42 research outputs found
Development and the G20
No full textThis publication examines what role the G20 can play in international development.
Key findings:
Development is a key component of the G20, but there are concerns over the effectiveness of the current development agenda.
The criticism includes that the development agenda is too diffuse and mostly distant to the G20’s main activities.
But the G20 development agenda has made progress in some important areas, including increasing the resources of the international financial institutions, infrastructure, food security, financial inclusion and reducing the cost of remittances.
However development and global economic issues cannot be treated in isolation; development must be ‘mainstreamed’ and clearly seen as part of the G20’s core agenda.
To the extent that Australia can help strengthen the G20 when it assumes the chair in 2014, and make tangible progress in such areas as - economic growth, financial regulation, trade, financial inclusion, infrastructure and climate change financing – it can make a significant contribution to promoting development and reducing poverty.
Authored by Mike Callaghan AM, Annmaree O’Keeffe AM, Robin Davies, Susan Harris Rimmer , Steve Price-Thomas, Sabina Curatolo, Julia Newton-Howes and Michelle Lettie
Synergistic Effects of Extra X Chromosome on Development of Systemic Lupus Erythematosus and Sjögren Disease in Klinefelter and Triple X Syndrome: A Retrospective Cohort Study
No full textOBJECTIVE: Systemic lupus erythematosus (SLE) and Sjögren disease (SjD) are autoimmune diseases with significant female predominance. The prevalence of SLE is increased in Klinefelter syndrome (KS) compared with the general male population. Our study investigates the dose effects of extra X chromosomes on the development of SLE and SjD in KS and triple X syndrome compared with the general population.
METHODS: This multicenter, retrospective cohort study used TriNetX, a global federated research database. Using International Statistical Classification of Diseases, Tenth Revision, Clinical Modification codes, patients with a diagnosis of SLE or SjD in the general population, as well as those with SLE and SjD in KS (karyotype 47,XXY) and triple X syndrome (karyotype 47,XXX) from January 1, 2010, to January 1, 2024, were identified. Fisher\u27s exact test was used to calculate the relative risk of SLE and SjD in males with KS and females with triple X syndrome compared with the general population. The 95% confidence intervals (95% CI) were obtained with STATA statistical software.
RESULTS: A total of 113,748,373 patients were identified. The prevalence of SLE and SjD was 0.59% and 0.077%, respectively, in men, and 0.381% and 0.388% for SLE and SjD, respectively, in women. The male-to-female ratios for all ages were 1:6.4 for SLE and 1:5 for SjD. The prevalence of KS and triple X syndrome in the general population was 0.0017% and 0.0010%, respectively. Among patients with KS, the prevalence of SLE and SjD was both 0.5%. Among patients with triple X syndrome, the prevalence of SLE and SjD was 1.3% and 0.8%, respectively. SLE was 8.5-fold (95% CI 4.6-15.8) and SjD was 6.6-fold (95% CI 3.56-12.26) more common in KS compared with the general male population (P \u3c 0.001 by Fisher\u27s exact test). SLE was 3.5-fold (95% CI 2.09-5.72) and SjD was 2.3-fold (95% CI 1.22-4.20) more common in triple X syndrome compared with the general female population (P \u3c 0.001 and P \u3c 0.05, respectively).
