1,462 research outputs found
Bob Cooke Reminisces
No full textThis video is an oral history interview of J. Robert Cooke by Norman R. Scott and Kenneth M. King on November 10, 2012.0_ax5reiz
Flavilla Reprehending the Intention of the Author While He Explains the Allegory
No full textMedium: stipple engraving and burin"Flavilla Reprehending the Intention of the Author While He Explains the Allegory" [1959.5514.000.000], Williamson, Thomas, Satchwell, R. WilliamArtist and Role: Satchwell, R. William, EngraverArtist and Role: Cooke, Charles, Artist IExtent: plate 15.5 x 9.
Structural, item, and test generalizability of the psychopathology checklist - revised to offenders with intellectual disabilities
No full textThe Psychopathy Checklist–Revised (PCL-R) is the most widely used measure of psychopathy in forensic clinical practice, but the generalizability of the measure to offenders with intellectual disabilities (ID) has not been clearly established. This study examined the structural equivalence and scalar equivalence of the PCL-R in a sample of 185 male offenders with ID in forensic mental health settings, as compared with a sample of 1,212 male prisoners without ID. Three models of the PCL-R’s factor structure were evaluated with confirmatory factor analysis. The 3-factor hierarchical model of psychopathy was found to be a good fit to the ID PCL-R data, whereas neither the 4-factor model nor the traditional 2-factor model fitted. There were no cross-group differences in the factor structure, providing evidence of structural equivalence. However, item response theory analyses indicated metric differences in the ratings of psychopathy symptoms between the ID group and the comparison prisoner group. This finding has potential implications for the interpretation of PCL-R scores obtained with people with ID in forensic psychiatric settings
Tele-operated climbing and mobile service robots for remote inspection and maintenance in nuclear industry
No full textLa industria lítica de Gran Coclé, Panamá, a finales del periodo Cerámico medio. Resultado del análisis de material lítico de la Operación 8 de Sitio Cerro Juan Díaz
No full textBird, J. y R.G. Cooke
1978. “La Cueva de los Ladrones, datos
preliminares sobre la ocupacion formativa”, Actas
del V Simposium Nacional de Antropología Arqueología
y Etnohistoria de Panamá, Panamá, Universidad
de Panamá/Instituto Nacional de Cultura,
pp. 283-305.Bush, M.B. y P.A. Colinvaux
1990. “A pollen record of a complete glacial cycle
from lowland Panama”, Journal of Vegetation Science
1, pp. 105-18.Bush, M. B., D.R. Piperno, P.A. Colinvaux, P.A. P.E. de
Oliveira, L.A. Krissek, M.C. Miller y W.E. Rowe
1992. “A 14,300-yr. paleoecological profile of a
lowland tropical lake in Panama”, Ecological
Monographs, 62, pp. 251-275.Carbonell, E., M. Gilbaud y R. Mora
1982. “Aplicación de la methode dialectique à la
construction d’un systeme analytique pour
l’étude des matériaux du Paléolitique Inférieur”,
Dialektike, 7, pp. 23.Clary, James, P. Hansell, A.J. Ranere, T. Buggey
1984. “The Holocene geology of the western Parita
Bay coastline of central Panama”, en F.W. Lange
(ed.), Recent Developments in Isthmian Archaeology.
British Archaeological Reports, International Series
212, Oxford: B.A.R., pp. 55-83.Cooke, R.G.
