2,526 research outputs found
Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes
No full textBackground and aim: Human atrial transient outward K+ current (ITO) is decreased in a variety of cardiac pathologies, but how ITO reduction alters action potentials (AP) and arrhythmia mechanisms is poorly understood, owing to non-selectivity of ITO blockers.<p></p>
Aim: to investigate effects of selective ITO changes on AP shape and duration (APD), and on afterdepolarisations or abnormal automaticity with beta-adrenergic-stimulation, using the dynamic-clamp technique in atrial cells.<p></p>
Methods and Results: Human and rabbit atrial cells were isolated by enzymatic dissociation, and electrical activity recorded by whole-cell-patch clamp (35-37oC). Dynamic-clamp-simulated ITO reduction or block slowed AP phase 1 and elevated the plateau, significantly prolonging APD, in both species. In human atrial cells, ITO block (100% ITO subtraction) increased APD50 by 31%, APD90 by 17%, and APD-61mV (reflecting cellular effective refractory period) by 22% (P<0.05 for each). Interrupting ITO block at various time points during repolarisation revealed that the APD90 increase resulted mainly from plateau-elevation, rather than from phase 1-slowing or any residual ITO. In rabbit atrial cells, partial ITO block (~40% ITO subtraction) reversibly increased the incidence of cellular arrhythmic depolarisations (CADs; afterdepolarisations and/or abnormal automaticity) in the presence of the beta-agonist isoproterenol (0.1 μM; ISO), from 0% to 64% (P<0.05). ISO-induced CADs were significantly suppressed by dynamic-clamp increase in ITO (~40% ITO addition). ISO+ITO decrease-induced CADs were abolished by beta1-antagonism with atenolol at therapeutic concentration (1 μM).<p></p>
Conclusion. Atrial cell action potential changes from selective ITO modulation, shown for the first time using dynamic-clamp, have the potential to influence reentrant and non-reentrant arrhythmia mechanisms, with implications for both the development and treatment of atrial fibrillation
Bonding InGaAsP/ITO/Si Hybrid Laser With ITO as Cathode and Light-Coupling Material
No full textA 1.5-mu m InGaAsP/ITO/Si hybrid laser with indium tin oxide (ITO) as both a cathode and a light-coupling material is presented. The InGaAsP gain structure with a transparent ITO cathode is flip-chip bonded onto a patterned silicon-on-insulator wafer. The light generated in the InGaAsP multiquantum wells is coupled through the ITO cathode into the Si waveguide to form an InGaAsP/ITO/Si hybrid laser. The threshold current density of this hybrid laser is 20 kA/cm(2) at 210 K. Due to the advantages of post-bonding and simplicity of the fabrication process, such a hybrid laser may be a promising Si light source.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000302534300023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Engineering, Electrical & ElectronicOpticsPhysics, AppliedSCI(E)EI14ARTICLE8712-7142
Letter from Kazuo Ito to Lea Perry, July 15, 1942
No full textTranscript of a letter from Kazuo Ito to Lea Perry. The original letters are housed with the Sonoma County Japanese American Citizens League (JACL), and were borrowed for digitization courtesy of the JACL, December 2014. Digital reproduction of the original item is found in item: ssu_nbea_0010.The North Bay Ethnic Archive features material related to the forced relocation of northern San Francisco Bay Area residents to the Granada (Amache) incarceration camp, Colorado. It includes correspondence, photographs, and reports. Some of the original items are housed with the Sonoma County Japanese American Citizens League (JACL), and were borrowed for digitization courtesy of the JACL. The remainder are housed in Special Collections
Letter from Kazuo Ito to Lea Perry, August 13 1942