CONCLUSION: The extra X chromosome in KS and triple X syndrome appears to confer a nonproportional, synergistic dose effect on the development of SLE and SjD when compared with the general population
CD40 ligand antagonist dazodalibep in Sj\uf6gren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial
No full text\ua9 The Author(s) 2024. Sj\uf6gren’s disease (SjD) is a chronic, systemic autoimmune disease with no approved disease-modifying therapies. Dazodalibep (DAZ), a novel nonantibody fusion protein, is a CD40 ligand antagonist that blocks costimulatory signals between T and B cells and antigen-presenting cells, and therefore may suppress the wide spectrum of cellular and humoral responses that drive autoimmunity in SjD. This study was a phase 2, randomized, double-blinded, placebo (PBO)-controlled trial of DAZ with a crossover stage in two distinct populations of participants with SjD. Population 1 had moderate-to-severe systemic disease activity and population 2 had an unacceptable symptom burden and limited systemic organ involvement. All participants had a diagnosis of SjD, with 21.6% and 10.1% having an associated connective tissue disease (rheumatoid arthritis or systemic lupus erythematosus) in populations 1 and 2, respectively. The remaining participants would be considered as having primary Sj\uf6gren’s syndrome. The primary endpoint for population 1 (n = 74) was the change from baseline in the European League Against Rheumatism Sj\uf6gren’s Syndrome Disease Activity Index at day 169. The primary endpoint for population 2 (n = 109) was the change from baseline in the European League Against Rheumatism Sj\uf6gren’s Syndrome Patient Reported Index at day 169. The primary endpoints (least squares mean \ub1 standard error) were achieved with statistical significance for both population 1 (DAZ, −6.3 \ub1 0.6; PBO, −4.1 \ub1 0.6; P = 0.0167) and population 2 (DAZ, −1.8 \ub1 0.2; PBO, −0.5 \ub1 0.2; P = 0.0002). DAZ was generally safe and well tolerated. Among the most frequently reported adverse events were COVID-19, diarrhea, headache, nasopharyngitis, upper respiratory tract infection, arthralgia, constipation and urinary tract infection. In summary, DAZ appears to be a potential new therapy for SjD and its efficacy implies an important role for the CD40/CD40 ligand pathway in its pathogenesis. ClinicalTrials.gov identifier: NCT04129164
Research Regarding the Interaction Genotype x Technological Factors in Morphological Features of Chilli Pepper Cultivated in Solaria at the Experimental Station of Timisoara, Romania
No full textAbstractThe history of bell pepper started 3,000-4,000 years ago, in Peru, in the old Inca Empire, whose civilisation used to practice a flowering agriculture. In a museum of Lima, Peru, they exhibited bell pepper fruits old a few thousand years and vases representing plants and bell peppers found during archaeological findings in Inca tombs. Experiments carried out during 2014-2015 had a polyfactorial character; variants were set after the randomised block method with three replicates specific to experiments in forced protected areas of vegetable culture. Factor A (cultivar) with 5 graduations: a1 – Délibáb F1; a2 – Sláger F1; a3 – Bolero F1; a4 – SJD 5; a5 – SJN 5. Factor B (planting scheme) with 4 graduations: b1 – 40+80x20cm → 8,3 plants/m2; b2 – 40+80x30cm → 5,5 plants/m2; b3 – 40+80x40cm → 4,2 plants/m2; b4 – 40+80x50cm → 3,3 plants/m2. Unilateral statistic evaluation of the influence of genotype and of plant density on fruit length is distinctly significant on the background of significant influence of environmental conditions during the experimental years. Changing the planting distance per row from 20 to 30 and to 50cm resulted in significant increase of fruit length of 8-18%. The combined effect of genotype and plant density had considerable influences (18.81%) on fruit diameter, a value that is distinctly significant. The bell pepper hybrid Bolero and the bell pepper line SJD 5 cultivated at a plant density of 8.3 plants/m2 (80/40x20cm) produce pulp thickness superior to that of the experimental mean
Variants in the <em>DDX6-CXCR5</em> autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland
