111 research outputs found
Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors
No full textAbstract Correction to Erik Serrao, Srinivas Odde, Kavya Ramkumar and Nouri Neamati: Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors. Retrovirology 2009, 6:25. Since the recent publication of our article (Neamati, Retrovirology 2009, 6:25), we have noticed an error which we would like to correct and we would like to apologise to the readers for this mistake.</p
Experimental evaluation of long term evolution-based NC OFDM secondary-to-secondary interference
No full textScarcity of spectrum resources, inefficient spectrum usage and the inflexibility of the current spectrum assignment are few of the major roadblocks in the development of new wireless communication standards. Secondary spectrum sharing has become a viable solution to alleviate this problem. Secondary users are unlicensed devices that use opportunistic spectrum access to identify vacant frequency bins and thereby utilize the spectrum. For advanced wireless communication standards like the Long Term Evolution (LTE) which primarily calls for higher data rates, evaluation of design parameters for ensuring efficient coexistence of heterogeneous secondary users and guaranteeing acceptable minimum level of performance becomes essential. Additionally, the understanding of the interference between secondary users occupying adjacent frequency bands for their transmission is imperative. This thesis focuses on the coexistence of secondary users in the same band assuming that the primary spectrum is found available. By Implementing two Non Contiguous Orthogonal Frequency Division Multiplexing ( NC-OFDM) based secondary transmitters on a real time platform, the design parameters that need to be considered to ensure efficient coexistence have been identified and investigated. The performance degradations observed at a particular secondary link due to presence of another interfering secondary link occupying adjacent frequency bands for its transmission have also been studied. This thesis also focuses on implementation of algorithms to modify the existing NC-OFDM transmission at the secondary transmitter end to reduce its Interference effects on the other secondary links operating within the same band. The focus is on an LTE-based Secondary Non Contiguous Orthogonal Frequency Division Multiplexing Transceiver on a Real Time Platform developed by National Instruments. The various blocks needed to design a real time LTE based communications links are discussed. An experimental LTE-to-LTE interference analysis based on the Real Time Platform and the designed system is presented.M.S.Includes bibliographical referencesby Ajay Ramkumar Iye
Effect of intravenous dexmedetomidine administered as bolus or as bolus-plus-infusion on subarachnoid anesthesia with hyperbaric bupivacaine
No full textBackground: Subarachnoid anesthesia is a widely practiced regional anesthetic for infraumbilical surgeries. Intravenous dexmedetomidine is known to prolong both sensory and motor blockade when administered along with subarachnoid anesthesia.
Material and Methods: Seventy-five patients scheduled to undergo elective infraumbilical surgeries under subarachnoid anesthesia were randomly allocated to one of the three groups. Group B received intravenous saline over 10 min followed by 12.5 mg intrathecal bupivacaine and then intravenous saline over 60 min. Group bupivacaine + dexmedetomidine bolus (BDexB) received intravenous dexmedetomidine (1 μg/kg) over 10 min followed by 12.5 mg intrathecal bupivacaine and then intravenous saline over 60 min. Group bupivacaine + dexmedetomidine bolus-plus-infusion (BDexBI) received intravenous dexmedetomidine (0.5 μg/kg) over 10 min followed by 12.5 mg intrathecal bupivacaine and then intravenous dexmedetomidine (0.5 μg/kg) over 60 min. Onset of analgesia (at T10), complete motor block (Bromage score 3), and highest level of analgesia were noted. Sensory and motor levels were checked periodically till sensory recovery (at S2–S4) and complete motor recovery (Bromage score 0). Ramsay sedation score and incidence of bradycardia/hypotension were noted.
Results: Sensory recovery was significantly longer in Group BDexB (303 min) and Group BdexBI (288 min) as compared to Group B (219.6 min). Motor recovery was also significantly prolonged in Group BDexB (321.6 min) and Group BDexBI (302.4 min) as compared to Group B (233.4 min). Patients receiving dexmedetomidine were sedated but were easily arousable.
Conclusion: Intravenous dexmedetomidine given as bolus or bolus-plus-infusion with intrathecal hyperbaric bupivacaine prolongs both sensory and motor blockade
Regulation of senescence in cancer and aging
No full textCo-author Charusheila Ramkumar is a student in the Cell Biology program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by contributing to aging. The emergence of senescence as an effective tumor suppression mechanism is highlighted by recent demonstration that senescence prevents proliferation of cells at risk of neoplastic transformation. Consequently, induction of senescence is recognized as a potential treatment of cancer. Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be discussed
RAMKUMAR MUKHAPADHYAYER ‘DHANAPATIR SINHALYATRA’ : NABARUPE CHANDIMANGAL/ রামকুমার মুখোপাধ্যায়ের ‘ধনপতির সিংহলযাত্রা’ : নবরূপে চন্ডীমঙ্গল
No full textoai:ojs2.tirj.org.in:article/2Ramkumar Mukherjee\u27s novel \u27Dhanpati\u27s Sinhala Yatra\u27 is also medieval in terms of language. The novel has been reimagined by Chandimangal. Ramkumar Mukherjee has adopted the first part of the narrative of the merchant section in his novel. From Dhanpati\u27s Sinhala Yatra to captivity. Here, the novelist has looked back at medieval Bengal and Bengalis from a distance of several centuries, keeping Mukund\u27s poetry in front of him. He has made no attempt to drag the past into the present. Nor has he taken the present into the past and placed it there. In this book, the past cannot be seen in the present and the present in the past. A pure historical setting has been created where there is no shadow of the twenty-first century. Chapters such as the lifting of the Saptadinga, Dhanpati\u27s journey to the Dingaghata, Ajay Yatra, Muktabeni, and the journey of rivers and streams describe extinct rivers, towns, etc. The novel contains themes such as