1,724,288 research outputs found

    Overcoming EMT-driven therapeutic resistance by BH3 mimetics.

    No full text
    Epithelial-mesenchymal transition (EMT) contributes to the progression of cancer through enhanced invasion and stem-like properties of cancer cells. Additionally, EMT confers resistance towards many chemotherapeutics. We recently described a mechanism that mediates EMT-driven chemoresistance through augmented levels of Bcl-xL, an anti-apoptotic member of the Bcl-2 family (Keitel et al., Oncotarget, in press). Here, we elaborate on how these findings pertain to cancer cells dispersed in the tumor-adjacent stroma of breast cancer tissues, and how BH3-mimetics may provide a therapeutic strategy to eliminate cancer cell populations that have passed through an EMT

    Overcoming EMT-driven therapeutic resistance by BH3 mimetics.

    No full text
    Epithelial-mesenchymal transition (EMT) contributes to the progression of cancer through enhanced invasion and stem-like properties of cancer cells. Additionally, EMT confers resistance towards many chemotherapeutics. We recently described a mechanism that mediates EMT-driven chemoresistance through augmented levels of Bcl-xL, an anti-apoptotic member of the Bcl-2 family (Keitel et al., Oncotarget, in press). Here, we elaborate on how these findings pertain to cancer cells dispersed in the tumor-adjacent stroma of breast cancer tissues, and how BH3-mimetics may provide a therapeutic strategy to eliminate cancer cell populations that have passed through an EMT

    Leucippo : pastorale per musica

    No full text
    Autopsie nach Ex. der ULB Sachsen-AnhaltLeucippoVorlageform des Erscheinungsvermerks: Gedruckt mit Keitelschen Schriften. - Erscheinungsjahr nach Wirkunszeit des Komponisten geschätz

    De vita moribus meritis et scriptis Hieronymi Mercurialis Foroliviensis commentatio

    No full text
    Die Vorlage enth. insgesamt 3 WerkeAutopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Brvnsviogae Stanno Keiteliano A. MDCCLI

    Alemania necesita una industria fuerte: "tesis para una salida de la crisis en una Economia Social de Mercado"

    No full text
    "Alemania debe continuar siendo un país industrial. Debemos volver a lo que ha sido nuestra fortaleza" dijo Hans-Peter Keitel, Presidente de la Confederación Federal de la Industria alemana (BDI) en el Foro\ud Político Ruhr el 18 de enero del 2010 en Essen. "La crisis ha mostrado más que evidentemente, que no es dañoso y que es todo lo contrario a lo que podría considerarse poco moderno, producir cosas que\ud tengan un auténtico valor", subrayó Keitel

    Reformen des Mathematikunterrichts in den USA: Geschichte, Reformkonzeptionen und Curriculumentwicklung

    No full text
    Keitel-Kreidt C. Reformen des Mathematikunterrichts in den USA: Geschichte, Reformkonzeptionen und Curriculumentwicklung. Bielefeld; 1982
    corecore