1,776 research outputs found
‘Doe niet alsof burgemeesters demonstraties ‘toestaan’, dat is Wilders’ frame - de wet staat ze toe’
No full textZeggen dat burgemeesters demonstraties ‘toestaan’ is onjuist, schrijft Niels Karsten, want dat zijn demonstraties in beginsel al. Deze formulering duwt burgervaders en -moeders volgens hem in een frame, waarin ze tot politieke vijanden worden gebombardeerd
‘Doe niet alsof burgemeesters demonstraties ‘toestaan’, dat is Wilders’ frame - de wet staat ze toe’
No full textZeggen dat burgemeesters demonstraties ‘toestaan’ is onjuist, schrijft Niels Karsten, want dat zijn demonstraties in beginsel al. Deze formulering duwt burgervaders en -moeders volgens hem in een frame, waarin ze tot politieke vijanden worden gebombardeerd
Boven de partijen: Over de kwetsbare positie van burgemeesters
Get PDFDe belangrijkste bron van gezag voor burgemeesters is hun positie ‘boven de partijen’. Maar wat betekent die positie nu eigenlijk? We voelen eenvoudig aan wat daarmee bedoeld wordt, omdat die rol al decennialang kenmerkend is voor het burgemeestersambt en ze goed aansluit bij de Nederlandse interpretatie van het begrip leiderschap. In dit artikel verkennen Niels Karsten en Laurens de Graaf het ‘boven de partijen staan’ nader en reflecteren ze aan de hand daarvan op enkele ontwikkelingen en kwetsbaarheden in het burgemeestersambt
Simulating psoriasis by altering transit amplifying cells
No full textComputational models of tissue homeostasis will facilitate a deeper understanding of many diseases. They link molecular networks, cellular differentiation and the spatial and temporal organization of tissues. Here we show an approach which is able to computationally turn a healthy in silico epidermis into one with four central properties of psoriatic epidermis. We achieve this by altering a single simulation parameter in the cellular differentiation program of the simulated epidermal keratinocytes: the fractional time period during which transit amplifying cells proliferate (tau). Prolonging tau results in the four main pathological characteristics of psoriatic skin: (1) an absolute increase of the germinative compartment, (2) an absolute increase of the differentiated compartment, (3) a higher proportion of germinative cells and (4) a marked reduction in turnover time. The prolongation of tau is able to increase the proliferation capacity of the epidermal tissue without altering the cell cycle frequency
Doe niet alsof burgers de nieuwe burgemeester van Tilburg kunnen kiezen
No full textSinds kort mogen Tilburgers meedenken over de opvolging van burgemeester Theo Weterings. In een enquête kunnen inwoners aangeven welke eigenschappen de nieuwe burgemeester moet hebben. De manier waarop deze enquête wordt gepresenteerd, kan er echter toe leiden dat inwoners zich juist voor de gek gehouden voelen, schrijven Frank Hendriks en Niels Karsten
Doe niet alsof burgers de nieuwe burgemeester van Tilburg kunnen kiezen
No full textSinds kort mogen Tilburgers meedenken over de opvolging van burgemeester Theo Weterings. In een enquête kunnen inwoners aangeven welke eigenschappen de nieuwe burgemeester moet hebben. De manier waarop deze enquête wordt gepresenteerd, kan er echter toe leiden dat inwoners zich juist voor de gek gehouden voelen, schrijven Frank Hendriks en Niels Karsten
ZAK Talks: Öffentliches Symposium - Diskussionsrunde (Wendland, Pinkwart, Meyer, Post)
No full textKI in der Schule, Arbeit und Medien? Welche Zukunft hat Künstliche Intelligenz in unserem Alltag? Es geht um hohe Erwartungen und Möglichkeiten, aber auch um Risiken und Ängste. Im öffentlichen Symposium der ZAK Talks diskutieren Expertinnen die KI-Entwicklungen in unterschiedlichen Bereichen und sprechen über die Rolle der KI in unserer Gesellschaft.
Es diskutierten:
Prof. Dr. Karsten Wendland (Professor für Medieninformatik, Hochschule Aalen / Senior Researcher,
Institut für Technikfolgenabschätzung und Systemanalyse (ITAS), KIT)
Prof. Dr. Niels Pinkwart (Professor für Didaktik der Informatik / Informatik und Gesellschaft,
Humboldt-Universität zu Berlin / Wiss. Direktor des Educational Technology Lab, DFKI)
Prof. Dr. Bertolt Meyer (Professor für Arbeits-, Organisations- und Wirtschaftspsychologie,
Institut für Psychologie, Technische Universität Chemnitz)
Moderation: Prof. Dr. Senja Post (Wissenschaftliche Leiterin des ZAK)
Die Diskussion fand statt während der „ZAK Talks“ am Abschlusswochenende der KIT Science Week 2021 am 9. Oktober 2021
A multicellular systems biology model predicts epidermal morphology, kinetics and Ca2+ flow
No full textSystems biology is currently focused on integrating intracellular networks, although clinically, diseases are largely defined by their histological features. For example, no computational model can simulate today the formation of a horizontally layered epidermis. Since the epidermis is the most complex structured epithelial tissue, systems biology models could yield important insights in epithelial tissue, in which most of all human cancers arise
Families versus Machines: On how a startup can improve digital well-being in the family life
No full textThe goal of this project was to find a way to improve digital well-being in family life through design for the startup Unpluq. In this thesis, the designer combined a design approach called Value Sensitive Design with the list of requirements methodology taught at Industrial Design Engineering. This resulted in a new methodology that allowed the designer to develop a concrete list of requirements and wishes for improving well-being through design. To establish this list of requirements, the design student performed a detailed literature review on positive psychology, behavioural economics and digital parenting literature. In addition to this, he interviewed both parents and children to empathise with their world views. Lastly, he performed a market analysis to understand how the context and available resources could affect Unpluq’s capacity to take up a role in this new market. Based on this research, the answer found is that improving digital well-being in the family life requires the design of a choice architecture that helps parents and children take more conscious control of their time and attention (both transactional values). Doing so should allow them to spend these transactional values on activities that align with things they intrinsically value. This choice architecture should help rearrange actors, artefacts, and stimuli within the family home environment so that time is less easily spent without intentional consent. Based on this list of requirements, the design student initiated a design process to translate these insights into a physical design concept that Unpluq could bring to the market to help families rearrange this choice architecture. This design process was executed by iteratively evaluating design concepts with both the client, potential end-users, experts, and professionals from different psychology and pedagogics fields. In the end, the designer delivered a concept that stimulates reflective thinking about what users find intrinsically valuable and provides tips, tools and challenges that push them to try and change habits. This is done by focusing on conversations that help raise awareness of the critical issues and stimulating the iterative goal setting that the family should engage in to start solving these issues for themselves. The way that time can and should be allocated for intrinsically valued activities was so unique for each individual and family that it is hard to find one solution to help everyone. Therefore, the core insight of this project for Unpluq is that if they would be interested in entering this market, their focus should be on helping families reimagine the way they use their environments within their own family homes. This should be done both individually and together through reflection and iteration and supported in that journey by scientific and expert information.https://unpluq.com/graduation-niels/ Presentation webpageStrategic Product Desig
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