1,089 research outputs found
Effect of pre-<i>in vitro</i> maturation with cAMP modulators on the acquisition of oocyte developmental competence in cattle
No full textThe administration of follicle-stimulating hormone (FSH) prior to oocyte retrieval improves oocyte developmental competence. During bovine embryo production in vitro, however, oocytes are typically derived from FSH-unprimed animals. In the current study, we examined the effect of pre-in vitro maturation (IVM) with cAMP modulators, also known as the second messengers of FSH, on the developmental competence of oocytes derived from small antral follicles (2–4 mm) of FSH-unprimed animals. Pre-IVM with N6,2ʹ-O-dibutyryladenosine 3′,5′-cyclicmonophosphate (dbcAMP) and 3-isobutyl-1-methylxanthine (IBMX) for 2 h improved the blastocyst formation in oocytes stimulated by FSH or amphiregulin (AREG). Furthermore, pre-IVM enhanced the expression of the FSH-or AREG-stimulated extracellular matrix-related genes HAS2, TNFAIP6, and PTGS2, and epidermal growth factor (EGF)-like peptide-related genes AREG and EREG. Additionally, pre-IVM with dbcAMP and IBMX enhanced the expression of EGFR, and also increased and prolonged cumulus cell-oocyte gap junctional communication. The improved oocyte development observed using the pre-IVM protocol was ablated by an EGF receptor phosphorylation inhibitor. These results indicate that pre-IVM with cAMP modulators could contribute to the acquisition of developmental competence by bovine oocytes from small antral follicles through the modulation of EGF receptor signaling and oocyte-cumulus/cumulus-cumulus gap junctional communication. © 2018 by the Society for Reproduction and Development
Correction: Corrigendum: The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells
No full textScientific Reports 7: Article number: 42845; published online: 20 February 2017; updated: 22 December 2017. The original version of this Article contained an error in the spelling of the author Yuuki Imai, which was incorrectly given as Yu-ki Imai. This error has now been corrected in the PDF and HTML versions of the Article, and in the accompanying Supplementary Information.</jats:p
Minedition
No full textThis is a lovely book I happened to find when I was trying to spend down the little money left on my Eurocheck debit card in the late days of my stay in Mannheim. The book is unusual in opening not from right to left but from down to up; that is, one needs to hold it sideways and lift the cover. The cover picture shows the half-painted jackdaw as he returns after opening his craw and being recognized by the doves whose food he was eating. Why does his fellow jackdaw have various colored feathers protruding from his black body and even one such feather in his beak? The pearl that the rooster finds in CJ is part of a ring. The little goat dancing for the wolf uses a hula-hoop! The expanding frog in OF is about to reach the ceiling of a modernistic garden-house! He is elevated off the floor like a helium-filled balloon. The one illustration for FS includes both the plate for the stork and the vase for the fox. In fact, the wall behind the stork features several plates and the floor behind the fox shows three large vases with steam bubbles emerging from them. The resting hare in TH has a hammock slung across the trail. The dropped meat bubbles through the text, dividing its lines in DS. The grapes break down through the ceiling of the fox's room in FG as clouds blow through the windows. The city mouse is fishing in the soup at the city meal in TMCM! A highway--or a racetrack?--winds among cheese wedges and salt and pepper shakers in this fable's tailpiece. The rack of the stag in the pool reaches out like a tree and even includes a birdhouse! What lovely imaginative work! The book is, as regularly with Neugebauer, beautifully produced.This is a hardbound book (hard cover)Language note: GermanNacherzählt von Renate Raeck
伝統的建造物群保存地区におけるイベント型観光の可能性 －橿原市今井町の事例－
