1,423 research outputs found
Phosphorylation of NS5A Serine-235 is essential to hepatitis C virus RNA replication and normal replication compartment formation
No full textData source: Appendix A: supplementary material, http://www.sciencedirect.com/science/article/pii/S0042682216000210#appd002Abstract not availableNicholas S. Eyre, Rachel J. Hampton-Smith, Amanda L. Aloia, James S. Eddes, Kaylene J. Simpson, Peter Hoffmann, Michael R. Bear
Systematic screening identifies dual PI3K and mTOR Inhibition as a conserved therapeutic vulnerability in osteosarcoma
No full textDisclosure of Potential Conflicts of Interest J. Desai is a consultant/advisory board member for GlaxoSmithKline, Novartis, and Roche. No potential conflicts of interest were disclosed by the other authors.Abstract not availableAnkita Gupte, Emma K. Baker, Soo-San Wan, Elizabeth Stewart, Amos Loh, Anang A. Shelat, Cathryn M. Gould, Alistair M. Chalk, Scott Taylor, Kurt Lackovic, Åsa Karlstr, om, Anthony J. Mutsaers, Jayesh Desai, Piyush B. Madhamshettiwar, Andrew C.W. Zannettino, Chris Burns, David C.S. Huang, Michael A. Dyer, Kaylene J. Simpson, and Carl R.Walkle
Homer Simpson Ponders Politics: Popular Culture as Political Theory
Get PDFIt is often said that the poet Homer “educated” ancient Greece. Joseph J. Foy and Timothy M. Dale have assembled a team of notable scholars who argue, quite persuasively, that Homer Simpson and his ilk are educating America and offering insights into the social order and the human condition.
Following Homer Simpson Goes to Washington (winner of the John G. Cawelti Award for Best Textbook or Primer on American and Popular Culture) and Homer Simpson Marches on Washington, this exceptional volume reveals how books like J. R. R. Tolkien’s The Hobbit and J. K. Rowling’s Harry Potter, movies like Avatar and Star Wars, and television shows like The Office and Firefly define Americans’ perceptions of society. The authors expand the discussion to explore the ways in which political theories play out in popular culture.
Homer Simpson Ponders Politics includes a foreword by fantasy author Margaret Weis (coauthor/creator of the Dragonlance novels and game world) and is divided according to eras and themes in political thought: The first section explores civic virtue, applying the work of Plato and Aristotle to modern media. Part 2 draws on the philosophy of Hobbes, Locke, Rousseau, and Smith as a framework for understanding the role of the state. Part 3 explores the work of theorists such as Kant and Marx, and the final section investigates the ways in which movies and newer forms of electronic media either support or challenge the underlying assumptions of the democratic order. The result is an engaging read for undergraduate students as well as anyone interested in popular culture.
Joseph J. Foy, associate campus dean and associate professor of political science at the University of Wisconsin–Waukesha, is the editor of Homer Simpson Goes to Washington: American Politics through Popular Culture and coeditor of Homer Simpson Marches on Washington: Dissent through American Popular Culture.
Timothy M. Dale, assistant professor of political science at the University of Wisconsin–La Crosse, is coeditor of Homer Simpson Marches on Washington: Dissent through American Popular Culture.
