216 research outputs found
The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae.
No full textThe actin cytoskeleton is essential for polarized, bud-directed movement of cellular membranes in Saccharomyces cerevisiae and thus ensures accurate inheritance of organelles during cell division. Also, mitochondrial distribution and inheritance depend on the actin cytoskeleton, though the precise molecular mechanisms are unknown. Here, we establish the class V myosin motor protein, Myo2, as an important mediator of mitochondrial motility in budding yeast. We found that mutants with abnormal expression levels of Myo2 or its associated light chain, Mlc1, exhibit aberrant mitochondrial morphology and loss of mitochondrial DNA. Specific mutations in the globular tail of Myo2 lead to aggregation of mitochondria in the mother cell. Isolated mitochondria lacking functional Myo2 are severely impaired in their capacity to bind to actin. laments in vitro. Time-resolved. uorescence microscopy revealed a block of bud-directed anterograde mitochondrial movement in cargo binding-defective myo2 mutant cells. We conclude that Myo2 plays an important and direct role for mitochondrial motility and inheritance in budding yeast
Memoiren. [Fragment] /
No full textAltmann tells the story of the Jewish community in Nikolsburg starting in 1370. He focuses specifically on the history of the Altmann family, especially Siegfried Altmann's grandparents. The second part of the manuscript deals with stories of Rabbi Mordechai Benet (1753-1829) as told to the author by his grand-aunt.See also archival collection.Altmann was born in Nikolsburg (Maehren) in 1887 and died in 1963 in New York. He was the director of the Institute for the Blind "Hohe Warte" in Vienna.see archival collection AR 1788Benet, MordechaiWalter, BrunoNikolsburg (Moravia)digitize
Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast
No full textThe MDM31 and MDM32 genes are required for normal distribution and morphology of mitochondria in the yeast Saccharomyces cerevisiae. They encode two related proteins located in distinct protein complexes in the mitochondrial inner membrane. Cells lacking Mdm31 and Mdm32 harbor giant spherical mitochondria with highly aberrant internal structure. Mitochondrial DNA (mtDNA) is instable in the mutants, mtDNA nucleoids are disorganized, and their association with Mmm1-containing complexes in the outer membrane is abolished. Mutant mitochondria are largely immotile, resulting in a mitochondrial inheritance defect. Deletion of either one of the MDM31 and MDM32 genes is synthetically lethal with deletion of either one of the MMM1, MMM2, MDM10, and MDM12 genes, which encode outer membrane proteins involved in mitochondrial morphogenesis and mtDNA inheritance. We propose that Mdm31 and Md32 cooperate with Mm1 Mm2 Mdm10, and Mdm12 in maintenance of mitochondrial morphology and mtDNA
Bland-Altmann Plot for agreement between Goldmann applanation tonometry (GAT) and Goldmann-correlated IOP (IOPg).
No full textBland-Altmann Plot for agreement between Goldmann applanation tonometry (GAT) and Goldmann-correlated IOP (IOPg).</p
Bland-Altmann Plot for agreement between Goldmann applanation tonometry (GAT) and corneal-compensated IOP (IOPcc).
No full textBland-Altmann Plot for agreement between Goldmann applanation tonometry (GAT) and corneal-compensated IOP (IOPcc).</p
Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast
No full textThe MDM31 and MDM32 genes are required for normal distribution and morphology of mitochondria in the yeast Saccharomyces cerevisiae. They encode two related proteins located in distinct protein complexes in the mitochondrial inner membrane. Cells lacking Mdm31 and Mdm32 harbor giant spherical mitochondria with highly aberrant internal structure. Mitochondrial DNA (mtDNA) is instable in the mutants, mtDNA nucleoids are disorganized, and their association with Mmm1-containing complexes in the outer membrane is abolished. Mutant mitochondria are largely immotile, resulting in a mitochondrial inheritance defect. Deletion of either one of the MDM31 and MDM32 genes is synthetically lethal with deletion of either one of the MMM1, MMM2, MDM10, and MDM12 genes, which encode outer membrane proteins involved in mitochondrial morphogenesis and mtDNA inheritance. We propose that Mdm31 and Md32 cooperate with Mm1 Mm2 Mdm10, and Mdm12 in maintenance of mitochondrial morphology and mtDNA
Bland-Altmann Plot for agreement between Goldmann applanation tonometry (GAT) and palpatory assessed IOP (palp IOP).
No full textBland-Altmann Plot for agreement between Goldmann applanation tonometry (GAT) and palpatory assessed IOP (palp IOP).</p
Fashion Culture: Fashion Metropolis Berlin
No full textBerlin was a fashion capital in the 1920s, with hundreds of thriving clothing manufacturers, most of them Jewish, before it was decimated by the Nazis. Author Uwe Westphal shares this history in a discussion with FIT historian Keren Ben-Horin and journalist Jennifer Altmann, whose grandfather ran one of Berlin’s fashion houses.Organized in partnership with the Museum at Eldridge Street
Economics in Persian-period biblical texts : their interactions with economic developments in the Persian period and earlier biblical traditions
No full textLarge-scale economic change such as the rise of coinage occurred during the Persian-dominated centuries (6th –4th centuries BCE) in the Eastern Mediterranean and ancient Near East. How do the biblical texts of the time respond to such developments?
In this study, Peter Altmann lays out foundational economic conceptions from the ancient Near East and earlier biblical traditions in order to show how Persian-period biblical texts build on these traditions to address the challenges of their day. Economic issues are central to the way that Ezra and Nehemiah approach the topics of temple building and of Judean self-understanding. Economic terminology and considerations also appear in Second Isaiah and the “Holiness Code.” Following significant interaction with the material culture and extra-biblical texts, the author devotes special attention to the ascendancy of economics and its theological and identity implications as structuring metaphors for divine action and human community in the Persian period.
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