26 research outputs found
Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction
No full textAbnormal lung inflammation and oxidant burden are associated with a significant reduction in histone deacetylase 2 (HDAC2) abundance and steroid resistance. We hypothesized that Nrf2 regulates steroid sensitivity via HDAC2 in response to inflammation in mouse lung. Furthermore, HDAC2 deficiency leads to steroid resistance in attenuating lung inflammatory response, which may be due to oxidant/antioxidant imbalance. Loss of antioxidant transcription factor Nrf2 resulted in decreased HDAC2 level in lung, and increased inflammatory lung response which was not reversed by steroid. Thus, steroid resistance or inability of steroids to control lung inflammatory response is dependent on Nrf2-HDAC2 axis. These findings have implications in steroid resistance, particularly during the conditions of oxidative stress when the lungs are more susceptible to inflammatory response, which is seen in patients with chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, and inflammatory bowel disease
Psychologický rozměr africké migrace v Evropě
No full textEuropean Politics and Society: Václav Havel Joint Master Programme CHARLES UNIVERSITY FACULTY OF SOCIAL SCIENCES Institute of International Studies Department of European Studies Master's Thesis 2023 Yinka Adenuga European Politics and Society: Václav Havel Joint Master Programme CHARLES UNIVERSITY FACULTY OF SOCIAL SCIENCES Institute of International Studies Department of European Studies DETERMINANT OF MIGRATION AMONG AFRICANS IN THE CZECH REPUBLIC Master's Thesis Author: Yinka Azeez Adenuga, 48318753 (CUNI) Supervisor: PhDr. Barbora Menclová, Ph.D. Year of the Defence: 2023 ABSTRACT This study deals with African migrants in the Czech Republic. Given the absence of general knowledge about African migrants in the Czech Republic, it contributes to the knowledge production of African migrants by examining the general features of their composition and structures in the Czech Republic. More primarily, this study deals with the motivation for migration among Africans who chose the Czech Republic as their destination. Understanding the determinants of African migration in the Czech Republic remains poor and insufficient, as there is little empirical study that has specifically examined the determinants of migration among Africans in the Czech Republic. As a result, this study is a novel study that aims to...Katedra evropských studiíDepartment of European StudiesFaculty of Social SciencesFakulta sociálních vě
Determinant of Migration Among Africans in the Czech Republic
No full textEuropean Politics and Society: Václav Havel Joint Master Programme CHARLES UNIVERSITY FACULTY OF SOCIAL SCIENCES Institute of International Studies Department of European Studies Master's Thesis 2023 Yinka Adenuga European Politics and Society: Václav Havel Joint Master Programme CHARLES UNIVERSITY FACULTY OF SOCIAL SCIENCES Institute of International Studies Department of European Studies DETERMINANT OF MIGRATION AMONG AFRICANS IN THE CZECH REPUBLIC Master's Thesis Author: Yinka Azeez Adenuga, 48318753 (CUNI) Supervisor: PhDr. Barbora Menclová, Ph.D. Year of the Defence: 2023 ABSTRACT This study deals with African migrants in the Czech Republic. Given the absence of general knowledge about African migrants in the Czech Republic, it contributes to the knowledge production of African migrants by examining the general features of their composition and structures in the Czech Republic. More primarily, this study deals with the motivation for migration among Africans who chose the Czech Republic as their destination. Understanding the determinants of African migration in the Czech Republic remains poor and insufficient, as there is little empirical study that has specifically examined the determinants of migration among Africans in the Czech Republic. As a result, this study is a novel study that aims to..
TEACHING CURRENCY: LEVERAGING ON PROSPECTS AND CHALLENGES OF THE 4TH INDUSTRIAL REVOLUTION (INDUSTRY 4.0) IN THE COLLEGES OF TECHNOLOGY IN UNITED KINGDOM
No full textTechnical Support: Towards Mitigating Effects of Computer Anxiety on Acceptance of E-Assessment Amongst University Students in Sub Saharan African Countries
No full textPart 1: Technology Adoption, Diffusion and Ubiquitous ComputingInternational audienceThe application of Information technology in educational context and environment has dramatically changed the pattern at which people teach and learn. Institutions of higher learning globally are increasingly adopting e-Assessment as a replacement for traditional pen on paper examination due to its cost effectiveness, improved reliability due to machine marking, accurate and timely assessment. In spite of the numerous benefits of e-assessment, it is unclear if University students in Sub Saharan African Countries are willing to accept it. The purpose of this study is to examine technical support role towards mitigating effects of computer anxiety on electronic assessment amongst University students in Nigeria and Cameroon. Therefore, the study extended Technology Acceptance Model and was validated using 102 responses collected randomly across universities in Nigeria and Cameroon. This study supports the body of knowledge by establishing that Computer Anxiety is an important factor which can affect University students regardless of their level of computer proficiency. The outcome of the proposed model indicated that when technical assistance is provided during e-Assessment, computer anxiety on majority of University students in Nigeria and Cameroon is reduced. The practical implication of this study is that students’ actual academic potentials may not be seen if education policy makers and University administrators do not always strive to ensure that all measures, including technical support that can reduce fear associated with use of computer for assessment, are introduced
FACTORS RESPONSIBLE FOR EARLY PREGNANCY AMONG FEMALE TEENAGERS IN ESURE, AKURE SOUTH LOCAL GOVERNMENT AREA, ONDO STATE