No full textMany important preservation districts of groups of historic buildings have developed as tourist destinations in Japan. But Imai-cho in the City of Kashihara - one of the most famous historical districts in Japan - is situated as residential zone in Kasihara city planning and previous studies said that residents in Imai-cho did not want to develop their district as a normal tourist destination. Therefore, this article aims to examine the possibility of developing an event tourism in the Imai-cho. Events opened on each Saturday and Sunday in November in 2009. Many events, such as concerts, lectures, bar and so forth opened from Saturday afternoon to Sunday afternoon. In these events, some tourists stayed at historical buildings. The author examines the assessments of these events by the questionnaire to tourists and residents in the Imai-cho. There are many tourist attractions such as public open spaces, museums and important cultural properties in the Imai-cho. But souvenir shops and eating and drinking places are not plenty for tourists and there is no main shopping street in the Imai-cho. Most of tourists lived within Kinki region. They usually went to other destinations after they stayed in the Imai-cho during only few hours. They hoped the Imai-cho will develop as historical tourist destination. But some tourists and residents hoped the Imai-cho not to develop as a normal tourist destination. They hoped to develop the event tourism in the Imai-cho in order to preserve life of residents.departmental bulletin pape
2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement
No full textCollaborators: Lucas Aparicio (Argentina), Kei Asayama (Japan), Roland Asmar (France), Grzegorz Bilo (Italy), Jean-Marc Boivin (France), Alejandro de la Sierra (Spain), Eamon Dolan (Ireland), Jan Filipovsky (Czech Republic), Geoffrey Head (Australia), Yutaka Imai (Japan), Kazuomi Kario (Japan), Anastasios Kollias (Greece), Efstathios Manios (Greece), Klaus Matthias (Germany), Richard McManus (UK), Anastasia Mihailidou (Australia), Paul Muntner (USA), Martin Myers (Canada), Teemu Niiranen (Finland), Angeliki Ntineri (Greece), Takayoshi Ohkubo (Japan), Aleksander Prejbisz (Poland), Athanase Protogerou (Greece), Menno Pruijm (Switzerland), Aletta Schutte (Australia), Daichi Shimbo (USA), Joseph Schwartz (USA), James Sharman (Australia), Andrew Shennan (UK), Jan Staessen (Belgium), Markus van der Giet (Germany), Liffert Vogt (The Netherlands), Jiguang Wang (China), Paul Whelton (USA), William White (USA)
タイポロジー・プロジェクト : 研究者目線で支援サービスを継続するためのプロジェクト
No full textRA協議会第2回年次大会(福井)開催日時: 2016年9月1日(木)-2016年9月2日(金)開催場所: AOSSA 5F, 6F(福井市地域交流プラザ), AOSSA 8F(福井県県民ホール)主催: リサーチ・アドミニストレーター協議
Environmental and Physiological Influences on Human Natural Killer Cell Activity in Relation to Good Health Practices
No full textVoucher privatization with investment funds : an institutional analysis
No full textCommon wisdom among post-socialist reformers has beento use voucher investment funds to provide the corporate governance needed to restructure newly privatized enterprises after mass privatization efforts. The idea has been that mass privatization would spread the ownership too wide and make corporate governance difficult. The author examines the likely institutional behavior of voucher funds and the possible effects of their development on a transition economy. Since most policy advice has been in favor of voucher privatization with investment funds, the author can be seen as playing the devil's advocate, but his argument is institutional, not statistical. Policymaking requires insight and foresight into how institutions will tend to function. He concludes that voucher funds will introduce a bias in the economy away from the real industrial sector toward an ersatz"financial sector"that will have little if any positive financial role but will be well-protected by friendly regulators. One long-term consequence of voucher privatization with investment funds, according to this view, is a de facto"industrial policy"of real sector decapitalization in favor of short-term rent-seeking by fund managers through board sinecures and lucrative side deals with portfolio companies and through financial market manipulation and paper entrepreneurship in the"financial sector."Without strong corporate governance from the funds and without stable ownership of their own, many enterprise managers will exploit the post-socialist version of the"separation of ownership and control"to grab what they can in the form of salaries, bonuses, perquisites, and side deals. The most likely results of the strategy of voucher privatization with investment funds may be a two-sided grab fest by fund managers and enterprise managers -- together with the accompanying drift, stagnation, and decapitalization of the privatized industrial sector.Economic Adjustment and Lending,Payment Systems&Infrastructure,International Terrorism&Counterterrorism,Economic Theory&Research,Banks&Banking Reform,International Terrorism&Counterterrorism,Banks&Banking Reform,Economic Adjustment and Lending,Environmental Economics&Policies,Economic Theory&Research
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