1992. “Prehistoric Nearshore and Littoral Fishing
in the Eastern Tropical Pacific: An Ichthyological
Evaluation”, Journal of World Prehistory, 6, p. 1.1998. “Subsistencia y economía casera de los
indígenas precolombinos de Panamá”, en A. Pastor
(coord.), Antropología Panameña: Pueblos y Culturas,
Panamá, Universitaria, pp. 61-134.1999. “The Native People of Central America
during Precolumbian and Colonial Times”, en
Anthony Coates (coord.), Central America, a natural
and cultural history, New Haven y London, Yale
University Press, pp. 137-176.En prensa. “Prehistory of Native Americans on the
Central American Land Bridge: colonization,
dispersal and divergence”.Cooke, G. R. y A. Ranere
1984. “The ‘Proyecto Santa Maria’: a
multidisciplinary analysis of prehistoric
adaptations to a Tropical watershed in Panama”,
en F. Lange (coord.), Recent Developments in Isthmian
Archaeology, Oxford, British Archaeological Reports
International (Series 212), pp. 3-30.1992. “The origin of wealth and hierarchy in the
Central Region of Panama (12,000-2,000BP), with
observations on its relevance to the history and
phylogeny of Chibchan-speaking polities in
Panama and elsewhere”, en F. Lange (coord.),
Wealth and Hierarchy in the Intermediate Area,
Washington, DC, Dumbarton Oaks,
pp. 243-316.1994. “Relación entre recursos pesqueros, geografía
y estrategia de subsistencia en dos sitios
arqueológicos de diferentes edades en un estuario
del pacífico central de Panamá”, Memoria del
Primer Congreso Nacional del Patrimonio
Cultural, Panamá.Cooke, R.G., M. Jiménez, A. Ranere
2002. “Influencias humanas sobre la vegetación y
fauna de vertebrados de Panamá: actualización de
datos arqueozoológicos y su relación con el paisaje
antrópico”, en E. Leigh (coord.), Ecología y
Conservación en Panamá, Panamá, Smithsonian
Tropical Research Institute.Dillehay, T.D.
1989. Monte Verde: A Late Pleistocene Settlement in
Chile, vol. 1, Washington, D.C., Smithsonian
Institution Press.1997. Monte Verde: A Late Pleistocene Settlement in
Chile, vol. 2, Washington, D.C., Smithsonian
Institution Press.Hansell, Patricia
1988. “The Rise and Fall of an Early Formative
Community: La Mula-Sarigua, central Pacific
Panama”, tesis doctoral, Filadelfia, Universidad
de Temple Press.Iltis, H.H.
2000. “Homeotic sexual translocations and the
origin of maize (Zea mays, Poaceae): a new
look at an old problem”, Economic Botany, 54,
pp. 7-42.Jiménez, Máximo
1999. “Explotación de vertebrados acuáticos y
terrestres por los indígenas precolombinos en
Cerro Juan Díaz, Los Santos, durante el Periodo
300-700 d.C.”, tesis de graduación, Escuela de
Biología, Universidad de Panamá, Panamá.Jiménez, M. y R.G. Cooke
2001. “Pesca Precolombina en el Borde de un
Estuario Neotropical: Cerro Juan Díaz (Bahía de
Parita, Costa del Pacífico de Panamá)”, Actas del
39 Congreso de Americanistas, Quito, 1997.Laplace, G.
1974. “De la dynamique de l’Analyse structurale ou
la typologie analythique”, Di Science Prehistoriche,
XXIX, pp. 1-71.Leroi-Gourhan
1988. El hombre y la materia, Madrid, Taurus,
Comunicación.Linné, S.
1929. Darién in the past. The archaeology of eastern
Panama and north-westrn Colombia, Goterborgs
Kungl. Vetensakps och Vitterhets-Samhalles
Handillingar, Femte Foldjen. Goteborg, Elanders
Boktryckeri Aktiebolag (Ser. A. Band 3).Mayo Torné, J.
2004. “La Industria Prehispánica de Conchas
Marinas en Gran Coclé, Panamá”, tesis doctoral,
Departamento de Historia de América II
(Antropología americana), Universidad
Complutense de Madrid.McGimsey III, Ch. R.
1956. “Cerro Mangote. A preceramic site in
Panamá”, American Antiquity, vol. 22, pp. 151-161.McGimsey III, Ch. R., M.B. Collins y T.W. Mckern
1986-1987. “Cerro Mangote and its population”,
Journal of the Steward Anthropological Society, 16 (1 y
2), pp. 125-157.Merino, J. M.
1994. Tipología Lítica, Antropologia-Arkeologia.
Sociedad de Ciencias Aranzadi Zientzi Elkartea,
Suplemento 9, Munibe.Pearson, G.A.
2002. “Pan-Continental Paleoindian Expansions
and Interactions As Viewed from The Earliest
Lithic Industries of Lower Central America”, tesis
doctoral, Departamento de Antropología,
University of Kansas, mecanografiado.Pearson, G.A. y R.G. Cooke
2002. “The Role of the Panamanian Land Bridge
During the Initial Colonization of the Americas”,
Antiquity, 76, pp. 931-932.Piperno, D.R.