No full text\ua9 2025 The Author(s). Objectives: Sj\uf6gren\u27s disease (SjD) and systemic lupus erythematosus (SLE) share genetic risk at the DDX6-CXCR5 locus (11q23.3). Identifying and functionally characterising shared SNPs spanning this locus can provide new insights into common genetic mechanisms of autoimmunity. Methods: Transdisease meta-analyses, fine-mapping, and bioinformatic analyses prioritised shared likely functional single nucleotide polymorphisms (SNPs) for allele-specific and cell type–specific functional interrogation using electromobility shift, luciferase reporter, and quantitative chromatin conformation capture assays and clustered regularly interspaced short palindromic repeat (CRISPR) gene regulation. Results: Five shared SNPs were identified as likely functional in primary human immune cells, salivary gland and kidney tissues: rs57494551, rs4936443, rs4938572, rs7117261, and rs4938573. All 5 SNPs exhibited cell type-specific and allele-specific effects on nuclear protein binding affinity and enhancer/promoter regulatory activity in immune, salivary gland epithelial, and kidney epithelial cell models. Mapping of chromatin–chromatin interactions revealed a chromatin regulatory network that expanded beyond DDX6 and CXCR5 to include PHLDB1, lnc-PHLDB1-1, BCL9L, TRAPPC4, among others. Coalescence of functional assays and multiomic data analyses indicated that these SNPs likely modulate the activity of 3 regulatory regions: intronic rs57494551 regulatory region, intergenic SNP haplotype (rs4938572, rs4936443, and rs7117261) regulatory region, and rs4938573 regulatory region upstream of the CXCR5 promoter. Conclusions: Shared genetic susceptibly at the DDX6-CXCR5 locus in SjD and SLE likely alters common mechanisms of autoimmunity, including interferon signalling (DDX6), autophagy (TRAPPC4), and lymphocytic infiltration of disease-target tissues (CXCR5). Further, using multiomic data from patients with SjD, combined with bioinformatic and in vitro functional studies, can provide mechanistic insights into how genetic risk influences the biological pathways that drive complex autoimmunity
»Ein Gespenst geht um in der BRD – das Gespenst der Jugendzentrumsbewegung!«. Die SJD – Die Falken und die unabhängige Jugendzentrumsbewegung in den 1970er Jahren
No full textProfessor Mary Condon to serve as Dean (Interim) of Osgoode from May 1, 2018 to June 30, 2019 while search is underway for Dean
No full textProfessor Mary Condon’s appointment as Dean (Interim) follows on the heels of the completion on April 30, 2018 of Lorne Sossin’s eight-year term as Dean.
Condon, who has been an Osgoode faculty member for 25 years, has served as the Law School’s Associate Dean (Academic) since 2016. In this capacity she has been responsible for curriculum planning and chairs the School’s Tenure and Promotions, Grades Review, and Faculty Appointments Committees. Professor Trevor Farrow, who has previously served as Associate Dean (Academic), will return to the role.
Condon holds a law degree from Trinity College, Dublin, and MA, LLM and SJD degrees from the University of Toronto, and is a member of the Bar of Ontario. The author of numerous publications, her research and teaching interests are in the securities law area.
From 2005 to 2014, she was a member of the Board of Trustees of the York University Pension Fund. Beyond York, she was appointed by the Ontario government as a Commissioner and Board Member of the Ontario Securities Commission (2008-2016), serving as a full-time Vice-Chair from 2011 to 2014. In February 2018, she was appointed to the Board of Directors of the Capital Markets Authority Implementation Organization
A search for non-thermal radio emission from jets of massive young stellar objects
No full textMassive young stellar objects (MYSOs) have recently been shown to drive jets whose particles can interact with either the magnetic fields of the jet or ambient medium to emit non-thermal radiation. We report a search for non-thermal radio emission from a sample of 15 MYSOs to establish the prevalence of the emission in the objects. We used their spectra across the L, C, and Q bands along with spectral index maps to characterize their emission. We find that about 50 per cent of the sources show evidence for non-thermal emission with 40 per cent showing clear non-thermal lobes, especially sources of higher bolometric luminosity. The common or IRAS names of the sources that manifest non-thermal lobes are V645Cyg, IRAS 22134+5834, NGC 7538 IRS 9, IRAS 23262 + 640, AFGL 402d, and AFGL 490. All the central cores of the sources are thermal with corresponding mass-loss rates that lie in the range of ∼3 × 10-7 to 7 ×10-6, M⊙, yr-1. Given the presence of non-thermal lobes in some of the sources and the evidence of non-thermal emission from some spectral index maps, it seems that magnetic fields play a significant role in the jets of massive protostars. Also noted is that some of the sources show evidence of binarity and variability. © 2019 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society.</p
