1,721,067 research outputs found
Underlying CT data supporting the publication "A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs"
No full textUnderlying CT data supporting the article "A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs" by Paola Zgouro et al
Microfocus Computed Tomography (μCT)X-ray was employed for the characterization of the microstructure of the printed object, assessing the overall volume, porosity, local thickness and other printing defects. The imaging took place at the University of Southampton’s μ-VIS X-ray Imaging Centre (www.muvis.org) / 3D X-ray Histology facility using a customized μCT scanner optimized for 3D X-ray histology (www.xrayhistology.org) (Katsamenis et al., 2023) based on Nikon’s XTH225ST system (Nikon Metrology, Castle Donington, UK). The scanner was operated at 110 kVp / 90 μA (9.9 W), with the X-ray beam prefiltered using 0.04 mm of aluminum. The source-to-object and source-to-detector distances were 28.4 mm and 1136.7 mm, respectively, resulting in a magnification factor of 40x. Acquisition parameters included 2201 projections, averaging 4 frames per projection, with an exposure time of 177 ms per projection. The 2850 x 2850 dexels detector was binned 2x (virtual detector: 1425 × 1425 dexels), resulting in an isotropic voxel edge of 7.5 μm. The reconstructed data underwent visualization and analysis using Dragonfly software (Comet Technologies Canada Inc.; software available at http://www.theobjects.com/dragonfly).
The data is stored at https://doi.org/10.5281/zenodo.10614260</span
Behaviour and Reproduction of Drosophila Melanogaster Exposed to 3.5 GHz Radio-Frequency Electromagnetic Fields - Underlying data
No full textOverview
This dataset contains segmented STL 3D models, TIFF imaging data, and visualisations of the Drosophila (fruit fly) scan used in this study </span
The role of nanoscale toughening mechanisms in osteoporosis
No full textStrength is the most widely reported parameter with regards to bone failure. However, bone contains pre-existing damage and stress concentration sites, perhaps making measures of fracture toughness more indicative of the resistance of the tissue to withstand fracture. Several toughening mechanisms have been identified in bone, prominently, at the microscale. More recently, nanoscale toughness mechanisms, such as sacrificial-bonds and hidden-length or dilatational band formation, mediated by noncollagenous proteins, have been reported. Absence of specific noncollagenous proteins results in lowered fracture toughness in animal models. Further, roles of several other, putative influencing, factors such as closely bound water, collagen cross-linking and citrate bonds in bone mineral have also been proposed. Yet, it is still not clear if and which mechanisms are hallmarks of osteoporosis disease and how they influence fracture risk. Further insights on the workings of such influencing factors are of high importance for developing complementary diagnostics and therapeutics strategie
Interaction of fullerenes C60 with large unilamellar vesicles
No full textIn order to explore the fullerene-lipid interaction, we have studied\nthe effects caused by C-60 on Large Unilamellar Vesicles (LUV). For\nthis purpose liposomes composed of L-a Phosphatidylcholine (PC) and\n1,2-dimyristoyl-sn-glycero-3-phospocholine (DMPC) and Cholesterol\n(Chol) in 2:1 molar ratio were used. The dispersions were characterized\nby means of Dynamic Light Scattering (DLS), zeta-potential measurements\nand Differential Scanning Calorimetry studies (DSC). The incorporation\nof C-60 into liposomes altered their physicochemical properties. A\nreduction to the mean diameter of the liposomes was observed when C-60\nwere incorporated, which might imply deformations on the lipid membrane\ninduced by fullerenes. An increase to the surface charge of the\nliposomes was noticed when C-60 molecules were present in the membrane\nproviding evidence of their successful incorporation into the liposomal\nbilayers. Finally the miscibility of liposomes with C-60 was\ninvestigated by DSC. Alterations occurred to the main transition of the\nliposomes when C-60 molecules were present in the membrane might be\nattributed to the penetration of the carbonaceous material into the\nlipid bilayers
A floating 3D printed formulation for the coadministration and sustained release of antihypertensive drugs - Underlying CT data
No full textUnderlying CT data of Zgouro et al (2024) "A floating 3D printed polypill formulation for the coadministration and sustained release of antihypertensive drugs", International Journal of Pharmaceutics, 655, 124058, https://doi.org/10.1016/j.ijpharm.2024.124058
Microfocus Computed Tomography (μCT)
X-ray microfocus computed tomography (μCT) was employed for the characterization of the microstructure of the printed object, assessing the overall volume, porosity, local thickness and other printing defects. The imaging took place at the University of Southampton’s μ-VIS X-ray Imaging Centre (www.muvis.org) / 3D X-ray Histology facility using a customized μCT scanner optimized for 3D X-ray histology (www.xrayhistology.org) (Katsamenis et al., 2023) based on Nikon’s XTH225ST system (Nikon Metrology, Castle Donington, UK). The scanner was operated at 110 kVp / 90 μA (9.9 W), with the X-ray beam prefiltered using 0.04 mm of aluminum. The source-to-object and source-to-detector distances were 28.4 mm and 1136.7 mm, respectively, resulting in a magnification factor of 40x. Acquisition parameters included 2201 projections, averaging 4 frames per projection, with an exposure time of 177 ms per projection. The 2850 x 2850 dexels detector was binned 2x (virtual detector: 1425 × 1425 dexels), resulting in an isotropic voxel edge of 7.5 μm. The reconstructed data underwent visualization and analysis using Dragonfly software (Comet Technologies Canada Inc.; software available at http://www.theobjects.com/dragonfly).</span
