164 research outputs found
sj-docx-1-dhj-10.1177_20552076231220787 - Supplemental material for Increasing trends in online information-seeking and decreasing trends of funded research for polycystic ovary syndrome: An 18-year joinpoint analysis of Google Trends data from 2004 to 2022
No full textSupplemental material, sj-docx-1-dhj-10.1177_20552076231220787 for Increasing trends in online information-seeking and decreasing trends of funded research for polycystic ovary syndrome: An 18-year joinpoint analysis of Google Trends data from 2004 to 2022 by Kashish Malhotra and Punith Kempegowda in DIGITAL HEALTH</p
sj-docx-2-dhj-10.1177_20552076231220787 - Supplemental material for Increasing trends in online information-seeking and decreasing trends of funded research for polycystic ovary syndrome: An 18-year joinpoint analysis of Google Trends data from 2004 to 2022
No full textSupplemental material, sj-docx-2-dhj-10.1177_20552076231220787 for Increasing trends in online information-seeking and decreasing trends of funded research for polycystic ovary syndrome: An 18-year joinpoint analysis of Google Trends data from 2004 to 2022 by Kashish Malhotra and Punith Kempegowda in DIGITAL HEALTH</p
Investigation of the biochemical and clinical phenotype in women with polycystic ovary syndrome
Full text linkObjectives
• Establish the distinct androgen signature in a healthy population
• Investigate whether people with PCOS have a high prevalence of anxiety, depression, and body dysmorphia
• Take steps to include people with PCOS in designing and delivering education regarding the condition can help us reduce the gaps in knowledge, attitude, and practice of PCOS.
Methods
The objectives were addressed in four parts:
• Morning serum and saliva samples were collected from 290 and 83 healthy volunteers respectively. Serum and salivary steroids were quantified by liquid chromatography-tandem mass spectrometry profiling assays (Healthy volunteer study).
• 1006 women completed an online survey which included validated questionnaires on four domains: Emotional wellbeing (anxiety and depression), body image, weight-related stigma, and sexual function (Blue Morpho study).
• 43 women aged 18-60 years were invited to complete an online survey about their lived experiences at the onset of the symptoms of PCOS, their journey during diagnosis, an explanation of PCOS to their younger self, and any advice for their younger self (PCOS Pearls study).
• HCP and people with PCOS underwent simulation-based and workshop-based learning respectively on four PCOS case scenarios. Data regarding confidence and expectations regarding PCOS were collected pre- and post-simulation. Wilcoxon Signed-Rank test was used to compare change in confidence levels. Thematic induction was used to identify areas of gaps between expectation and delivery of care (SIMBA-PCOS study).
Results
Healthy volunteer blood samples confirmed that 11-oxygenated androgens form a stable circulating pool of androgens during adulthood, while classic androgens decline with age and are subject to menstrual cycle-dependent variation. In Blue Morpho study, we found women of non-white ethnicity (611/1003) reported a higher depression (OR 1.96 [95% CI 1.41-2.73]) and lower BDD (OR 0.57 [95% CI 0.41-0.79]) rates, than white ethnic women (392/1003). In PCOS Pearls, we found that people with PCOS were impacted significantly by their symptoms and many women feel dissatisfied with the support they receive from healthcare professionals. In SIMBA PCOS, HCPs reported increased confidence to manage PCOS cases (simulated: +41.0%, p<0.001; non-simulated: +40.0%, p<0.001; all: +40.5%, p<0.001). There was 6.25% (p=0.0141) and 17.7% (p=0.0002) increase in PPI participants’ confidence in HCPs to diagnose and manage PCOS-related issues respectively.