Measured proton electromagnetic structure deviates from theoretical predictions
No full textThe visible world is founded on the proton, the only composite building block of matter that is stable in nature. Consequently, understanding the formation of matter relies on explaining the dynamics and the properties of the proton's bound state. A fundamental property of the proton involves the response of the system to an external electromagnetic field. It is characterized by the electromagnetic polarizabilities(1) that describe how easily the charge and magnetization distributions inside the system are distorted by the electromagnetic field. Moreover, the generalized polarizabilities(2) map out the resulting deformation of the densities in a proton subject to an electromagnetic field. They disclose essential information about the underlying system dynamics and provide a key for decoding the proton structure in terms of the theory of the strong interaction that binds its elementary quark and gluon constituents. Of particular interest is a puzzle in the electric generalized polarizability of the proton that remains unresolved for two decades(2). Here we report measurements of the proton's electromagnetic generalized polarizabilities at low four-momentum transfer squared. We show evidence of an anomaly to the behaviour of the proton's electric generalized polarizability that contradicts the predictions of nuclear theory and derive its signature in the spatial distribution of the induced polarization in the proton. The reported measurements suggest the presence of a new, not-yet-understood dynamical mechanism in the proton and present notable challenges to the nuclear theory
Announcement Of Appointment Of Interim Dean of Osgoode Hall Law School
No full textYork President and Vice-Chancellor Rhonda L. Lenton and Interim Vice-President Academic and Provost Lisa Philipps issue the following announcement to the University community:
We are pleased to inform the York community that Professor Mary Condon has agreed to take on the role of Interim Dean of Osgoode Hall Law School, following the departure of Dean Lorne Sossin next April. The Board of Governors has now approved the recommendation of this appointment. Professor Condon’s appointment will be from May 1, 2018 – June 30, 2019. We will be following up at the next Osgoode Faculty Council meeting for a discussion about the interim plan, next steps and initiating a search for the next Dean of Osgoode Hall Law School.
Professor Condon will be well known to members of the York community. She joined the Osgoode faculty in 1992, and has served as the School’s Associate Dean (Academic) since 2016. In this capacity she chairs the School’s Tenure and Promotions, Grades Review, and Faculty Appointments Committees. In the past, she has chaired the Faculty Recruitment Committee, and she previously served as Director of Osgoode’s Graduate Program.
Professor Condon holds a law degree from Trinity College, Dublin, and MA, LLM and SJD degrees from the University of Toronto. She is a member of the Bar of Ontario. Her research interests include the regulation of securities markets, investment funds, online investing, and pensions. She is the author of a number of books, articles and policy papers in these areas, and has given lectures in Canada and internationally. She teaches courses in securities regulation and advanced securities in the JD program, as well as directing and teaching in the Professional LLM in Securities Law program. From 2005-2014, she was a member of the Board of Trustees of the York University Pension Fund.
Beyond York, she was appointed by the Ontario government as a Commissioner and Board Member of the Ontario Securities Commission (2008-2016), serving as a Vice-Chair from 2011-2014, in which role she sponsored a number of important policy initiatives and issued adjudicative decisions. From 2014-2016 she was a member of the National Steering Committee on Financial Literacy. In 2009, she held the Walter S. Owen Chair in Business Law in the Faculty of Law at the University of British Columbia, where she was also the codirector of the National Centre for Business Law.
We very much appreciate Professor Condon’s willingness to undertake this important role. She will provide outstanding leadership as Interim Dean, and we look forward to working with her and colleagues in Osgoode to continue the advancement of the school’s vision and reputation