muVIS 3D x-ray CT scan of Newport Series brown earth loamy sand sieved to <2mm with wheat plant (cultivar Skyfall)
No full textx-ray CT at 160micron resolution using Hutch scanner at muVIS centre in Southampton
You can make a request to access this data via http://library.soton.ac.uk/datarequest</span
A possible case of hypertrophic osteopathy in osteological remains representing a cattle hide from a Roman villa in England: Supporting X-ray microtomography data
No full textData Deposition: "A Possible Case of Hypertrophic Osteopathy in Osteological Remains Representing a Cattle Hide from a Roman Villa in England"</span
X-ray microfocus Computed Tomography: a powerful tool for structural and functional characterisation of 3D printed dosage forms
No full textOne of the most promising advances in modern pharmaceutical technology is the introduction of three-dimensional (3D) printing technology for the fabrication of drug products. 3D printed dosage forms have the potential to revolutionize pharmacotherapy as streamlined production of structurally complex formulations with optimal drug releasing properties is now made possible. 3D printed formulations are derived as part of a process where a "print-head" deposits, or sinters material under computer control to produce a drug carrier. However, this manufacturing route inherently generates objects that deviate from the ideal designed template for reasons specific to the 3D printing method used. This short opinion article discusses the potential of high-resolution non-destructive 3D (volume) imaging by means of X-ray microfocus Computed Tomography (μCT) as a Process Analytical Technology for the structural and functional characterisation of 3D printed dosage forms. </p
A possible case of hypertrophic osteopathy in osteological remains representing cattle hide processing from a Roman villa in England
No full textObjective: to evaluate the likelihood that pathological features noted on cattle bones indicate that the animal suffered hypertrophic osteopathy.Materials: cattle bones, mostly from the lower extremities, representing a single individual, recovered from a Romano-British villa (4th century CE).Methods: the remains were subject to macroscopic, low-power microscopic, radiographic and μCT study, as well as biomolecular analysis for M. tuberculosis complex and Brucella species DNA.Results: the remains represent a single individual and show bilaterally symmetrical subperiosteal new bone formation with no micro-anatomical alteration of the underlying bone structure. aDNA analysis was negative for M. tuberculosis and Brucella, but positive for bovine mitochondrial DNA (mtDNA).Conclusions: hypertrophic osteopathy is the most likely differential diagnoses.Significance: hypertrophic osteopathy is uncommon in bovids, and this is the first suspected case in livestock remains from an archaeological site. It demonstrates the importance of differential diagnosis in disarticulated remains through recognition of skeletal patterning.Limitations: the diagnosis is hampered by the incomplete nature of the remains.Suggestions for further research: given the primacy of chronic infection as a cause of hypertrophic osteopathy in the past, scanning these remains for evidence of pathogens using Next Generation Sequencing when feasible, and other biomolecular techniques may be useful.</p
Toughness and damage susceptibility in human cortical bone is proportional to mechanical inhomogeneity at the osteonal-level
No full textLimitations associated with current clinical fracture risk assessment tools highlight the need for increased understanding of the fracture mechanisms of the bone and, ideally, a means of assessing this in vivo. Being a multi-layered hierarchical structure, the overall properties of the bone are dictated by its structural and compositional properties over multiple length scales. In this study, we investigate the osteonal-, micro- and tissue-level mechanical behaviour of cortical bone tissue samples from young and elderly donors through atomic force microscope (AFM) cantilever-based nanoindentation, reference point microindentation (RPI) and fracture toughness experiments respectively. We demonstrate that bone's fracture toughness and crack growth resistance at the tissue-level are significantly correlated to damage susceptibility at the micro-level, and mechanical inhomogeneity between lamellae and interlamellar areas at the osteonal-level. In more detail, reduced nanoelasticity inhomogeneity of lamellar/interlamellar layers within the osteons correlated to increased indentation depth at the micro-level and an overall reduction in crack-growth toughness and fracture toughness of the tissue. Our data also suggest that deterioration of bone's mechanical properties is expressed concurrently at these three levels, and that mechanical inhomogeneity between the principal structural units of the cortical tissue holds a key role on bone's toughness behaviour. We hypothesise that the reduction in nanoelasticity inhomogeneity is – at least to some extent – responsible for the inability of the microstructure to effectively adapt to the applied load, e.g. by redistributing strains, in a non-catastrophic manner preventing damage formation and propagation. Our hypothesis is further supported by synchrotron radiation micro-computed tomography (SR?CT) data, which show that failure of tougher bone specimens is governed by increased deflection of the crack path and broadly spread damage around the crack-tip. In contrast, shorter and more direct crack paths as well as less-distributed damage were evidenced during failure of the weaker specimens. Overall, this multi-scale study highlights the importance of elasticity inhomogeneity within the osteon to the damage susceptibility and consequently to the fracture resistance of the tissue
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