No full textTranscript of a letter from Kazuo Ito to Lea Perry. The original letters are housed with the Sonoma County Japanese American Citizens League (JACL), and were borrowed for digitization courtesy of the JACL, December 2014. Digital reproduction of the original item is found in item: ssu_nbea_0012.The North Bay Ethnic Archive features material related to the forced relocation of northern San Francisco Bay Area residents to the Granada (Amache) incarceration camp, Colorado. It includes correspondence, photographs, and reports. Some of the original items are housed with the Sonoma County Japanese American Citizens League (JACL), and were borrowed for digitization courtesy of the JACL. The remainder are housed in Special Collections
Magnetoresistance in triphenyl-diamine derivative blue organic light emitting devices
No full textCopyright 2008 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. This article appeared in Journal of Applied Physics 103, 043706 (2008) and may be found at
Letter from Frank Ito to Joe and Lea Perry, November 2, 1943
No full textTranscript of a letter from Frank Ito to Joe and Lea Perry. The original letters are housed with the Sonoma County Japanese American Citizens League (JACL), and were borrowed for digitization courtesy of the JACL, December 2014. Digital reproduction of the original item is found in item: ssu_nbea_0130.The North Bay Ethnic Archive features material related to the forced relocation of northern San Francisco Bay Area residents to the Granada (Amache) incarceration camp, Colorado. It includes correspondence, photographs, and reports. Some of the original items are housed with the Sonoma County Japanese American Citizens League (JACL), and were borrowed for digitization courtesy of the JACL. The remainder are housed in Special Collections
Structure, properties and proton conductivity of Nafion/[(TiO2)center dot(WO3)(0.148)](psi TiO2) nanocomposite membranes
No full textIn this report are presented the preparation and the characterization of six nanocomposite membranes of formula {Nafion/[(TiO2).(WO3)0.148]yTiO2)} with yTiO2 in the range 0-2.988. These materials are based on Nafion and [(TiO2).(WO3)0.148] nanofiller. The effect of [(TiO2).(WO3)0.148] nanopowders on the structural, thermal, mechanical and electrical properties of {Nafion/[(TiO2).(WO3)0.148]yTiO2} membranes was studied. The water uptake (WU) value of materials was lower than that of pristine Nafion and was correlated with yTiO2. The thermal transitions were investigated by modulated differential scanning calorimetry (MDSC). The mechanical parameters and relaxation processes on temperature were studied by dynamical mechanical analyses (DMA). The FT-IR ATR and mu-Raman vibrational investigations allowed to determine the structure of the hydrophobic polytetrafluoroethylene (PTFE) domains of Nafion and the interactions Nafion-[(TiO2).(WO3)0.148] and Nafion-[H2O] in bulk materials. The analysis of complex conductivity plots were evaluated in the 10-2 Hz-10 MHz and 5-155°C regions. Results indicated that the conductivity of {Nafion/[(TiO2).(WO3)0.148]yTiO2} nanocomposite membrane, with yTiO2 = 1.616, at 135°C, is 5.0 x 10-2 S/cm, while its stability range of conductivity (SRC) extends up to 135°
Supplemental Material - Frequency and impact on clinical outcomes of sarcopenia in patients with idiopathic pulmonary fibrosis
No full textSupplemental Material for Frequency and impact on clinical outcomes of sarcopenia in patients with idiopathic pulmonary fibrosis by Kohei Fujita, Hirotsugu Ohkubo, Akiko Nakano, Yuta Mori, Kensuke Fukumitsu, Satoshi Fukuda, Yoshihiro Kanemitsu, Takehiro Uemura, Tomoko Tajiri, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Yoshiyuki Ozawa, Takayuki Murase and Akio Niimi in Chronic Respiratory Disease</p
Supplemental Material - Decreased peak expiratory flow rate associated with mortality in idiopathic pulmonary fibrosis: A preliminary report
No full textSupplemental Material for Decreased peak expiratory flow rate associated with mortality in idiopathic pulmonary fibrosis: A preliminary report by Kohei Fujita, Hirotsugu Ohkubo, Akiko Nakano, Norihisa Takeda, Kensuke Fukumitsu, Satoshi Fukuda, Yoshihiro Kanemitsu, Takehiro Uemura, Tomoko Tajiri, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Yoshiyuki Ozawa, Takayuki Murase and Akio Niimi in Chronic Respiratory Disease</p
- …
