15 research outputs found
Efficacy and safety of once daily triamcinolone acetonide aqueous nasal spray in adults with non-allergic and allergic rhinitis
No full textBackground: The efficacy of corticosteroid has not been thoroughly studied in the treatment of non-allergic rhinitis. This study was designed to compare the efficacy of nasal corticosteroid in patients with allergic rhinitis (AR), and non-allergic rhinitis (NAR). Methods: The efficacy of triamcinolone acetonide nasal spray (TANS) on total nasal symptom scores (TNSS), and nasal peak inspiratory flow rate (nPIFR) was studied in a six-week parallel-group trial of NAR (n: 25), and AR (n: 16) patients. Health-related quality of life (HRQoL) and Epworth Sleepiness Scale (ESS) were also analysed. Results: The TNSSs, and symptom scores of conjunctivitis, snoring, and postnasal drainage were significantly improved in both groups, after two and six weeks of treatment. In contrast to AR, patients with NAR had statistically significant improvement in nasal obstruction, and postnasal drainage beginning from two weeks of the treatment. nPIFR slightly increased in both groups. Scores of generic (SF-36), rhinitis specific (MiniRQLQ) and ESS questionnaires generally improved better in AR than MAR. TANS was well-tolerated in AR and NAR groups with minor adverse events including headache, nasal burning, and bitter mouth taste. Conclusions: Our study disproved the idea of ineffectiveness of corticosteroid treatment in NAR, and showed that triamcinolone acetate may be an alternative drug in the treatment of NAR. (C) 2012 SEICAP Published by Elsevier Espana, S.L. All rights reserved.Kirikkale University Projects of Scientific ResearchesKirikkale University [2007/4]This work was supported by a grant from Kirikkale University Projects of Scientific Researches (grant no: 2007/4) which was received by Baccioglu Kavut, and Kalpaklioglu
Association Between Tuberculosis and Atopy: Role of the CD14-159C/T Polymorphism
No full textBackground: The development of allergic hypersensitivity depends on both genetic and environmental factors. Different amounts of microbial products could affect patients with atopy and different genotypes. Objective: We aimed to evaluate the role of varying degrees of exposure to infection by Mycobacterium tuberculosis (tuberculosis) in atopic patients and analyze the association with genetic factors. Methods: We performed CD14-159C/T genotyping in atopic patients (n=118) and healthy individuals (n=62) and recorded the following variables: rural lifestyle, exposure to persons with tuberculosis, bacille Calmette-Guerin (BCG) vaccination, tuberculin skin test (TST), skin prick test, and phenotypes of atopy. Blood samples were analyzed for soluble-CD14 (sCD14), interferon (IFN) gamma, total immunoglobulin (Ig) E, and eosinophil levels. A score was used to identify the likelihood of exposure to tuberculosis. Results: Almost all the study participants had had a BCG vaccination, and half had a positive TST result. No differences were observed between atopic patients with high/low tuberculosis scores and CD14 genotypes in terms of atopic phenotypes, allergen sensitization, and levels of total IgE, sCD14, and IFN-gamma. However, the frequency of asthma was higher in atopic patients with a high tuberculosis score and was not associated with CD14 genotypes. Eosinophil counts in blood were higher in atopic patients with a high tuberculosis score and CC+CT genotypes. Conclusions: These results suggest that the C allele of the CD14-159C/T polymorphism has a marked effect on eosinophil levels in atopic patients with increased exposure to tuberculosis. In addition, the degree of exposure to tuberculosis in atopic patients may modify the development of asthma.Kirikkale UniversityKirikkale University [2008/5]This work was supported by a grant from Kirikkale University Projects of Scientific Research (Grant No. 2008/5) awarded to Drs Baccioglu Kavut, Kalpaklioglu, and Ayaslioglu. None of the authors have any other financial disclosures to make
Contribution of Neurogenic and Allergic Ways to the Pathophysiology of Nonallergic Rhinitis
No full textBackground: A neuroallergic interaction was reported in the pathogenesis of allergic rhinitis (AR), but the pathophysiology of nonallergic rhinitis (NAR) is poorly understood. We aimed to explore the contribution of neuroallergic mechanisms to the pathogenesis of NAR. Methods: Subjects were divided into three groups - NAR patients (n = 25), AR patients (n = 16) and the control group (n = 10) - and were assessed using the nasal provocation test (NPT) with house dust mite. Total symptom scores, nasal inspiratory peak flow and nasal lavage were performed before and after NPT. Nasal brushing and scraping was done after NPT. Results: NPT was positive in NAR (52%) and AR (100%) patients and negative in all controls. After NPT, total symptom scores increased in both rhinitis groups. Post-NPT values of nasal inspiratory peak flow decreased only in AR patients. NAR patients showed a similar inflammatory cell profile in the nasal smears to AR patients which was different in controls. There were more tryptase- and immunoglobulin E (IgE)-positive cells in the nasal mucosa of AR patients, and more substance-p-positive cells were observed in NAR patients compared with controls. However, IgE- and tryptase-positive cells in NAR patients and substance-p-positive cells in AR patients were detectable in nasal mucosa, but rarely in the controls. Comparing the values before and after NPT, tryptase significantly increased in the nasal lavages of AR and NAR patients, while house dust mite-specific IgE did not change. Conclusions: We showed the existence of a common pathophysiological mechanism with different contributions in AR and NAR. We conclude that the difference in dominance of neuroallergic ways may determine the major phenotype of rhinitis. Copyright (C) 2012 S. Karger AG, BaselKirikkale University Projects of Scientific ResearchesKirikkale University [2007/4]This work was supported by a grant from Kirikkale University Projects of Scientific Researches (grant No. 2007/4) which was received by Baccioglu Kavut and Fusun Kalpaklioglu