“Today, film, fiction, and television reflect our notions of civic virtue, morality, and the human condition—or at least help us to struggle with understanding and defining these. The ubiquitous nature of popular culture means that it will have an effect upon us, whether one likes that or not. The authors argue that, given this fact, even those who doubt the ‘seriousness’ of popular culture would do well to pay attention to it.”—Margaret Ferguson, Assistant Vice President for Statewide Academic Relations at Indiana University
Since ancient times myths and stories have been used to convey our deepest thoughts about how to live together in community. With this book we now have a fun and engaging way to learn and think about political theory through the myths and stories of our time, popular culture. -- William Irwin, author of Black Sabbath and Philosophy: Mastering Reality
Foy and Dale have done it again, this time with political theory! Political theory is one of the most difficult subjects that political science undergraduates encounter and Homer Simpson Ponders Politics opens up an avenue for students to engage many of the broad theories through some of the cultural artifacts with which they are most familiar: popular culture. These important theories bubble up through all areas of popular culture from Machiavelli and The Godfather to Plato and Star Wars— there is much to learn from this compendium. This is a useful book for students of political theory of any age or training and for those who are intrigued by the many political concepts popular culture teaches us. --Lilly J. Goren, coeditor of Women and the White House: Gender, Popular Culture, and Presidential Politics
Most essays in this collection employ their philosophical guides in ways that can...disabuse undergraduates of the notion that political theory can better address the sterile and obsolete concerns of forgotten eras than fundamental questions about contemporary political life. -- Choicehttps://uknowledge.uky.edu/upk_american_popular_culture/1013/thumbnail.jp
Strategies and challenges for systematically mapping biologically significant molecular pathways regulating carcinoma epithelial-mesenchymal transition
No full textEnormous progress has been made towards understanding the role of specific factors in the process of epithelial-mesenchymal transition (EMT); however, the complex underlying pathways and the transient nature of the transition continues to present significant challenges. Targeting tumour cell plasticity underpinning EMT is an attractive strategy to combat metastasis. Global gene expression profiling and high-content analyses are among the strategies employed to identify novel EMT regulators. In this review, we highlight several approaches to systematically interrogate key pathways involved in EMT, with particular emphasis on the features of multiparametric, high-content imaging screening strategies that lend themselves to the systematic discovery of highly significant modulators of tumour cell plasticity
Vacancy generation resulting from electrical deactivation of arsenic
No full textElectrical deactivation of arsenic in highly doped silicon has been studied using the positron-beam technique. Direct experimental evidence linking the formation of arsenic-vacancy complexes (i.e., As-n-v) to the deactivation process is reported. The average number of arsenic atoms per complex, (n) over bar>2, was determined by comparing the observed complex concentrations with those of the deactivated arsenic inferred from Hall-effect measurements. (C) 1995 American Institute of Physics.PT: J; CR: AERS GC, 1991, POSITRON BEAMS SOLIE, P162 ALATALO M, 1995, PHYS REV B, V51, P4176 CHU WK, 1980, LASER SOLID INTERACT, P253 DANNEFAER S, 1987, PHYS STATUS SOLIDI A, V102, P481 DLUBEK G, 1987, PHYS STATUS SOLIDI A, V102, P443 FAHEY PM, 1989, REV MOD PHYS, V61, P289 GOETZLICH J, 1985, ION BEAN PROCESSES A, P349 GOLDBERG RD, 1995, APPL SURF SCI, V85, P287 JACKMAN TE, 1989, APPL PHYS A-SOLID, V49, P335 LIETOILA A, 1981, J APPL PHYS, V52, P230 LIETOLA A, 1980, APPL PHYS LETT, V36, P675 LUNING S, 1992, IEDM, P349 LYNN KG, 1979, PHYS REV B, V20, P3566 PANDEY KC, 1988, PHYS REV LETT, V61, P1282 ROUSSEAU PM, 1994, APPL PHYS LETT, V65, P578 SCHULTZ PJ, 1988, NUCL INSTRUM METH B, V30, P94 SCHULTZ PJ, 1988, REV MOD PHYS, V60, P701 SIMPSON PJ, UNPUB; NR: 18; TC: 38; J9: APPL PHYS LETT; PG: 3; GA: TJ304Source type: Electronic(1
