1,721,073 research outputs found
Update on immediate implant placement and immediate restoration after extraction
No full textPatientenkomfort und -zufriedenheit haben in allen Bereichen der Medizin an Bedeutung gewonnen. In der zahnärztlichen Implantologie wurden, diesem Trend folgend, innovative Behandlungskonzepte vorgestellt. Insbesondere die Sofortimplantation und -versorgung nach Extraktion eines nichterhaltungswürdigen Zahnes bietet im Vergleich zu den konventionellen Verfahren die größte Zeitersparnis und Kostenreduktion für den Patienten. Eine strenge Indikationsstellung ist maßgeblich für den Erfolg dieses Therapiekonzepts. Unter Berücksichtigung der Indikation, biologischer und anatomischer Faktoren sowie des prothetischen Versorgungs- und Belastungskonzepts bietet die Sofortimplantation nach Extraktion hinsichtlich Implantatüberleben und -erfolg vergleichbare Ergebnisse wie konventionelle Konzepte. Der vorliegende Artikel zeigt die chirurgischen und prothetischen Möglichkeiten sowie Komplikationen und Risiken auf der Grundlage des aktuellen wissenschaftlichen Kenntnisstandes zu dieser Thematik auf
Update on immediate implant placement and immediate restoration after extraction
No full textPatientenkomfort und -zufriedenheit haben in allen Bereichen der Medizin an Bedeutung gewonnen. In der zahnärztlichen Implantologie wurden, diesem Trend folgend, innovative Behandlungskonzepte vorgestellt. Insbesondere die Sofortimplantation und -versorgung nach Extraktion eines nichterhaltungswürdigen Zahnes bietet im Vergleich zu den konventionellen Verfahren die größte Zeitersparnis und Kostenreduktion für den Patienten. Eine strenge Indikationsstellung ist maßgeblich für den Erfolg dieses Therapiekonzepts. Unter Berücksichtigung der Indikation, biologischer und anatomischer Faktoren sowie des prothetischen Versorgungs- und Belastungskonzepts bietet die Sofortimplantation nach Extraktion hinsichtlich Implantatüberleben und -erfolg vergleichbare Ergebnisse wie konventionelle Konzepte. Der vorliegende Artikel zeigt die chirurgischen und prothetischen Möglichkeiten sowie Komplikationen und Risiken auf der Grundlage des aktuellen wissenschaftlichen Kenntnisstandes zu dieser Thematik auf
Semi-quantitative assessment of environmental tobacco smoke exposure and its association with the development of oral squamous cell carcinoma: A pilot study
No full textTwo known major risk factors for oral squamous cell carcinoma are smoking and alcohol consumption. Environmental tobacco smoke (also known as secondhand smoke) has been proven to be associated with the occurrence of lung and breast carcinoma. This study aimed to assess exposure to environmental tobacco smoke and its association with the development of oral squamous cell carcinomas.Open-Access-Publikationsfonds 202
Can tongue shadow in panoramic radiographs be avoided by using the tongue repositioning maneuver?
No full textObjective. The purpose of this study was to evaluate the use of the tongue repositioning maneuver (TRM) during panoramic radiography so as to avoid the error of tongue shadow. Study Design. A total of 300 panoramic radiographs were evaluated. One hundred and fifty orthopantomograms with conventional positioning technique were used as a control group, while other 150 were taken with the patient performing the TRM. The tongue shadow was measured in each radiograph in the first molar regions bilaterally and in the midsagittal plane. Wilcoxon Mann-Whitney U-Test was used to test the significance difference between the groups. Results. The tongue-palate distance in the study group was reduced from a mean value of 6.4 mm to 1 mm in the right first molar, 8.0 mm to 2.2 mm in the midsagittal region, and 6.6 mm to 1.2 mm in the left first molar position. Statistical evaluation exhibited significant differences of tongue shadow at all measuring sites between study and control group (P < .0001). Conclusions. The present study demonstrates that the TRM leads to a substantial reduction of the tongue position error in panoramic radiography
Sialoendoscopy as a diagnostic and therapeutic option for obstructive diseases of the large salivary glands-a retrospective analysis
No full textThe diagnosis and therapy of obstructive inflammatory disorders of the salivary glands have changed in the past decades following the introduction of sialoendoscopy. The aims of the present study were to analyze the relevance of sialoendoscopy using our own data and to compare the results to those of other studies. A retrospective analysis of 70 patients was performed, who were treated for obstructive disorders of the parotid and/or submandibular gland in whom sialoendoscopy was indicated. Two categories of interventions were considered: diagnostic interventional sialoendoscopy and endoscope-assisted interventions. Interventional sialoendoscopy procedures requiring extirpation of the gland were included in the analysis, as were abnormal intraductal processes that were detected during endoscopy. Treatment was successful in 58 of 67 (86.6 %) procedures (sialoendoscopy without surgical intervention n = 59; endoscope-assisted surgical intervention n = 8). Based on the underlying disease, the success rate was 88.6 % (n = 39) in patients with obstructive sialadenitis without sialolithiasis and 86.6 % (n = 19) in patients with sialolithiasis. It was not possible to draw definitive conclusions on the underlying disease from the observed pathological intraductal changes. Sialoendoscopy is an effective and safe diagnostic and therapeutic option with low complication rate. However, limiting factors such as the size or the position of potentially removable obstacles must be taken into consideration. The rate of gland extirpations can be reduced using sialoendoscopy