Conclusions
A combination of classic and 11-oxygenated androgens can be used to understand the impact of androgen excess in PCOS. There is a need for tailored, multidisciplinary approach to the management of people with PCOS in the community and improving awareness amongst primary healthcare to improve patient care
Cyanamide
No full text© 2014 Elsevier Inc. All rights reserved. Cyanamide is similar to but not as toxic as cyanide. It is commonly used in agriculture and in pharmaceutical industries. While the main mechanism of acute toxicity is due to overactivity of the parasympathetic nervous system, symptoms of chronic toxicity are due to inhibition of alcohol dehydrogenase resulting in disulfiram-like syndrome. Symptoms of severe poisoning include metabolic acidosis and refractory shock. There is no known antidote for cyanamide toxicity, and management of acute cyanamide toxicity is mainly symptomatic. Chronic toxicity could be prevented by systematic program of medical surveillance of personnel who are under long-term exposure to cyanamide
Appraising Unmet Needs and Misinformation Spread About Polycystic Ovary Syndrome in 85,872 YouTube Comments Over 12 Years: Big Data Infodemiology Study
Full text linkBackgroundPolycystic ovary syndrome (PCOS) is the most common endocrinopathy in women, resulting in substantial burden related to metabolic, reproductive, and psychological complications. While attempts have been made to understand the themes and sentiments of the public regarding PCOS at the local and regional levels, no study has explored worldwide views, mainly due to financial and logistical limitations. YouTube is one of the largest sources of health-related information, where many visitors share their views as questions or comments. These can be used as a surrogate to understand the public’s perceptions.
ObjectiveWe analyzed the comments of all videos related to PCOS published on YouTube from May 2011 to April 2023 and identified trends over time in the comments, their context, associated themes, gender-based differences, and underlying sentiments.
MethodsAfter extracting all the comments using the YouTube application programming interface, we contextually studied the keywords and analyzed gender differences using the Benjamini-Hochberg procedure. We applied a multidimensional approach to analyzing the content via association mining using Mozdeh. We performed network analysis to study associated themes using the Fruchterman-Reingold algorithm and then manually screened the comments for content analysis. The sentiments associated with YouTube comments were analyzed using SentiStrength.
ResultsA total of 85,872 comments from 940 PCOS videos on YouTube were extracted. We identified a specific gender for 13,106 comments. Of these, 1506 were matched to male users (11.5%), and 11,601 comments to female users (88.5%). Keywords including diagnosing PCOS, symptoms of PCOS, pills for PCOS (medication), and pregnancy were significantly associated with female users. Keywords such as herbal treatment, natural treatment, curing PCOS, and online searches were significantly associated with male users. The key themes associated with female users were symptoms of PCOS, positive personal experiences (themes such as helpful and love), negative personal experiences (fatigue and pain), motherhood (infertility and trying to conceive), self-diagnosis, and use of professional terminology detailing their journey. The key themes associated with male users were misinformation regarding the “cure” for PCOS, using natural and herbal remedies to cure PCOS, fake testimonies from spammers selling their courses and consultations, finding treatment for PCOS, and sharing perspectives of female family members. The overall average positive sentiment was 1.6651 (95% CI 1.6593-1.6709), and the average negative sentiment was 1.4742 (95% CI 1.4683-1.4802) with a net positive difference of 0.1909.
ConclusionsThere may be a disparity in views on PCOS between women and men, with the latter associated with non–evidence-based approaches and misinformation. The improving sentiment noticed with YouTube comments may reflect better health care services. Prioritizing and promoting evidence-based care and disseminating pragmatic online coverage is warranted to improve public sentiment and limit misinformation spread
Increasing trends in online information-seeking and decreasing trends of funded research for polycystic ovary syndrome: An 18-year joinpoint analysis of Google Trends data from 2004 to 2022
Full text linkBackground The internet has become the primary source of health-related information, and online health information-seeking behaviour has been used as a reliable surrogate of public awareness. We studied the trends of search interest in polycystic ovary syndrome over time and whether funding for polycystic ovary syndrome research corresponded with the changes in search interest. We also studied the geographic reach of polycystic ovary syndrome interest and whether polycystic ovary syndrome awareness month is an effective strategy to increase polycystic ovary syndrome interest. Methods We performed joinpoint regression on relative search volume data for polycystic ovary syndrome using Google Trends from 2004 to 2022, comparing weekly, monthly and yearly trends. We retrieved the total polycystic ovary syndrome-related articles from 1980 to 2022 to study funded and unfunded literature trends. We did a Mann-Whitney