mythological consciousness, religious ideals, and a reevaluation of divine consciousness. Dhanpati traveled to the southern country in the hope of prosperity. However, his fate and destiny were determined by the hideous plots and cruelty of two goddesses. Ignoring many ominous signs and the desperate pleas of Khulna, Dhanpati has to travel helplessly towards the inevitable end. This is his destiny. Ramkumar Mukherjee has presented the novel \u27Dhanpati\u27s Singhal Yatra\u27 in a magical bond of intense fascination with the tradition of Bengali cultural heritage. The novel has a unique and modern reconstruction of the well-known Afghan poem of the medieval \u27Chandimangal\u27. The novelist has kept the basic structure of the story intact here, but has analyzed the psychological depth of the characters and the socio-economic context of the time from a modern perspective. As a result, it emerges as a picture of the conflict between man and time instead of the story of the greatness of the Goddess. In the novel, Dhanpati is a prosperous merchant of Ujjainnagar, but he has endless questions and doubts about the social system of the time. He wants to magnify the efforts and logic of man instead of the miracles of the conventional gods and goddesses. This rational mind has taken him against the conventional beliefs and conventional customs. And later it has become the main reason for the conflict in his life. On the king\u27s orders, Dhanpati has to undertake a journey to Sinhala despite his reluctance. Before the journey, the wish of his husband for his well-being did not open, so when the puja of Goddess Chandi was organized, the rational, confident, and realistic leader trampled the auspicious place of the Goddess with contempt. To him, the greatness of the Goddess is irrational and miraculous. However, the author portrays this insult not only as an insult, but as a clash between traditional beliefs and modern logic. The novel is not just a religious story, but also a story of human survival in the face of adversity. Overall, the novel has become a reinterpretation of the medieval \u27Chandimangal\u27 poem
HCI in interactive segmentation: Human-computer interaction in interactive segmentation of CT images for radiotherapy
No full textMechatronic Desig
Ekaler konthe, sekaler kothon : ramkumar mukhopadhyayer ‘Dhonopotir singhol jatra’/ একালের কণ্ঠে, সেকালের কথন : রামকুমার মুখোপাধ্যায়ের ধনপতির সিংহল যাত্রা
No full textThe trend of reconstruction or renewal in literature and art is something new. No It is possible to break the boundaries of any subject through innovation. This is a natural tendency of any culture. This trend has started in Bengali literature long ago. An attempt has been made to break the conventional meditation concept and tradition of \u27Charyagiti\u27 or \u27Mangalkabhya\u27 and show it in a new light. Which has been reflected in various branches of literature. For example, drama, poetry, novels, short stories. The style or form of literature has been written in new ways. In keeping with the times, people have tried to grasp tradition in the light of thought and consciousness. The trend of innovation is flowing in Bengali literature from natural interest, desire and the need for pleasure. After the 19th century, the 20th century and even after the 21st century, that trend has not stopped. Keeping the literary elements of ancient and medieval times in front, he analyzed and explored the individual\u27s own thoughts. One such novelist in 21st century Bengali literature is \u27Ramkumar Mukhopadhyay\u27.
He has made the elements of past history special by breaking them up with his artistic vision. He has written novels like \u27Dhanpati\u27s Singhal Yatra\u27 and \u27Har-Parvati Katha\u27, focusing on the medieval theme, \u27Mangalkavya\u27, which is ingrained in the Bengali consciousness and mind two. We will shed light on these characteristics of the author\u27s innovation and modern thinking in the article \u27In the Voice of a Time, When in Ramkumar Mukherjee\u27s Novels of a Time Selected\u27. 
Nitric oxide synthase regulation and diversity: implications in Parkinson's disease
No full textNitric oxide (NO) is a janus faced chemical messenger, which, in the recent years, has been the focus of neurobiologists for its involvement in neurodegenerative disorders in particular, Parkinson's disease (PD). Nitric oxide synthase, the key enzyme involved in NO production exists in three known isoforms. The neuronal and inducible isoforms have been implicated in the pathogenesis of PD. These enzymes are subject to complex expressional and functional regulation involving mRNA diversity, phosphorylation and protein interaction. In the recent years, mRNA diversity and polymorphisms have been identified in the NOS isoforms. Some of these genetic variations have been associated with PD, indicating an etiological role for the NOS genes. This review mainly focuses on the NOS genes-their differential regulation and genetic heterogeneity, highlighting their significance in the pathobiology of PD
Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1
No full textFirst author Charusheila Ramkumar is a student in the Cell Biology program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.About half of patients with diffuse large B-cell lymphoma (DLBCL) do not respond to or relapse soon after the standard chemotherapy, indicating a critical need to better understand the specific pathways perturbed in DLBCL for developing effective therapeutic approaches. Mice deficient in the E3 ubiquitin ligase Smurf2 spontaneously develop B-cell lymphomas that resemble human DLBCL with molecular features of germinal centre or post-germinal centre B cells. Here we show that Smurf2 mediates ubiquitination and degradation of YY1, a key germinal centre transcription factor. Smurf2 deficiency enhances YY1-mediated transactivation of c-Myc and B-cell proliferation. Furthermore, Smurf2 expression is significantly decreased in primary human DLBCL samples, and low levels of Smurf2 expression correlate with inferior survival in DLBCL patients. The Smurf2-YY1-c-Myc regulatory axis represents a novel pathway perturbed in DLBCL that suppresses B-cell proliferation and lymphomagenesis, suggesting pharmaceutical targeting of Smurf2 as a new therapeutic paradigm for DLBCL
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