434 research outputs found
Correction: Pulse dipolar EPR for determining nanomolar binding affinities
No full textCorrection for ‘Pulse dipolar EPR for determining nanomolar binding affinities’ by Katrin Ackermann et al., Chem. Commun., 2022, DOI: https://doi.org/10.1039/d2cc02360a
The amoebic growth of project costs
No full textIn the public arena, we often hear about projects that have suffered massive cost overruns. Often they are related to large public construction projects such as airports, bridges, or public buildings. Large overruns also exist in private industry. However, often these do not appear in the newspapers, so the public is not as aware of them. Of course, not all projects go badly wrong, but quite a few do, and frequently we find ourselves uncertain of the causes for such overruns. In this paper, industrial projects that overrun and overrun in a surprising manner are considered. In other words, the paper considers those many projects where the extent of the overrun is well beyond what might ever have been anticipated, even though what was going wrong within the projects was, for the most part, understood.The basis for the content of the paper (that is, the structure and lessons), are drawn from a postmortem analysis of many large projects as part of claims analysis, particularly "delay and disruption" claims for projects whose total expenditure appeared, at first look, inexplicable or surprising. The aim of the paper is to contribute to an understanding of how projects go badly wrong, when they do, and in particular to draw some lessons from this exploration that are likely to help all managers. The reasons for cost escalation are not just the responsibility of project managers.<br/
Disability Mainstreaming in Berlin - Das Thema Behinderung geht alle an
No full textDISABILITY MAINSTREAMING IN BERLIN - DAS THEMA BEHINDERUNG GEHT ALLE AN
Disability Mainstreaming in Berlin - Das Thema Behinderung geht alle an / Grüber, Katrin (Rights reserved) (-
Zwei Fallstudien zu begleitetem Wissenstransfer im Outsourcing: Implikationen für die Praxis
No full textDieses Kapitel berichtet von einem erfolgreichen und einem gescheiterten Wissenstransfer. In beiden Fällen sollte ein Softwareingenieur in einen neuen, komplexen Tätigkeitsbereich eingearbeitet werden. Die Fälle geben Einblicke darin, wie die Wissensempfänger Handlungsfähigkeit erworben haben, welche Herausforderungen dabei auftraten und wie die Begleitung des Wissenstransfers half, mit diesen Herausforderungen umzugehen. Die Fälle zeigen, 1) dass die angeleitete Arbeit an realen Aufgaben für Wissenstransfer essenziell ist, 2) dass Teams dabei mit kognitiver Überlastung der Wissensempfänger, mit anfänglich schwachen sozialen Beziehungen und mit ungünstigen Lernvorstellungen kämpfen und 3) wie begleiteter Wissenstransfer helfen kann, mit jeder dieser Herausforderungen umzugehen. Das Kapitel schließt mit einer Reihe von praktischen Empfehlungen für Wissenstransfer in komplexen Tätigkeitsbereichen
Prof. Ackermann, vision-based navigation and the PG master’s degree programme at HfT Stuttgart
No full textThe two topics of the article seem to have absolutely nothing to do with each other and, as can be expected in a contribution in honor and memory of Prof. Fritz Ackermann, they are linked in his person. Vision-based Navigation was the focus of the doctoral thesis written by the author, the 29th and last PhD thesis supervised by Prof. Ackermann. The International Master’s Program Photogrammetry and Geoinformatics, which the author established with colleagues at Stuttgart University of Applied Sciences (HfT Stuttgart) in 1999, was a consequence of Prof. Ackermann’s benevolent promotion of international knowledge transfer in teaching. Both topics are reflected in this article; they provide further splashes of color in Prof. Ackermann’s oeuvre
Prof. Ackermann, vision-based navigation and the PG master’s degree programme at HfT Stuttgart
No full textABSTRACTThe two topics of the article seem to have absolutely nothing to do with each other and, as can be expected in a contribution in honor and memory of Prof. Fritz Ackermann, they are linked in his person. Vision-based Navigation was the focus of the doctoral thesis written by the author, the 29th and last PhD thesis supervised by Prof. Ackermann. The International Master’s Program Photogrammetry and Geoinformatics, which the author established with colleagues at Stuttgart University of Applied Sciences (HfT Stuttgart) in 1999, was a consequence of Prof. Ackermann’s benevolent promotion of international knowledge transfer in teaching. Both topics are reflected in this article; they provide further splashes of color in Prof. Ackermann’s oeuvre
Analysis of influenza A virus NS1 dimer interfaces in solution by pulse EPR distance measurements
No full textH.L.T. was supported by the University of St Andrews; S.A.J. is supported by the BBSRC, U.K.; P.S.K. is supported by the Medical Research Council, U.K.; B.E.B. is grateful for an EaStCHEM Hirst Academic Fellowship by the School of Chemistry, St Andrews, and funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme [REA 334496]. This work was supported by the Wellcome Trust [099149/Z/12/Z].Pulsed electron-electron double resonance (PELDOR) is an electron paramagnetic resonance (EPR) spectroscopy technique for nanometer distance measurements between paramagnetic centres such as radicals. PELDOR has been recognized as a valuable tool to approach structural questions in biological systems. In this manuscript we demonstrate the value of distance measurements for differentiating competing structural models on the dimerization of the effector domain (ED) of the non-structural protein 1 (NS1) of the influenza A virus. Our results show NS1 to be well amenable to nanometer distance measurements by EPR, yielding high quality data. In combination with mutants perturbing protein dimerization and in silico prediction based on crystal structures we can exclude one of two potential dimerization interfaces. Furthermore, our results lead to a viable hypothesis of a NS1 ED:ED interface which is flexible through rotation around the vector interconnecting the two native cysteines. These results prove the high value of pulse EPR as a complementary method for structural biology.Peer reviewe
Jetzt erschienen: Tagungsbericht zum Studientag "Diplomatie unter Druck?"
No full textFranzösische Botschaft in Berlin Ein Tagungsbericht zum Studientag „Diplomatie unter Druck? Legitimität als diplomatisches Problem im 19. Jahrhundert“, der am 28. Februar 2014 im DHIP stattfand, ist jetzt erschienen. Die Verfasserin ist Nadja Ackermann (Universität Bern). Der Bericht ist auf H-Soz-u-Kult veröffentlicht worden: http://hsozkult.geschichte.hu-berlin.de/tagungsberichte/id=5352&count=5143&recno=3&sort=datum&order=down Das Programm des Studientags - mit Verweisen auf die Abstracts ..
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