1,721,882 research outputs found
Correction: Metagenomics in ophthalmology: Current findings and future prospectives (BMJ Open Ophthalmology (2019) 4 (e000248) DOI: 10.1136/bmjophth-2018-000248)
No full textThe license type for this paper has changed from CC BY-NC to CC BY
Standardizing the Descemet Membrane Endothelial Keratoplasty Graft Preparation Method in the Eye Bank-Experience of 527 Descemet Membrane Endothelial Keratoplasty Tissues: A Proposed Modification
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Corneal Indocyanine Green Angiography to Guide Medical and Surgical Management of Corneal Neovascularization
No full textPurpose: To illustrate the role of corneal angiography in the clinical assessment and surgical treatment of patients with complex corneal neovascularization (CoNV). Methods: A case series of 3 patients with CoNV is presented whose management was guided by indocyanine green (ICG) and fluorescein corneal angiography. In the first case, there was recurrent lipid exudation into an intrastromal cleft from CoNV; in the second, there was progressive exudation from CoNV at the graft-host interface; in the third, CoNV was associated with rejection after deep anterior lamellar keratoplasty. Results: In the first case, angiography helped to identify and treat the feeder vessels and stop further leakage. In the second case, it was possible using angiography to differentiate CoNV arising from iris and limbal vasculature enabling angiographic-guided fine-needle diathermy with cessation of exudation. In the third case, angiography revealed the location of CoNV in the host-graft interface after deep anterior lamellar keratoplasty, rather than within the corneal stroma. Conclusions: Corneal angiography is a useful diagnostic tool to guide medical and surgical management of CoNV by enabling the localization of vessel depth and topography
Spontaneous descemet membrane tear after uneventful big-bubble deep anterior lamellar keratoplasty
No full textPurpose: To report a case of delayed spontaneous Descemet membrane (DM) tear after big-bubble Deep Anterior Lamellar Keratoplasty (DALK). Methods: Uneventful big-bubble DALK was performed on a 29-year-old patient with advanced keratoconus. No injury to DM was noted intraoperatively and in the first postoperative week. On examination after 1 month, the patient presented with tear and partial detachment of Descemet membrane (DMD). Results: Circumscribed eccentric stromal edema, but not DMD, partially resolved after a 3-month observational period. Conclusions: A tear to DM and consecutive DMD may occur spontaneously after big-bubble DALK. Sutural traction and regressing corneal stromal edema may be etiologic factors
Angiographic Evaluation of Inflammation in Atopic Keratoconjunctivitis
No full textPurpose: Grading of disease activity in patients with atopic keratoconjunctivitis (AKC) is limited by intra- and inter-observer variability. The aim of this study was to identify angiographic parameters to help evaluate inflammation and disease activity. Methods: In 12 patients (4 with active, 2 with inactive AKC, and 6 controls), disease activity were assessed using a validated biomicroscopic grading scale. Imaging of upper tarsal conjunctiva was undertaken using color photography, fluorescein (FA) and indocyanine green angiography (ICGA). Results: Extravascular ICG leakage only occurred in patients with active disease (mean 84.6 ± 28.8 s) except in one patient with inactive disease but only after 6 min. Transepithelial leakage of fluorescein occurred in all patients with active AKC (mean 63.5 ± 17.8 s) but not in patients with inactive disease or controls. Conclusions: Conjunctival transepithelial leakage of fluorescein and extravascular interstitial accumulation of ICG may be useful markers of disease activity patients in AKC
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