Positron beam study of annealed silicon nitride films
No full textPositron annihilation spectroscopy has been used to study silicon nitride films grown by plasma-enhanced chemical vapor deposition and annealed at different temperatures. For both silicon-rich and nitrogen-rich films, the positron line shape (S) parameter increases after annealing for 15 min at temperatures up to 700-800 degrees C. This is understood in terms of the fact that removal of the hydrogen by annealing leads to the presence of unpassivated silicon dangling bond sites and vacancy complexes. Annealing at higher temperatures leads to a reduction in the S parameter, consistent with further hydrogen removal producing unpassivated N- sites. (C) 1996 American Institute of Physics.PT: J; CR: ASOKAKUMAR P, 1994, J APPL PHYS, V76, P4935 GOLDBERG RD, 1995, APPL SURF SCI, V85, P287 GOSSMANN HJ, 1992, APPL PHYS LETT, V61, P540 HABRAKEN FHP, 1991, LPCVD SILICON NITRID, P118 HAKVOORT RA, 1991, APPL PHYS LETT, V59, P1687 HAKVOORT RA, 1993, THESIS DELFT U TECHN HEYNS M, 1991, LPCVD SILICON NITRID, P82 LANDFORD WA, 1978, J APPL PHYS, V49, P2473 LANDFORD WA, 1992, NUCL INSTRUM METH B, V66, P65 LANDHEER D, 1995, J APPL PHYS, V78, P2568 LU Z, 1995, J VAC SCI TECHNOL 1, V13, P607 LYNN KG, 1989, CAN J PHYS, V67, P618 MITCHELL LV, 1990, AIP C P, V218, P121 PEROVIC DD, 1991, PHYS REV B, V43, P14257 RUBLOFF GW, 1990, VACUUM, V41, P790 SCHULTZ PJ, 1988, NUCL INSTRUM METH B, V30, P94 SCHULTZ PJ, 1988, PHYS REV LETT, V61, P187 SCHULTZ PJ, 1988, REV MOD PHYS, V60, P701 SIMPSON PJ, 1991, PHYS REV B, V44, P12180 SMITH DL, 1990, J ELECTROCHEM SOC, V137, P614 SMITH DL, 1990, MATER RES SOC S P, V165, P69; NR: 21; TC: 1; J9: J APPL PHYS; PG: 5; GA: TY119Source type: Electronic(1
Variable-energy positron beam study of arsenic diffusion in poly-silicon
No full textThe positron beam technique is shown to be a sensitive indicator of the presence of arsenic within the grain boundaries of poly-silicon. Variable-energy positron beam and secondary-ion mass spectrometry studies have been performed on As+-implanted pre-amorphized Si samples as a function of dose and rapid thermal anneal temperature. Positron trapping within negatively-charged grain boundaries of the recrystallized poly-Si is observed, resulting in a similar to 2% elevation in the Doppler-broadening S lineshape parameter value. Infusion of As+-ions into the grain boundaries passivates the charge and reduces their specific positron-trapping rate.PT: J; CR: AERS GC, 1991, POSITRON BEAMS SOLIE, P162 ASOKAKUMAR P, 1993, NUCL INSTRUM METH B, V74, P89 BOUSETTA A, 1991, NUCL INSTRUM METH B, V55, P565 DANNEFAER S, 1987, PHYS STATUS SOLIDI A, V102, P481 DANNEFAER S, 1989, J APPL PHYS, V66, P3526 DLUBEK G, 1987, PHYS STATUS SOLIDI A, V102, P443 FLYNN CP, 1992, POINT DEFECTS DIFFUS GANIN E, 1989, APPL PHYS LETT, V54, P2127 HAKVOORT RA, 1992, MATER SCI FORUM, V105, P1391 HAKVOORT RA, 1993, THESIS DELFT U TECHN JACKMAN TE, 1989, APPL PHYS A-SOLID, V49, P335 KALISH R, 1984, APPL PHYS LETT, V44, P107 KEINONEN J, 1988, PHYS REV B, V37, P8269 LEO PH, 1981, PHYS STATUS SOLIDI B, V108, K145 LOMBARDO S, 1994, J APPL PHYS, V75, P345 MAKINEN J, 1990, J APPL PHYS, V67, P990 MITCHELL IV, 1991, POSITRON BEAMS SOLID, P121 NASU H, 1987, YOGYO-KYOKAI-SHI, V95, P5 NIELSEN B, 1987, APPL PHYS LETT, V51, P1022 NIELSEN B, 1991, PHYS REV B, V44, P1812 SCHULTZ PJ, 1988, PHYS REV LETT, V61, P187 SCHULTZ PJ, 1988, REV MOD PHYS, V60, P701 SEIDEL TE, 1991, NUCL INSTRUM METH B, V55, P17 SIMPSON PJ, 1991, POSITRON BEAMS SOLID, P125 TAKAI M, 1989, NUCL INSTRUM METH B, V39, P352 TANDBERG E, 1989, CAN J PHYS, V67, P275 VANDERDRIFT A, 1967, PHILIPS RES REP, V22, P267; NR: 27; TC: 0; J9: APPL SURF SCI; PG: 6; GA: QD950Source type: Electronic(1
Kanter Revisited: Gender, Power and (In)visibility