1989. “Non-affluent foragers: resource avaliability,
seasonal shortages and the emergence of
agriculture in Panamanian tropical forests”, en
D.R. Harris y G. Hillmanm (coords.), Foraging and
Farming: the Evolution of Plant Domestication,
Londres, Unwin Hymanç, pp. 538-554.1998. “Paleoethnobotany in the Neotropics from
microfossils: new insights into ancient plant use
and agricultural origins in the tropical forest”,
Journal of World Prehistory, 12, pp. 393-449.Piperno, D.R. y D.M. Pearsall
1998. The Origins of Agriculture in the Lowland Tropics,
San Diego, Academic Press.Piperno D.R., M.B. Bush y P.A. Colinvaux
1991. “Paleoecological perspectives on human
adaptation in Panama”, The Pleistocene
Geoarchaeology, 6, pp. 201-26.Piperno, D.R., A.J. Ranere, I. Holst y P. Hansell
2000. “Starch grains reveal early root crop
horticulture in the Panamanian tropical forest”,
Nature, 407, pp. 894-897.Piperno, D.R. y J.G. Jones
2003. “Paleoecological and archaeological
implications of a Late Pleistocene/early Holocene
record of vegetation and colimate chage from the
pacific coastal plain of Panama”, Quaternary
Research, 59, pp. 79-86.Ranere, A.
1973. “Una reinterpretación del precerámico
panameño”, Actas del III Simposium de
Antropología, Arqueología y etnohistoria de
Panamá, Panamá.Ranere, A. y R.G. Cooke
1995. “Evidencias de ocupación humana en
Panamá a postrimerías del Pleistoceno y a
comienzos del Holoceno”, en Cavelier y S. Mora
(eds.), Ámbito y Ocupaciones Tempranas de la América
Tropical, Bogotá, Fundación Erigaie/Instituto
Colombiano de Antropología, pp. 5-26.1996. “Stone Tools and Cultural Boundaries in
Prehistoric Panama”, en F. Lange (ed.), Paths to
Central American Prehistory, Niwot CO, University
Press of Colorado, pp. 49-77.2002. “Late glacial and early Holocene occupation
of Central American tropical forests”, en Julio
Mercader (ed.), Under the Canopy, New Brunswick,
Rutgers University Press, pp. 219-248.Sheets, Payson D., E.J. Rosenthal y A.J. Ranere
1980. “Stone tools from Volcan Barú”, en Linares y
Ranere (eds.), Adaptive Radiations in Prehistoric
Panama, Peabody Museum Monographs 5,
Cambridge, Harvard University Press,
pp. 404-428.Valerio Lobo, W.V.
1987. “Análisis estratigráfico y funcional de
Carabalí (SF-9). Un abrigo rocoso en la Regió
Global intimacy and cultural intoxication: Japanese and South Korean film in the twenty-first century
No full textThis is the author accepted manuscript. The final version is available from Routledge via the link in this record.
