facilitate development and deployment of new and improved clinical management for patients with metastatic diseases. Genetic sequence variation is one of the fundamental elements influencing the development of cancer and cancer metastasis. Evidence suggests that inherited genetic variations are one of the essential factors regulating breast cancer metastatic susceptibility; different inbred mouse strains with inherited polymorphisms have wide ranges of transgene-induced mammary tumour metastatic potency, with inherited genetic polymorphisms believed to give rise to a diverse range of metastatic susceptibilities. Molecular analyses, bioinformatics research and literature review have identified a number of potential breast cancer metastasis susceptibility modulating genes. This study extended the research of potential metastasis modulator genes and investigated these genes in human populations, aiming to elucidate the connection of the inherited genetic nature of these potential breast cancer metastasis modulators and breast cancer patients. The hypothesis of this research is that the inherited genetic variance of these putative breast cancer metastasis susceptibility regulating genes, which were identified in previous mouse model research, are predictive of breast cancer patient diagnosis and prognosis. The identification of correlations between inherited genetic variation within novel breast cancer susceptibility genes, and clinical outcome would provide evidence supporting these genes as novel metastasis modulating genes. ABI genotyping assays kits were utilized to perform SNP analysis of potential metastasis modulating gene variants in eight independent population cohorts (mostly Caucasian). This research first screened 49 candidate SNPs from 16 potential metastasis susceptibility modulating genes across two pilot cohorts that were chosen based on mouse model study results. Seven candidate SNPs from four different genes (SIPA1, ARAP3, RRP1B, BRD4) showed association with cancer survival in two pilot cohorts. These SNPs were subsequently assayed in other larger independent cohorts. The results showed that two ARAP3 gene SNPs, rs440279 and rs3763120, were associated with important clinical markers - response to first line chemotherapy and reduced patient survival (with and without stratification of lymph node metastasis status and oestrogen receptor status). Four SIPA1 gene SNPs (SNP rs931127, rs746429, rs2448490 and rs3741378) were also found to be associated with patient outcome; rs746429 (missense SNP) was associated with poor outcome in metastasis-free, disease-free and overall-survival in the largest (Rotterdam, the Netherlands) population. The SNP rs2448490 (intronic SNP) from the same gene was found to be associated with better survival rate in the lymph node metastasis negative/oestrogen receptor positive patients. Since the SIPA1 protein and the RRP1B protein were shown to physically interact with each other and the SIPA1 SNP rs2448490 and RRP1B SNP rs9306160 both showed association with survival in the lymph node metastasis negative/oestrogen receptor positive class of patients; a combined analysis of the SIPA1 SNP rs2448490 and RRP1B SNP rs9306160 was performed, giving the best prognosis in the lymph node metastasis negative/oestrogen receptor positive subgroup. SNPs in the other SIPA1 protein binding partner, BRD4, also showed association with progression-free survival. SNPs from the three genes, SIPA1, RRP1B and BRD4 which are known to be the corner-stone of the Diasporin pathway (Crawford, et al., 2008), a novel pathway in the metastasis process, showed association with breast cancer metastasis and metastasis related survival in multiple independent populations, adding support for these genes as metastasis modulator genes. In addition, the SNP rs3741378 from the SIPA1 gene also showed association with breast cancer incidence, indicating that the SIPA1 gene may not only be a breast cancer metastasis modulating gene but also a breast cancer susceptibility gene. To further investigate the role of this gene in breast cancer, molecular characterisation of an identified Sipa1 protein binding partner, Calmodulin 2, was also undertaken as part of this research. Calm2 was first identified as a potential Sipa1 protein binding partner from yeast two hybrid analysis, (Myriad Genetics, Salt Lake City, UT) with confirmation of binding verified by Coimmunoprecipitation assay. Stable cell lines with up-regulation of Calm2 gene were subsequently created. The stable cell lines were used in in vivo analyses to investigate the possible role of the Calm2 in breast cancer metastasis. However, deriving any firm conclusions from the in vivo analysis of Calm2 can’t be drawn as the control samples of this study didn’t provide adequate data and further investigations of Calm2’s possible role in metastasis are required. These novel metastasis susceptibility modulating genes have previously shown association with breast cancer at the transcriptional and translational level. The results of this study provide evidence that these genes are engaged in human breast cancer survival at the genetic level. The data provide evidence of association between subtle inherited genetic variation of these novel breast cancer metastasis modulators and breast cancer patient outcomes in various independent human populations. The results of this research also provide additional evidence that genetic variation is involved in human breast cancer metastasis and survival. The observation that genetic variation may be an independent indicator for lymph node metastasis, negative/oestrogen receptor positive status, suggests a novel hypothesis in relation to breast cancer biology, ie breast tumours that do and do not colonize to the lymph node system may represent two distinct subtypes of breast cancer, with distinct tumour cell biology and mechanisms of progression.Thesis (PhD Doctorate)Doctor of Philosophy (PhD)School of Medical ScienceGriffith HealthFull Tex

    Will the Emerging India Ever Arrive?

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    This article discusses the ingrained impediments which are likely to stifle India's rise and growth - a phenomenon which has figured prominently in scholarly and official assessments, in India and outside, for over a decade now. Intriguingly India's rise as a global power has already been adjudged a certainty in these assessments, but the author contends that there exists an apparent disjuncture between how the world sees India and the prevailing internal impediments. Therefore, any assessment of India as a global power without incorporating these impediments would be incomplete, misplaced and hyperbolic. Of late, in the light of India's growing internal and external socio-economic and political difficulties, more and more writings and proclamations by Indian and international experts indicate emerging scepticism over India's potential as a global power. This paper takes a rollcall of India's internal impediments including, human development, institutional and security challenges which according to the author have already begun restraining India's global ascent.Full Tex

    Cuban Ceremonial Batá Drumming and YouTube: Understanding Tradition, Change and Video-Sharing in the 21st Century

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    This thesis examines and analyses some key issues related to the emergence of Cuban batá ceremony on YouTube. A musical-religious ceremony related to the Afro-Cuban religion commonly known as Santería, batá ceremony has been part of the YouTube landscape since 2006, although its practice in Cuba dates back to the late 19th century. As a traditional musical-religious practice, its mediation through video, and subsequent dissemination and representation on YouTube, is examined in light of how videography and online video-sharing practices affect the performance and meaning of batá ceremony in the real world, offline environment, as well as examining the way that this new, online representation creates new meaning and understanding of batá performance for those who are involved in its practice. Through examining both the practice of videography at batá ceremony and the production and reception of its online representation on YouTube, I seek to contribute to the growing body of literature that is examining online communities that form around musical practice. This focus on a religious-musical practice also brings into perspective how the effects of modern technological mediation play into traditional religious practices in the modern era, and how this is affecting ceremonial batá drummers and other religious practitioners, those people who arguably have the biggest stake in these new practices. To do this I utilise ethnographic, participantobservation methods in both the offline environment of batá ceremony, and the online environment of YouTube.Thesis (PhD Doctorate)Doctor of Philosophy (PhD)Queensland ConservatoriumArts, Education and LawFull Tex
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