Die standardisierte Untersuchung und spezielle diagnostische Verfahren in der Oralmedizin
No full textEine Veränderung der Mundhöhlenschleimhaust sollte einen Diagnoseprozess in Gang setzten, der in der täglichen Praxis möglichst gleichbleibend und standardiert abläuft. Am Ende steht meist ein Arbeit- oder bereits die definitive Diagnose, welche als Grundlage der Therapieplanung dient. Die Anamnese als erster Schritt begnügt sich im einfachsten Fall mit der Frage nach den Beschwerden, berücksichtigt aber ormalerweise auch wichtige allgemeinmedizinische Schlüsselbereich
Deep neck infections: A single-center analysis of 63 cases
Full text linkBackground and Purpose: With the use of antibiotic therapy, the incidence of deep neck infections has decreased in recent decades. The aim of this investigation was to review the clinical course and the management of deep neck infections in our department, compare them to the experiences of the common literature and identify predisposing factors for lethal complications. Material and Methods: In this single-center analysis, 63 patients with deep neck infections were treated surgically. The following clinical data were analyzed and compared: age, gender, laboratory data, spatial manifestation, therapeutic modalities, comorbidities, length of hospitalization and complications. Results: There was a predominance of male patients (58.7%) and a mean age of 57.9 years. The most common symptoms at diagnosis were sore throat (96.8%) and neck swelling (92.0%). Cardio/pulmonary diseases and diabetes mellitus were the most common comorbidities. There was a significantly longer hospital stay for patients with diabetes mellitus. The most common manifestation was a parapharyngeal abscess in 24 patients (38.1%), followed by peri-/retrotonsillar infections in 19 patients (30.2%). In 29 patients, a multiple space infection was observed, with a significantly longer duration of hospitalization and a higher rate of complications. The main life-threatening complication was the development of airway obstruction in 20 patients (31.7%), who all received a tracheostomy. The duration of hospitalization for patients with complications was significantly longer. Conclusions: Close attention must be paid to the management of patients with deep neck infections, especially patients with diabetes mellitus and cardio/pulmonary diseases or patients with multiple space infections. Key words:Deep neck infections, comorbidities, surgical treatment, tracheostomy, diabetes mellitus
Experimental variation of the level and the ratio of angiogenic and osteogenic signaling affects the spatiotemporal expression of bone-specific markers and organization of bone formation in ectopic sites
No full text(1) Objectives: The aim of the present study was to test the hypothesis that the ratio of angiogenic and osteogenic signaling affects ectopic bone formation when delivered in different amounts. (2) Materials and methods: Porous composite PDLLA/CaCO3 scaffolds were loaded with rhBMP2 and rhVEGF in different dosage combinations and implanted into the gluteal muscles of 120 adult male Wistar rats. Bone formation and expression of alkaline phosphatase and Runx2 were quantified by histomorphometry. Spatial distribution across the scaffolds was assessed by using a grid that discriminated between the periphery and center of the scaffolds. (3) Results: The evaluation showed that the combined delivery of bone morphogenetic protein BMP2 and VEGF in different dosage combinations did not enhance the overall quantity of ectopic bone formation compared to the delivery of BMP2 alone. The addition of VEGF generally upregulated Runx2 after 4 weeks, which may have retarded terminal osteogenic differentiation. However, slow combined delivery of 1.5–2.0 μg BMP2 combined with 50 ng VEGF165 over a period of 5 weeks supported a more even distribution of bone formation across the implanted scaffolds whereas higher amounts of VEGF did not elicit this effect. (4) Conclusions: The findings suggest that structural organization rather than the quantity of ectopic bone formation is affected by the dosage and the ratio of BMP2 and VEGF levels at the observed intervals. Clinical relevance The development of carriers for dual growth factor delivery has to take into account the necessity to carefully balance the ratio of growth release
The incidence of occult metastasis and the status of elective neck dissection in salivary adenoid cystic carcinoma: a single center study
No full textAlterations of bone proteins in medication‐related osteonecrosis of the jaw
No full textAbstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research. The aim of the present study was to investigate the bone proteins collagen 1, runt‐related transcription factor 2 (RUNX2), and tumor necrosis factor ligand superfamily member 11 (RANKL). Furthermore, we established a cell lineage of OLAB suitable for the analyses of protein expression. We used immunohistochemistry to determine protein expression patterns in vivo. OLAB were treated during culture with zoledronate or denosumab and analyzed by immunocytochemistry and western blotting. Collagen 1 was decreased in vivo in patients with MRONJ and in vitro by denosumab. Zoledronate reduced the level of RUNX2 in vitro. However, RANKL was not significantly affected by zoledronate or denosumab. The results of the present study will help us elucidate the cellular mechanisms of MRONJ. Although culture of OLAB with zoledronate and denosumab significantly altered the protein expression patterns, future research is needed to examine the effects of bone scaffolds, biofilms, and additional cell types mimicking in vivo conditions
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