Cyclosporin monitoring in Australasia: 2002 update of concensus guidelines
No full textTherapeutic drug monitoring of cyclosporin (CsA) has been established as part of the routine clinical treatment of patients following organ transplantation for more than 20 years, and based on contemporary knowledge, many consensus guidelines have been published to assist clinics and laboratories attain optimal strategies for patient care. This article addresses the newer directions in CsA monitoring, with particular reference to the Australasian situation that has evolved since the 1993 Australasian guideline. These changes have included the introduction of alternative assay methodologies, changed CsA formulation from Sandimmun to Neoral throughout Australasia, and alternatives to trough concentration (C0) monitoring, especially 2-hour concentration (C2) monitoring and associated validated dilution protocols to accurately quantitate the higher whole blood CsA concentrations. The revision was prepared following a recent survey of all Australasian CsA-monitoring laboratories where discordant practices were evident.Morris, Raymond G ; Ilett, Kenneth F ; Tett, Susan E ; Ray, John E ; Fullinfaw, Robert O ; Cooke, Russell ; Cook, Stephe
Human biomarker discovery and predictive models for disease progression for idiopathic pneumonia syndrome following allogeneic stem cell transplantation
No full textAllogeneic hematopoietic stem cell transplantation (SCT) is the only curative therapy for many malignant and nonmalignant conditions. Idiopathic pneumonia syndrome (IPS) is a frequently fatal complication that limits successful outcomes. Preclinical models suggest that IPS represents an immune mediated attack on the lung involving elements of both the adaptive and the innate immune system. However, the etiology of IPS in humans is less well understood. To explore the disease pathway and uncover potential biomarkers of disease, we performed two separate label-free, proteomics experiments defining the plasma protein profiles of allogeneic SCT patients with IPS. Samples obtained from SCT recipients without complications served as controls. The initial discovery study, intended to explore the disease pathway in humans, identified a set of 81 IPS-associated proteins. These data revealed similarities between the known IPS pathways in mice and the condition in humans, in particular in the acute phase response. In addition, pattern recognition pathways were judged to be significant as a function of development of IPS, and from this pathway we chose the lipopolysaccaharide-binding protein (LBP) protein as a candidate molecular diagnostic for IPS, and verified its increase as a function of disease using an ELISA assay. In a separately designed study, we identified protein-based classifiers that could predict, at day 0 of SCT, patients who: 1) progress to IPS and 2) respond to cytokine neutralization therapy. Using cross-validation strategies, we built highly predictive classifier models of both disease progression and therapeutic response. In sum, data generated in this report confirm previous clinical and experimental findings, provide new insights into the pathophysiology of IPS, identify potential molecular classifiers of the condition, and uncover a set of markers potentially of interest for patient stratification as a basis for individualized therapy
Characterization and structure in the development of Tudor comedy
No full textThe role of characterization in dramatic structure is assessed by theoretical criteria.
Characters who perform actions necessary for the completion of the narrative sequence are
said to be "bound" to the narrative; those without such obligations are "free". Characters
who maintain a single, constant meaning during the course of a play are said to be "static";
characters who change or develop into new roles are "dynamic". Horatian decorum
demanded that comic characters be static, and the characters of Plautine and Terentian
tradition were almost always bound to narrative intrigue. However, evaluations of six
Tudor comedies show an increasing use of non-classical characterization within the comic
form.
In the early comedies lohan lohan and Roister Doister all characters are bound and
static, yet the impetus to enlarge the role of characterization is evident. The characters of
lohan lohan are expanded from their French source, and Roister Doister includes
extraneous episodes in which Udall displays his braggart hero. Free characters abound in
Misogonus; as well the play brings dynamic characterization into the scope of comedy with
the conversion of its prodigal son.
Free characters offer new possibilities of non-narrative plotting. In comedies of the
1580s favourite traditional characters appear as diversions outside the action, and thematic
arrangements of characters inform the increasingly complex plots. Lyly stresses the
symbolic potential of characters in Endimion, whereas Greene uses dynamic
characterization to heighten the illusion of independent figures in Friar Bacon and Friar
Bungay. Love's Labour's Lost exposes the limitations of comic artifice by pulling the
characters between convention and individualization.
By the end of the sixteenth century free and dynamic characters had become
common, and characterization had established a sizable claim on the design of English
comedy. These developments set the English form apart from its neoclassical counterparts
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
No full textTesticular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, six loci associated with TGCT have been reported. From genome-wide association study (GWAS) analysis of 307,291 SNPs in 986 TGCT cases and 4,946 controls, we selected for follow-up 694 SNPs, which we genotyped in a further 1,064 TGCT cases and 10,082 controls from the UK. We identified SNPs at nine new loci (1q22, 1q24.1, 3p24.3, 4q24, 5q31.1, 8q13.3, 16q12.1, 17q22 and 21q22.3) showing association with TGCT (P < 5 × 10(-8)), which together account for an additional 4-6% of the familial risk of TGCT. The loci include genes plausibly related to TGCT development. PRDM14, at 8q13.3, is essential for early germ cell specification, and DAZL, at 3p24.3, is required for the regulation of germ cell development. Furthermore, PITX1, at 5q31.1, regulates TERT expression and is the third TGCT-associated locus implicated in telomerase regulation
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