No full textThis is an international scientific conference research paper presentation on the factors responsible for teenage pregnancies in the community.Teenage pregnancy has recently gained popularity due to its numerous negative effects on the overall health of the adolescent nursing mother, the child, the family, and the entire community. The study investigated factors responsible for early pregnancy among female teenagers in Esure, Akure South Local Government, Ondo State, Nigeria. The study employed a descriptive design, administering 108 questionnaires for analysis using IBM SPSS Version 25. The findings revealed that 92.6% of the respondents are knowledgeable about teenage pregnancy; 86% have given birth; age at first sexual intercourse was highest between 17 19 years (44%); Primary causes of teenage pregnancy include a lack of sex education (70%), followed by peer pressure (35%), poverty (20%), and low self-esteem (19%). Other associated factors include a lack of self-control (28%), a lack of parenting (24%), and poverty (23%). The vulnerable groups include orphans (82.4%), children from single parents (74%), sexually active teenagers (92.6%), and gifts from the opposite sex (83.3%). The implications of teenage pregnancy include sexually transmitted infections (40%), abortion (23%), bleeding after birth (15%), death (14%), and infertility (8%). Other factors include school dropout (35.2%) and stigmatisation (34.3%). Prevention of teenage pregnancy includes health education (33.3%), abstinence (22.2%), use of contraceptives (18.5%), prevention of early marriage (9.3%), sex education (8.3%). The study recommends the introduction of youth-friendly health services, continuous health education, and the incorporation of human sexuality education into school curricula. The study also advocates for government support in establishing youth counselling centres and providing resources for pregnant and parenting teenagers.N/
Supply chain decision-making using artificial intelligence and data analytics
No full textoai:alma.44UOBO_INST:114026730008841This chapter examines the use of artificial intelligence, data analytics and other digital technologies in the management of the supply chain decision-making. The study highlights the challenges faced by supply chain managers and how the application of AI and data analytics can help in making better and more informed decisions with respect to sustainability. Data analytics, AI techniques, such as machine learning, natural language processing and other digital technologies that include Internet of Things, Robotics and Cloud computing and their applications to different areas of supply chain management, such as demand forecasting, inventory management and logistics optimisation are discussed. Some of the challenges (initial cost of physical and cloud resources, change management, ethical and legal-related issues) that the supply chain managers need to put into consideration when adopting these technologies are also presented. The chapter concludes that continuous data collection and storage across all the stakeholders in the supply chain must be ensured to enable transparent and efficient use of AI algorithms to support quick and timely supply chain decision-making
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease
No full textChronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators. A better understanding of the pathobiology of COPD is critical for the development of novel therapies. In the present review, we have discussed the roles of oxidative/aldehyde stress, inflammation/immunity, and chromatin remodeling in the pathogenesis of COPD. An imbalance of oxidants/antioxidants caused by cigarette smoke and other pollutants/biomass fuels plays an important role in the pathogenesis of COPD by regulating redox-sensitive transcription factors (e.g., NF-κB), autophagy and unfolded protein response leading to chronic lung inflammatory response. Cigarette smoke also activates canonical/alternative NF-κB pathways and their upstream kinases leading to sustained inflammatory response in lungs. Recently, epigenetic regulation has been shown to be critical for the development of COPD because the expression/activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in airways of COPD patients. Hence, the significant advances made in understanding the pathophysiology of COPD as described herein will identify novel therapeutic targets for intervention in COPD
Towards reinforcing telemedicine adoption amongst clinicians in Nigeria
No full textTelemedicine systems have been considered as a necessary measure to alleviate the shortfall in skilled medical specialists in developing countries. However, the obvious challenge is whether clinicians are willing to use this technological innovation, which has aided medical practice globally. One factor which has received little academic attention is the provision of suitable encouragement for clinicians to adopt telemedicine, in the form of rewards, motivation or incentives. A further consideration for telemedicine usage in developing countries, especially sub-Saharan Africa and Nigeria in particular, are to the severe shortage of available practising clinicians. The researchers therefore explore the need to positively reinforce the adoption of telemedicine amongst clinicians in Nigeria, and also offer a rationale for this using the UTAUT model. Data were collected using a structured paper-based questionnaire, with 252 physicians and nurses from six government hospitals in Ondo state, Nigeria. The study applied SmartPLS 2.0 for analysis to determine the relationship between six variables. Demographic moderating variables, age, gender and profession, were included. The results indicate that performance expectancy (p < 0.05), effort expectancy (p < 0.05), facilitating condition (p < 0.01) and reinforcement factor (p < 0.001) have significant effects on clinicians’ behavioural intention to use telemedicine systems, as predicted using the extended UTAUT model. Our results showed that the use of telemedicine by clinicians in the Nigerian context is perceived as a dual responsibility which requires suitable reinforcement. In addition, performance expectancy, effort expectancy, facilitating condition and reinforcement determinants are influential factors in the use of telemedicine services for remote-patient clinical diagnosis and management by the Nigerian clinician