Get PDFThis paper revisits Kanter's (1977) seminal work Men and Women of the Corporation, rereading her account of numerical advantage and disadvantage through a poststructuralist lens which exposes hidden dimensions of gendered power. This lens is captured in the ‘(In)visibility Vortex’ (Lewis and Simpson, 2010) which highlights struggles and tensions around the norm through processes of preservation and concealment within the norm as well as dynamics of revealing, exposure and disappearance as features of the margins. The study draws on developments in feminist theorizing, specially around visibility, invisibility and power, to facilitate this rereading. In so doing, the author demonstrate that while Kanter retreated from explanations based on the gendering of organizations or from recognition of gendered power, these dynamics can be identified in her text. The authors suggest that rereading classic texts can surface dimensions of organizations that have contemporary significance and can inform future research
The People v. Orenthal James Simpson: Race and Trial Advocacy
No full textThis chapter focuses on the trial story behind the high profile case of People v. Orenthal James Simpson. As the author points out, the Simpson case focused attention on some of the most important issues in the criminal justice system, including class and race disparities, DNA evidence, and police perjury. The author here focuses on the issue of race--its significance in the trial and how it affected the advocacy of the lawyers. She discusses the emotional conflicts over race within the defense and prosecution teams and compares and contrasts the approaches that each side ultimately decided to take. The author examines how race affected the choice of lawyers, venue and jury selection, the direct and cross-examination of the trials most controversial witness, and the closing arguments. She suggests that the strategic decisions about race made by both sides may have largely determined the outcome of the case.https://digitalcommons.wcl.american.edu/facsch_bk_contributions/1099/thumbnail.jp
Abstract A24: A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer
No full textAbstract
Cancer is characterized by deregulated cell growth and proliferation, both of which are associated with hyperactivation of ribosome biogenesis. Inhibition of ribosome biogenesis using CX-5461, a specific inhibitor of RNA polymerase I-dependent transcription, has shown therapeutic efficacy in a MYC driven B-cell lymphoma mouse model, which is enhanced when used in combination with the mTORC1 inhibitor Everolimus. However, the therapeutic potential of CX-5461 in solid cancers is yet to be determined.
Our preliminary data utilizing a panel of 36 ovarian cancer (OVCA) cell lines suggest that acute CX-5461 treatment results in cell cycle arrest and does not induce apoptosis. We hypothesize that the identification of genes that can be targeted to cooperate with CX-5461 will define novel drug combinations for the improved treatment of OVCA. Therefore, we performed a genome-wide RNAi screen to identify synthetic lethal genes with CX-5461 in the high-grade serous ovarian cancer (HGSOC) cell line OVCAR4. Pathway enrichment analysis of the candidate hits showed significant enrichment in the homologous recombination DNA repair (HR) pathway. Synergy with CX-5461 was validated in multiple HGSOC cell lines by both genetic and pharmacological inhibition of HR pathway components. We are currently investigating the mechanism of this synergy and will further assess efficacy in vivo.
As HR deficiency is observed in 20% of OVCA patients, we suggest that future application of our studies will lead to new therapeutic options to improve the survival of this cohort of patients.
Citation Format: Shunfei Yan, Keefe T. Chan, Kaylene J. Simpson, Elaine Sanij, Karen E. Sheppard, Katherine M. Hannan, Ross D. Hannan, Richard B. Pearson. A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer [abstract]. In: Proceedings of the AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; 2016 Nov 2-5; Montreal, QC, Canada. Philadelphia (PA): AACR; Mol Cancer Res 2017;15(4_Suppl):Abstract nr A24.</jats:p
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