U -test analysis comparing the mean relative search volume during the polycystic ovary syndrome awareness month versus the rest of the weeks yearly. Results Three joinpoints were seen at months 70, 196, and 199 months which were statistically significant when compared to the null hypothesis of zero joinpoints ( p = .0002), one joinpoint ( p = .0002), and two joinpoints ( p = .0395), respectively. The search interest of ‘Polycystic ovary syndrome’ was seen in 195 regions globally. The mean relative search volume in September corresponding to polycystic ovary syndrome awareness month was higher than other months from 2013 to 2022. Of the 41,292 journal articles analysed, there was a positive trend in funded polycystic ovary syndrome research from the 2000s until the onset of the COVID-19 pandemic. Conclusions An increasing polycystic ovary syndrome search interest is probably driven by major legislative and scientific events suggesting the importance of such events. Polycystic ovary syndrome Awareness Month is an effective international awareness initiative to increase online polycystic ovary syndrome information-seeking behaviour. The declining trend in funding is a concern as it mismatches with the continued increase in information-seeking behaviour globally
Glycemic changes in acute anticholinesterase insecticide poisoning
No full textBackground: Patients admitted with acute anticholinesterase poisoning were observed to manifest certain glycemic changes, albeit transient. This study was undertaken to elucidate these changes in detail. Objective: To study the prevalence of any glycemic change in acute anticholinesterase insecticide poisoning and to establish their correlation, if any, with the severity of poisoning. Methods: All patients admitted at our center with a confirmed diagnosis of acute anticholinesterase insecticide poisoning were included in the study. The presence of any glycemic change (hyperglycemia or hypoglycemia or ketosis or glycosuria) was noted and its magnitude and duration were recorded. The presence of any glycemic change was correlated with the severity of poisoning. Results: Of the 76 patients studied, 39 (51%) had consumed organophosphate and 37 (49%) had consumed carbamate. Among the 39 organophosphate poisoning cases, glycosuria alone was observed in 22 cases (56.41%) and along with hyperglycemia in 8 cases. Among the 37 carbamate cases, 14 (37.84%) had glycosuria alone and 5 cases had hyperglycemia in addition. None had hypoglycemia or ketosis. However, the observed glycosuria was transient lasting for a mean of 2.75 days in organophosphate group and 2.25 days in carbamate group. Hyperglycemia lasted slightly longer with a mean duration of 3.25 days and 2.75 days in organophosphate and carbamate poisoning respectively. The glycemic changes observed occurred more frequently in patients with Bardin's grade 2 and 3 poisoning. Conclusion: Transient glycosuria with or without hyperglycemia occurred in a significant number of patients with organophosphate and carbamate poisoning. A positive correlation existed between the glycemic changes and the severity of poisoning. Long term clinical implications of these glycemic changes need to be further evaluated by follow-up studies
Body image concerns in women with polycystic ovary syndrome:A systematic review and meta-analysis
Full text linkObjective: To assess differences in body image concerns among women with and without polycystic ovary syndrome (PCOS).Design: This is a systematic review and meta-analysis.Methods: Electronic databases (MEDLINE, EMBASE, APA PsychInfo, PUBMED, Web-of-Science Core Collection, and Cochrane Controlled Register of Trials [CENTRAL]) were searched from inception through July 2022. Outcome measures included validated questionnaires reporting on body image concerns. Methodological quality was assessed by the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) system, and included studies were assessed for risk of bias. Meta-analyses were performed using the inverse variance method based on random or fixed effects models (Review Manager, Version 5).Results: A total of 918 women with PCOS and 865 women without PCOS from 9 studies were included. Meta-analysis of 3 studies using Multidimensional Body-Self Relations Questionnaire Appearance Scale (MBSRQ-AS) showed those with PCOS reported higher dissatisfaction with appearance evaluation and appearance orientation compared to those without PCOS (mean difference [MD] = −0.78, I2 = 0%, P < .00001, and MD = 0.22, I2 = 54%, P = .004, respectively). Meta-analysis of 2 studies showed higher dissatisfaction with overweight preoccupation, lower body area satisfaction, and body weight classification on MBSRQ-AS subscales in those with PCOS compared to those without PCOS (all P < .001). Meta-analysis of 2 studies using the Body Esteem Scale for Adolescents and Adults (BESAA) showed significantly lower scores for the weight subscale in those with PCOS compared to those without PCOS (P = .03).Conclusions: Those with PCOS experience more significant body image concerns, emphasising the importance of awareness in the clinical care of PCOS. Considering the limited evidence, further studies are warranted to identify drivers and mitigating factors
Foot STAMP (Short-burst Teaching Aimed at Medical Professionals): impact of ‘short-burst' teaching on the knowledge regarding the Ipswich Touch Test
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