Intranasal Corticosteroid Theraphy in Idiopathic Rhinitis: a Comparative Study with Allergic Rhinitis
No full textIntranasal Corticosteroid Theraphy in Idiopathic Rhinitis: a Comparative Study with Allergic Rhinitis
No full textAmerican-Academy-of-Allergy-Asthma-and-Immunology Annual Meeting -- MAR 18-22, 2011 -- San Francisco, CA…Amer Acad Allergy Asthma & Immuno
Diagnostic tools for allergic rhinitis and asthma
No full textThe diagnosis of allergic airway diseases is based on symptoms, and the laboratory tests help us to classify the types. A correct diagnose is important, since the treatment will change in different types of diseases. For example, untreated rhinitis may result in other diseases like asthma, and deteriorate the quality of life. Therefore, early diagnosis of allergic airway diseases is important before the disease progresses. This review summarizes the currently known diagnostic tools which can be useful in daily practical life and researches, including assessment of symptoms, physical examination, allergy skin tests, total and specific IgE, nasal provocation test and assessment parameters (symptoms, nasal flow and secretions), nasal mucosal sampling, and pulmonary function test
Characteristics of nonallergic rhinitis
No full textNonallergic rhinitis (NAR) is a type of rhinitis with perennial symptoms, unknown aetiology, and no clear treatment suggestions. Even though NAR has similarities with allergic rhinitis with regards to its prevalence, symptoms and impairment on quality of life, its importance is underestimated in clinical practice. There is no single valid test for the diagnosis of NAR as typical rhinitis symptoms, negativity in allergy skin tests and/or specific IgE, and exclusion of nonallergic rhinitis types with known aetiology are required. Pathophysiology of NAR is poorly understood, but a key component involves activation of neurogenic or allergic pathways. The aim of this review was to describe the characteristics, diagnostic methods, prevalence, pathophysiology, and treatment of NAR in the light of recent publications
Comparison of nasal nitric oxide in allergic versus nonallergic rhinitis
No full textWorld Allergy and Asthma Congress of the European-Academy-of-Allergy-and-Clinical-Immunology and World-Allergy-Organization -- JUN 22-26, 2013 -- Milan, ITALY…European Acad Allergy & Clin Immunol, World Allergy Or
Allergic Rhinitis: Can We Identify Nonadherence to Therapy and Its Predictors Easily in Daily Practice?
No full textBackground: Allergic rhinitis (AR) is a common chronic condition with significant consequences if left untreated (eg, poor health outcomes, disease progression, and increased health care costs). However, about half of all patients do not fill their prescription. The factors associated with adherence are complex, and many remain poorly defined and understood. Objectives: This pilot study had 2 objectives. First, to determine whether the medication adherence report scale (MARS) can be applied to identify adherence/nonadherence in patients with AR using patients with chronic obstructive pulmonary disease (COPD) as controls. Second, to identify AR profiles that indicate a particularly high risk of nonadherence. Methods: AR patients completed the Eysenck Personality Questionnaire-Revised Abbreviated-Form (EPQR-A), the Short Form 36 Health Survey (SF-36), the Mini Rhinitis Quality of Life Questionnaire (Mini-RQLQ), and the MARS. Symptom severity was assessed before and after treatment. Results: The study population comprised 85 AR patients and 50 COPD patients. Females had worse adherence (significant only in total and unintentional scores) and higher extraversion scores. None of the personality traits predicted adherence. Neuroticism was negatively correlated with the SF-36 score (P<.001). A low to moderate correlation was observed between posttreatment improvement in specific/generic health-related quality of life and MARS scores in AR patients (P=.002, r=0.332; and P=.022, r=-0.251; respectively). Higher educational level was found to significantly increase adherence (P=.01, r=0.223). Conclusions: Our study did not reveal a personality effect. However, it did suggest that use of a brief, self-completed medication adherence questionnaire in daily practice can enable health professionals to identify suboptimal adherence in patients who would benefit from close follow-up
Predicting the outcome of a non-steroidal anti-inflammatory drug provocation test-do we really need it?
No full text30th Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) -- JUN 11-15, 2011 -- Istanbul, TURKEYKalpaklioglu, A. Fusun/0000-0002-6548-6932…European Acad Allergy & Clin Immunol (EAACI
